| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bimatoprost perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bimatoprost_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.14413 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.139121 |
| HMGA2 | high mobility group AT-hook 2 | 0.110975 |
| YAP1 | Yes-associated protein 1 | 0.107757 |
| RRM2 | ribonucleotide reductase M2 | 0.0987281 |
| INTS6 | integrator complex subunit 6 | 0.0821752 |
| PTMA | prothymosin, alpha | 0.0783751 |
| WWOX | WW domain containing oxidoreductase | 0.0657767 |
| CANX | calnexin | 0.0576073 |
| ASPH | aspartate beta-hydroxylase | 0.0569395 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0532825 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0529413 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0519358 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0516929 |
| PCDH9 | protocadherin 9 | 0.0506804 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0489496 |
| RPS12 | ribosomal protein S12 | 0.0485532 |
| ENO1 | enolase 1, (alpha) | 0.0460737 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0453143 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.043983 |
| YBX3 | Y box binding protein 3 | 0.0437053 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0428304 |
| ZNF638 | zinc finger protein 638 | 0.0393908 |
| PRELID2 | PRELI domain containing 2 | 0.0393134 |
| IPO7 | importin 7 | 0.0392318 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.038617 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0385183 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0372265 |
| DENND5A | DENN/MADD domain containing 5A | 0.0362447 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0345009 |
| NHSL1 | NHS-like 1 | 0.0344934 |
| ADIPOR2 | adiponectin receptor 2 | 0.0342554 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0339148 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0337118 |
| CALR | calreticulin | 0.0335592 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0333119 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0327656 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0317548 |
| TPM3 | tropomyosin 3 | 0.0305037 |
| LRRC23 | leucine rich repeat containing 23 | 0.0303287 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0303 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0301131 |
| R3HDM2 | R3H domain containing 2 | 0.0299441 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0297925 |
| RPL37A | ribosomal protein L37a | 0.0294534 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0293979 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0293732 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0290756 |
| NEBL | nebulette | 0.0289023 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.02863 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0284288 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0279551 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0277014 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.027402 |
| SFPQ | splicing factor proline/glutamine-rich | 0.027393 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0271553 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0270642 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.027021 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.02663 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0261568 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0261391 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0260172 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.025713 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0254828 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.02547 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0254043 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0250973 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0248613 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.024823 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0247447 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0247237 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0247134 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0244917 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0244046 |
| SERTAD2 | SERTA domain containing 2 | 0.0242947 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0240604 |
| NDRG1 | N-myc downstream regulated 1 | 0.0240527 |
| PRKCE | protein kinase C, epsilon | 0.02395 |
| FADS2 | fatty acid desaturase 2 | 0.0238652 |
| ETV6 | ets variant 6 | 0.0238639 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0238286 |
| JMJD1C | jumonji domain containing 1C | 0.0237302 |
| RTN4 | reticulon 4 | 0.0235819 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0235408 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0232265 |
| DSPP | dentin sialophosphoprotein | 0.0232136 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0230263 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0229161 |
| EPHA6 | EPH receptor A6 | 0.0228394 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0228061 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0226415 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0225772 |
| RPL9 | ribosomal protein L9 | 0.0222905 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0222886 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0221248 |
| ALMS1 | Alstrom syndrome protein 1 | 0.0216264 |
| MSN | moesin | 0.0213825 |
| MT2A | metallothionein 2A | 0.0213797 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0212071 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0211964 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.233441 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.100823 |
| AREG | amphiregulin | -0.0987748 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0842618 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.072268 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0712731 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.067935 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0637469 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0634872 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0625045 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0571008 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0570264 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0555222 |
| BCHE | butyrylcholinesterase | -0.0554321 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0544134 |
| CLDN1 | claudin 1 | -0.0543821 |
| KIF5B | kinesin family member 5B | -0.0503197 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0488882 |
| MKI67 | marker of proliferation Ki-67 | -0.0488329 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0466387 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.046204 |
| ZNF804A | zinc finger protein 804A | -0.0457736 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0453511 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0436913 |
| SBF2 | SET binding factor 2 | -0.0434691 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0428119 |
| RASAL2 | RAS protein activator like 2 | -0.0427473 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0426537 |
| KPNB1 | karyopherin (importin) beta 1 | -0.042034 |
| CARD16 | caspase recruitment domain family, member 16 | -0.041965 |
| NF1 | neurofibromin 1 | -0.0417771 |
| EGR1 | early growth response 1 | -0.0412266 |
| TMEM123 | transmembrane protein 123 | -0.041127 |
| AHNAK | AHNAK nucleoprotein | -0.0406192 |
| NLGN1 | neuroligin 1 | -0.0391823 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0388547 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0388377 |
| YBX1 | Y box binding protein 1 | -0.037671 |
| EDARADD | EDAR-associated death domain | -0.0369807 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0364063 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0362387 |
| MGAT4C | MGAT4 family, member C | -0.03546 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0351385 |
| TSPAN5 | tetraspanin 5 | -0.0348655 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0347539 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0344222 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0343472 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0339336 |
| PRR16 | proline rich 16 | -0.0335767 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0332174 |
| TUBB | tubulin, beta class I | -0.0330402 |
| CENPE | centromere protein E, 312kDa | -0.0325373 |
| TMEM131 | transmembrane protein 131 | -0.0321998 |
| MAP1B | microtubule-associated protein 1B | -0.031915 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0316823 |
| SYT1 | synaptotagmin I | -0.0313243 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0312524 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0305588 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0301297 |
| CCND1 | cyclin D1 | -0.0294711 |
| HMGA1 | high mobility group AT-hook 1 | -0.0292353 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0291295 |
| EDN1 | endothelin 1 | -0.028974 |
| MMP12 | matrix metallopeptidase 12 | -0.028831 |
| WDR45B | WD repeat domain 45B | -0.0286073 |
| WDR43 | WD repeat domain 43 | -0.028345 |
| TENM3 | teneurin transmembrane protein 3 | -0.028304 |
| PCDH7 | protocadherin 7 | -0.027952 |
| ECT2 | epithelial cell transforming 2 | -0.0277559 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0273971 |
| CENPF | centromere protein F, 350/400kDa | -0.0270334 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.026782 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0262273 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0261564 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0261195 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0259452 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0258744 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0253056 |
| CDK17 | cyclin-dependent kinase 17 | -0.0250925 |
| RPL4 | ribosomal protein L4 | -0.0247345 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0247089 |
| KLHL24 | kelch-like family member 24 | -0.0245335 |
| KIF18B | kinesin family member 18B | -0.0244588 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0240918 |
| YEATS2 | YEATS domain containing 2 | -0.0240261 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0238802 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.023721 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0234926 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | -0.0234334 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0233925 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0230597 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0228755 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0227589 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0227308 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0225822 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0224064 |
| MATR3 | matrin 3 | -0.0222749 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0222365 |
| NABP1 | nucleic acid binding protein 1 | -0.0220965 |
| TGM2 | transglutaminase 2 | -0.022018 |
