Bile secretion Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates. (Kyoto Encyclopedia of Genes and Genomes, hsa04976)
External Link https://www.kegg.jp/entry/hsa04976
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Genes

88 proteins participating in the Bile secretion pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
AQP4 aquaporin 4
AQP8 aquaporin 8
AQP9 aquaporin 9
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide
BAAT bile acid CoA:amino acid N-acyltransferase
CA2 carbonic anhydrase II
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FXYD2 FXYD domain containing ion transport regulator 2
GNAS GNAS complex locus
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LDLR low density lipoprotein receptor
MINDY4 MINDY lysine 48 deubiquitinase 4
NCEH1 neutral cholesterol ester hydrolase 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
RXRA retinoid X receptor, alpha
SCARB1 scavenger receptor class B, member 1
SCT secretin
SCTR secretin receptor
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SLC51A solute carrier family 51, alpha subunit
SLC51B solute carrier family 51, beta subunit
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UGT2A2 UDP glucuronosyltransferase 2 family, polypeptide A2
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7