| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bimatoprost perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bimatoprost_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.161392 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.1192 |
| LMO7 | LIM domain 7 | 0.0897798 |
| GRAMD1B | GRAM domain containing 1B | 0.0706378 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0705627 |
| SLTM | SAFB-like, transcription modulator | 0.0690004 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0675239 |
| INTS6 | integrator complex subunit 6 | 0.0651512 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0638291 |
| MCL1 | myeloid cell leukemia 1 | 0.0627521 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0590952 |
| SMYD3 | SET and MYND domain containing 3 | 0.0589505 |
| SCEL | sciellin | 0.0560426 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0516852 |
| MT2A | metallothionein 2A | 0.051087 |
| MYOF | myoferlin | 0.048019 |
| IRS2 | insulin receptor substrate 2 | 0.0476618 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0476077 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0457238 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0451435 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0451104 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0445806 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.044521 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0438212 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0416845 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0391189 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0385225 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0375486 |
| VCL | vinculin | 0.0373767 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0365685 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.0356763 |
| S100P | S100 calcium binding protein P | 0.0356464 |
| FNDC3A | fibronectin type III domain containing 3A | 0.035312 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0351784 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0349586 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0342852 |
| PTK2 | protein tyrosine kinase 2 | 0.0340587 |
| TOP1 | topoisomerase (DNA) I | 0.0339562 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0336971 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0327239 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0327058 |
| ANXA1 | annexin A1 | 0.0326424 |
| TES | testin LIM domain protein | 0.032504 |
| ATF6 | activating transcription factor 6 | 0.0322574 |
| SUMF1 | sulfatase modifying factor 1 | 0.0319504 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0317947 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0316709 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0315658 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0308959 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0308497 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.030616 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0305281 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0299376 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0298227 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0294148 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.029323 |
| HOMER1 | homer scaffolding protein 1 | 0.0291726 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0291436 |
| RAD51B | RAD51 paralog B | 0.0290767 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0289946 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0287427 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0284609 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0282069 |
| ZNF638 | zinc finger protein 638 | 0.027773 |
| CMIP | c-Maf inducing protein | 0.0277626 |
| EFNA5 | ephrin-A5 | 0.0277483 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0273385 |
| NABP1 | nucleic acid binding protein 1 | 0.0271273 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.027116 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0265367 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0263458 |
| GPHN | gephyrin | 0.0262299 |
| ATP11A | ATPase, class VI, type 11A | 0.0261622 |
| JMJD1C | jumonji domain containing 1C | 0.0256167 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0254114 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0252331 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0251166 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0249694 |
| HMGA2 | high mobility group AT-hook 2 | 0.0249134 |
| DST | dystonin | 0.0241469 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0240616 |
| DNER | delta/notch-like EGF repeat containing | 0.023376 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0229688 |
| PUM2 | pumilio RNA-binding family member 2 | 0.02257 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0224997 |
| DSPP | dentin sialophosphoprotein | 0.0224272 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0224089 |
| CTBP2 | C-terminal binding protein 2 | 0.022236 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0221082 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0220466 |
| MSN | moesin | 0.0219411 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0218891 |
| FOXP1 | forkhead box P1 | 0.0218274 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0217128 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0217011 |
| VMP1 | vacuole membrane protein 1 | 0.0216502 |
| WWOX | WW domain containing oxidoreductase | 0.0216477 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0212188 |
| FAT1 | FAT atypical cadherin 1 | 0.0211396 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0210911 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.293194 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.241083 |
| TXNRD1 | thioredoxin reductase 1 | -0.14063 |
| TMSB10 | thymosin beta 10 | -0.101869 |
| PKM | pyruvate kinase, muscle | -0.083873 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0838039 |
| ASPH | aspartate beta-hydroxylase | -0.064863 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0542204 |
| NDRG1 | N-myc downstream regulated 1 | -0.0527555 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0470383 |
| CES1 | carboxylesterase 1 | -0.0449313 |
| HDLBP | high density lipoprotein binding protein | -0.0442225 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.041097 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0409248 |
| ACTG1 | actin gamma 1 | -0.0402774 |
| KRT18 | keratin 18, type I | -0.0397158 |
| FTL | ferritin, light polypeptide | -0.0385887 |
| H1-0 | H1.0 linker histone | -0.0384306 |
| S100A10 | S100 calcium binding protein A10 | -0.0380725 |
| TMEM165 | transmembrane protein 165 | -0.0376217 |
| LAMC2 | laminin, gamma 2 | -0.0364938 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0362416 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0360966 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0347484 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0338678 |
| EGR1 | early growth response 1 | -0.0313322 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0310365 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0308459 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0301475 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0297291 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0295825 |
| SEC61G | Sec61 gamma subunit | -0.0291451 |
| RPL34 | ribosomal protein L34 | -0.0290654 |
| OSMR | oncostatin M receptor | -0.0287458 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0284363 |
| CDCP1 | CUB domain containing protein 1 | -0.0280224 |
| AGR2 | anterior gradient 2 | -0.0278364 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0277404 |
| RPL35A | ribosomal protein L35a | -0.0275823 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0269533 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0268272 |
| ABLIM1 | actin binding LIM protein 1 | -0.0263677 |
| CST3 | cystatin C | -0.0258428 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0257989 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0256781 |
| KRT8 | keratin 8, type II | -0.0254579 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0251597 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0249949 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0247091 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0234841 |
| TMEM45B | transmembrane protein 45B | -0.0228455 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0226618 |
| KRT7 | keratin 7, type II | -0.0226212 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0221572 |
| BMP7 | bone morphogenetic protein 7 | -0.021831 |
| LAMB3 | laminin, beta 3 | -0.0216383 |
| HLA-B | major histocompatibility complex, class I, B | -0.0214989 |
| NGLY1 | N-glycanase 1 | -0.0213852 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0205902 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0202644 |
| RPS8 | ribosomal protein S8 | -0.0201208 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0199164 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0199062 |
| RPS25 | ribosomal protein S25 | -0.0197653 |
| S100A9 | S100 calcium binding protein A9 | -0.0197036 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.019562 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0195243 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0194155 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.019136 |
| CPE | carboxypeptidase E | -0.0191032 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0190981 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0189438 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0186081 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0185887 |
| HMGA1 | high mobility group AT-hook 1 | -0.0185079 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0183962 |
| RPLP1 | ribosomal protein, large, P1 | -0.0182994 |
| TKT | transketolase | -0.0182949 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0181415 |
| S100A6 | S100 calcium binding protein A6 | -0.0180801 |
| RPS24 | ribosomal protein S24 | -0.0180687 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0178694 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0178199 |
| PTMA | prothymosin, alpha | -0.0177932 |
| RPL19 | ribosomal protein L19 | -0.0177835 |
| LMAN1 | lectin, mannose-binding, 1 | -0.017721 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0174516 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0171407 |
| NDE1 | nudE neurodevelopment protein 1 | -0.017114 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.016903 |
| GM2A | GM2 ganglioside activator | -0.0167669 |
| GNAS | GNAS complex locus | -0.0164087 |
| RIN2 | Ras and Rab interactor 2 | -0.0162333 |
| KRT19 | keratin 19, type I | -0.016208 |
| S100A11 | S100 calcium binding protein A11 | -0.0161895 |
| WDR45B | WD repeat domain 45B | -0.0158878 |
| RSF1 | remodeling and spacing factor 1 | -0.0158475 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0156011 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0155613 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0154473 |
