| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bimatoprost perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bimatoprost_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.109933 |
| MT2A | metallothionein 2A | 0.0973334 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0959128 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0665258 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0659242 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0638769 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0608711 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0595093 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0578168 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0564958 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0553195 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0523506 |
| WAC | WW domain containing adaptor with coiled-coil | 0.051599 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0498556 |
| RBM39 | RNA binding motif protein 39 | 0.049173 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0489859 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0475933 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0466288 |
| RPLP1 | ribosomal protein, large, P1 | 0.045823 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.044354 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0441283 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0401391 |
| GOLGA4 | golgin A4 | 0.0400502 |
| COPA | coatomer protein complex, subunit alpha | 0.0386113 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0365832 |
| FMNL2 | formin-like 2 | 0.0362747 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0357428 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0348895 |
| PDE10A | phosphodiesterase 10A | 0.034343 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0336064 |
| ATXN1 | ataxin 1 | 0.033107 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0328288 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0312687 |
| UTRN | utrophin | 0.0309777 |
| ZNF638 | zinc finger protein 638 | 0.0307442 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0302889 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0301246 |
| ATF6 | activating transcription factor 6 | 0.0295782 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0292529 |
| RPL7 | ribosomal protein L7 | 0.0291669 |
| CTBP2 | C-terminal binding protein 2 | 0.0291053 |
| MYO1E | myosin IE | 0.0290199 |
| EXOC6B | exocyst complex component 6B | 0.0289989 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0286879 |
| RPL36 | ribosomal protein L36 | 0.0285829 |
| PRELID2 | PRELI domain containing 2 | 0.0282711 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0281997 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0280254 |
| RPL35A | ribosomal protein L35a | 0.0279825 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0278183 |
| RAD51B | RAD51 paralog B | 0.0276807 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0274567 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0274103 |
| HELZ | helicase with zinc finger | 0.0273965 |
| INTS6 | integrator complex subunit 6 | 0.0272696 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.026993 |
| PRKD1 | protein kinase D1 | 0.0269229 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0268915 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0268452 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0266232 |
| MED13 | mediator complex subunit 13 | 0.0266075 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0263874 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.0263475 |
| RPS6 | ribosomal protein S6 | 0.0262743 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0261128 |
| FUS | FUS RNA binding protein | 0.0260707 |
| GOLGB1 | golgin B1 | 0.0254981 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0254807 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0254647 |
| SMAD2 | SMAD family member 2 | 0.0253199 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0250949 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0248433 |
| TOP1 | topoisomerase (DNA) I | 0.0245181 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0243123 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0241253 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0240592 |
| RPS29 | ribosomal protein S29 | 0.0240176 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0239922 |
| PDLIM5 | PDZ and LIM domain 5 | 0.023975 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.023926 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.023838 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0236953 |
| RPL31 | ribosomal protein L31 | 0.0236481 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0232276 |
| TPR | translocated promoter region, nuclear basket protein | 0.0229767 |
| CDK13 | cyclin-dependent kinase 13 | 0.0226524 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0226103 |
| PSEN1 | presenilin 1 | 0.0226044 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0224461 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0224329 |
| RPS19 | ribosomal protein S19 | 0.0223511 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0223389 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0223339 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.022313 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0223106 |
| VRK2 | vaccinia related kinase 2 | 0.0221459 |
| NUMB | numb homolog (Drosophila) | 0.0220423 |
| MSN | moesin | 0.0220402 |
| FTL | ferritin, light polypeptide | 0.0219754 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0219738 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.216563 |
| TXNRD1 | thioredoxin reductase 1 | -0.183079 |
| GRAMD1B | GRAM domain containing 1B | -0.176954 |
| VIM | vimentin | -0.160728 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.133455 |
| FGB | fibrinogen beta chain | -0.105917 |
| IGF2 | insulin-like growth factor 2 | -0.101466 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.094468 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0772685 |
| PKM | pyruvate kinase, muscle | -0.0746621 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0746222 |
| TMSB10 | thymosin beta 10 | -0.0695882 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0680321 |
| S100A6 | S100 calcium binding protein A6 | -0.0667528 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0622549 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0611613 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0606611 |
| UBC | ubiquitin C | -0.0581619 |
| TPM3 | tropomyosin 3 | -0.057505 |
| RPS27A | ribosomal protein S27a | -0.0482615 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0470333 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0461453 |
| HDAC9 | histone deacetylase 9 | -0.0442555 |
| EGR1 | early growth response 1 | -0.0439727 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0433163 |
| OSMR | oncostatin M receptor | -0.0431995 |
| BICC1 | BicC family RNA binding protein 1 | -0.0430882 |
| TAGLN2 | transgelin 2 | -0.0429865 |
| RTN4 | reticulon 4 | -0.0426884 |
| POTEF | POTE ankyrin domain family, member F | -0.0425099 |
| TPM4 | tropomyosin 4 | -0.0418751 |
| ENO1 | enolase 1, (alpha) | -0.0416666 |
| MKI67 | marker of proliferation Ki-67 | -0.0415424 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0388078 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0387724 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.038441 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0380415 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.037736 |
| SVIL | supervillin | -0.0371065 |
| AHNAK | AHNAK nucleoprotein | -0.0367903 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0367776 |
| STC1 | stanniocalcin 1 | -0.0339372 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.033913 |
| SRGN | serglycin | -0.0338966 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0337855 |
| ASPH | aspartate beta-hydroxylase | -0.0337688 |
| LAMB1 | laminin, beta 1 | -0.0337355 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0335793 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0334784 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0330091 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0329479 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0323476 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0317944 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0317154 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0313218 |
| NTN4 | netrin 4 | -0.0313138 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0312813 |
| RHOA | ras homolog family member A | -0.031117 |
| YBX1 | Y box binding protein 1 | -0.030624 |
| LDHA | lactate dehydrogenase A | -0.0303529 |
| LDHB | lactate dehydrogenase B | -0.0302982 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0299635 |
| HDGF | hepatoma-derived growth factor | -0.0295619 |
| AK1 | adenylate kinase 1 | -0.0293846 |
| THBS1 | thrombospondin 1 | -0.0291754 |
| CENPF | centromere protein F, 350/400kDa | -0.0288129 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0286526 |
| PFN1 | profilin 1 | -0.0279353 |
| NAV3 | neuron navigator 3 | -0.0278919 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0276754 |
| MCL1 | myeloid cell leukemia 1 | -0.0275519 |
| ANXA2 | annexin A2 | -0.0274568 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0271352 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0270554 |
| HMGA1 | high mobility group AT-hook 1 | -0.0269718 |
| ACTG1 | actin gamma 1 | -0.0269435 |
| NEGR1 | neuronal growth regulator 1 | -0.0269361 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0264578 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0263939 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0262494 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0261699 |
| TUBB | tubulin, beta class I | -0.025921 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0257803 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0256462 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0254468 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0253182 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.024171 |
| FAM168A | family with sequence similarity 168, member A | -0.0237685 |
| AHR | aryl hydrocarbon receptor | -0.0236886 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0233564 |
| KIFC3 | kinesin family member C3 | -0.0233554 |
| RAI1 | retinoic acid induced 1 | -0.0232748 |
| MAP1B | microtubule-associated protein 1B | -0.0231503 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0230171 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.022521 |
| USP3 | ubiquitin specific peptidase 3 | -0.0222139 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0220318 |
| TUBA1B | tubulin, alpha 1b | -0.0217821 |
| ANLN | anillin, actin binding protein | -0.0216988 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0216822 |
