Bimatoprost_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimatoprost perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimatoprost_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.163421
EXT1 exostosin glycosyltransferase 1 0.11155
VCL vinculin 0.109517
AKAP12 A kinase (PRKA) anchor protein 12 0.106401
FNDC3B fibronectin type III domain containing 3B 0.0930708
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0729506
PTPRD protein tyrosine phosphatase, receptor type, D 0.0721481
LSAMP limbic system-associated membrane protein 0.0703749
DST dystonin 0.0703424
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0664114
PLAT plasminogen activator, tissue 0.0663799
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0638075
TLE4 transducin-like enhancer of split 4 0.0607367
CEMIP cell migration inducing protein, hyaluronan binding 0.0579255
TPST1 tyrosylprotein sulfotransferase 1 0.0560749
ZSWIM6 zinc finger, SWIM-type containing 6 0.0546087
PLPP1 phospholipid phosphatase 1 0.0534094
TRIO trio Rho guanine nucleotide exchange factor 0.0527949
PSD3 pleckstrin and Sec7 domain containing 3 0.0514495
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0503257
ANTXR1 anthrax toxin receptor 1 0.0463607
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0442109
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0419243
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0404603
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0398552
GLCCI1 glucocorticoid induced 1 0.0391711
VMP1 vacuole membrane protein 1 0.0390929
FAM13A family with sequence similarity 13, member A 0.0372996
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0371841
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.036599
PCBP3 poly(rC) binding protein 3 0.0365529
PTPRK protein tyrosine phosphatase, receptor type, K 0.0364501
AHR aryl hydrocarbon receptor 0.0352553
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0349481
SMYD3 SET and MYND domain containing 3 0.0345108
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0343779
TENM4 teneurin transmembrane protein 4 0.0338463
SLIT2 slit homolog 2 (Drosophila) 0.0331483
KLHL13 kelch-like family member 13 0.0328085
MYH9 myosin, heavy chain 9, non-muscle 0.0322461
PRKCA protein kinase C, alpha 0.0318656
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0317031
SOS1 son of sevenless homolog 1 (Drosophila) 0.0316243
PACS1 phosphofurin acidic cluster sorting protein 1 0.0307403
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0303531
ITPRID2 ITPR interacting domain containing 2 0.0302847
COL4A2 collagen, type IV, alpha 2 0.0302494
FERMT2 fermitin family member 2 0.0301309
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0295583
ADGRB3 adhesion G protein-coupled receptor B3 0.0293435
ARHGAP9 Rho GTPase activating protein 9 0.0288964
TCF12 transcription factor 12 0.0288737
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.028445
NRIP1 nuclear receptor interacting protein 1 0.028316
MYO6 myosin VI 0.0275168
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0271605
PTPRE protein tyrosine phosphatase, receptor type, E 0.026936
FAM107B family with sequence similarity 107, member B 0.0268884
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0267702
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0267627
GPBP1 GC-rich promoter binding protein 1 0.0265433
GREM2 gremlin 2, DAN family BMP antagonist 0.0264152
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0261719
SIK2 salt-inducible kinase 2 0.0261055
LPP LIM domain containing preferred translocation partner in lipoma 0.025205
ELL2 elongation factor, RNA polymerase II, 2 0.0251686
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0251036
THSD4 thrombospondin, type I, domain containing 4 0.0250342
EHBP1 EH domain binding protein 1 0.0249848
AMOTL1 angiomotin like 1 0.0248302
NPAS2 neuronal PAS domain protein 2 0.0247695
BCAS3 breast carcinoma amplified sequence 3 0.0246965
FNDC3A fibronectin type III domain containing 3A 0.0246089
TPM1 tropomyosin 1 (alpha) 0.0245286
DNMBP dynamin binding protein 0.0243777
MSI2 musashi RNA-binding protein 2 0.0243494
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0239748
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0238448
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0234913
ADGRL2 adhesion G protein-coupled receptor L2 0.0234714
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0231709
SYNPO2 synaptopodin 2 0.0231077
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0229292
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0224065
NBEA neurobeachin 0.0223627
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0222439
MAPK8 mitogen-activated protein kinase 8 0.0221662
CNTN4 contactin 4 0.0220031
TPR translocated promoter region, nuclear basket protein 0.0219125
ITGA1 integrin, alpha 1 0.0216721
CCNY cyclin Y 0.021624
COL4A5 collagen, type IV, alpha 5 0.021546
CSNK1A1 casein kinase 1, alpha 1 0.0214659
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.021382
NAMPT nicotinamide phosphoribosyltransferase 0.0213495
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0212285
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0210685
IGF1R insulin-like growth factor 1 receptor 0.0206554
CHD9 chromodomain helicase DNA binding protein 9 0.0205028
TAS2R14 taste receptor, type 2, member 14 0.0204032

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.384848
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.166184
IGF2 insulin-like growth factor 2 -0.141917
VIM vimentin -0.0841642
RPS6 ribosomal protein S6 -0.0701586
RPLP1 ribosomal protein, large, P1 -0.0655065
RPL23 ribosomal protein L23 -0.0643776
RPL35A ribosomal protein L35a -0.0630244
RPL19 ribosomal protein L19 -0.0556686
ACTG1 actin gamma 1 -0.0436637
TMSB10 thymosin beta 10 -0.0420633
PTMA prothymosin, alpha -0.0419361
RPS19 ribosomal protein S19 -0.0389345
PKM pyruvate kinase, muscle -0.0386526
RPL34 ribosomal protein L34 -0.0372218
MAP1B microtubule-associated protein 1B -0.0368776
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0362333
FTL ferritin, light polypeptide -0.0353449
COL1A1 collagen, type I, alpha 1 -0.033946
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0331527
LPIN1 lipin 1 -0.0326637
TRIB2 tribbles pseudokinase 2 -0.0325544
RPS14 ribosomal protein S14 -0.0321713
RPS24 ribosomal protein S24 -0.0321607
POTEF POTE ankyrin domain family, member F -0.0320528
DPH6 diphthamine biosynthesis 6 -0.0309418
RPS23 ribosomal protein S23 -0.0305439
RPL38 ribosomal protein L38 -0.0298801
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0294887
DLC1 DLC1 Rho GTPase activating protein -0.029455
TPT1 tumor protein, translationally-controlled 1 -0.0292883
S100A9 S100 calcium binding protein A9 -0.0287381
RPS25 ribosomal protein S25 -0.0281186
S100A6 S100 calcium binding protein A6 -0.0280038
RPS11 ribosomal protein S11 -0.0278968
GATA3 GATA binding protein 3 -0.0260753
RPS27 ribosomal protein S27 -0.0260045
RPL28 ribosomal protein L28 -0.0257718
RPL37A ribosomal protein L37a -0.0256265
RPL12 ribosomal protein L12 -0.0247142
RPLP2 ribosomal protein, large, P2 -0.024518
RPS16 ribosomal protein S16 -0.0244028
RPS8 ribosomal protein S8 -0.0243647
EIF1 eukaryotic translation initiation factor 1 -0.0239443
RPL36 ribosomal protein L36 -0.0238051
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0236982
RPS13 ribosomal protein S13 -0.0232578
RPL32 ribosomal protein L32 -0.0228303
RPS29 ribosomal protein S29 -0.0227088
RPLP0 ribosomal protein, large, P0 -0.0222653
RPL9 ribosomal protein L9 -0.0216438
GNAS GNAS complex locus -0.0215422
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0213666
RPL31 ribosomal protein L31 -0.0209861
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0209656
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0209246
RPS5 ribosomal protein S5 -0.0207068
RPL11 ribosomal protein L11 -0.0206949
CBX3 chromobox homolog 3 -0.0204888
LMNA lamin A/C -0.0204885
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0199467
RPL30 ribosomal protein L30 -0.0195716
RPL8 ribosomal protein L8 -0.019279
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0192342
RPS21 ribosomal protein S21 -0.019054
RPL18 ribosomal protein L18 -0.0189628
EIF5B eukaryotic translation initiation factor 5B -0.0189519
ATP5F1B ATP synthase F1 subunit beta -0.0186073
HMGA1 high mobility group AT-hook 1 -0.0186
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0185351
KPNB1 karyopherin (importin) beta 1 -0.0185064
RPS15 ribosomal protein S15 -0.0182025
COL6A1 collagen, type VI, alpha 1 -0.0178303
RACK1 receptor for activated C kinase 1 -0.0177102
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0176034
WSB1 WD repeat and SOCS box containing 1 -0.017555
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.017298
MTDH metadherin -0.0172645
RPS10 ribosomal protein S10 -0.0169251
WDR45B WD repeat domain 45B -0.0168173
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0167731
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0167387
ADNP activity-dependent neuroprotector homeobox -0.0166096
ZFP36L1 ZFP36 ring finger protein-like 1 -0.01654
SERF2 small EDRK-rich factor 2 -0.0165265
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0164678
MDK midkine (neurite growth-promoting factor 2) -0.01646
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.016441
CENPE centromere protein E, 312kDa -0.016353
GOLGA4 golgin A4 -0.0161927
CLASP2 cytoplasmic linker associated protein 2 -0.0161796
RPL26 ribosomal protein L26 -0.016105
B2M beta-2-microglobulin -0.0157515
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0157381
GLG1 golgi glycoprotein 1 -0.0156303
NIPSNAP2 nipsnap homolog 2 -0.0154947
SCLT1 sodium channel and clathrin linker 1 -0.0154715
RTN4 reticulon 4 -0.0152208
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0150932
NAP1L1 nucleosome assembly protein 1-like 1 -0.0150582