Bimatoprost_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimatoprost perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

190 genes differentially expressed following the Bimatoprost_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.201203
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.162931
SLTM SAFB-like, transcription modulator 0.157682
PDE10A phosphodiesterase 10A 0.14362
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.134901
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.127396
ELL2 elongation factor, RNA polymerase II, 2 0.126366
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.11731
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.109279
LAMA4 laminin, alpha 4 0.101471
ASPH aspartate beta-hydroxylase 0.0963274
HMGA2 high mobility group AT-hook 2 0.0916086
PSD3 pleckstrin and Sec7 domain containing 3 0.087561
NAMPT nicotinamide phosphoribosyltransferase 0.0801119
NALF1 NALCN channel auxiliary factor 1 0.0789767
DSCAM Down syndrome cell adhesion molecule 0.0762961
ANKRD11 ankyrin repeat domain 11 0.0762557
PDE4D phosphodiesterase 4D, cAMP-specific 0.0754149
AKAP13 A kinase (PRKA) anchor protein 13 0.0747227
KMT2C lysine (K)-specific methyltransferase 2C 0.0713958
RTN4 reticulon 4 0.0698292
TXNRD1 thioredoxin reductase 1 0.0688754
RERE arginine-glutamic acid dipeptide (RE) repeats 0.066005
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0634027
SYT1 synaptotagmin I 0.061434
ENO1 enolase 1, (alpha) 0.0602524
RORA RAR-related orphan receptor A 0.060086
LIMCH1 LIM and calponin homology domains 1 0.0587463
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0568775
CD44 CD44 molecule (Indian blood group) 0.0564864
LAMC2 laminin, gamma 2 0.0549829
SPAG9 sperm associated antigen 9 0.054832
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0496684
FNDC3A fibronectin type III domain containing 3A 0.048269
INTS6 integrator complex subunit 6 0.0468697
SRPK2 SRSF protein kinase 2 0.0464421
AKAP12 A kinase (PRKA) anchor protein 12 0.0457862
ANKRD17 ankyrin repeat domain 17 0.0438575
GCLC glutamate-cysteine ligase, catalytic subunit 0.0428319
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0423558
ZMYND8 zinc finger, MYND-type containing 8 0.0420183
KMT2E lysine (K)-specific methyltransferase 2E 0.0416457
EFNA5 ephrin-A5 0.0390817
DST dystonin 0.0374498
FN1 fibronectin 1 0.036624
EXT1 exostosin glycosyltransferase 1 0.0340542
DOCK4 dedicator of cytokinesis 4 0.033502
TRIO trio Rho guanine nucleotide exchange factor 0.0319221
ESYT2 extended synaptotagmin-like protein 2 0.0309029
B2M beta-2-microglobulin 0.030212
CXCL8 chemokine (C-X-C motif) ligand 8 0.0300417
MYO1E myosin IE 0.0280239
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.027015
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0268227
ANXA2 annexin A2 0.0268108
RICTOR RPTOR independent companion of MTOR, complex 2 0.0263822
RPS12 ribosomal protein S12 0.0259947
CMIP c-Maf inducing protein 0.0232343
PTK2 protein tyrosine kinase 2 0.0219668
FOXP1 forkhead box P1 0.0206785
PDLIM5 PDZ and LIM domain 5 0.0199675
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0197257
RPS6 ribosomal protein S6 0.0186379
SMYD3 SET and MYND domain containing 3 0.018599
DOCK5 dedicator of cytokinesis 5 0.0170551
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0158852
STC1 stanniocalcin 1 0.0151703
CDK6 cyclin-dependent kinase 6 0.0149107
MBD5 methyl-CpG binding domain protein 5 0.0129404
ZSWIM6 zinc finger, SWIM-type containing 6 0.0126532
SAMD4A sterile alpha motif domain containing 4A 0.0119748
FTL ferritin, light polypeptide 0.00984249
EGFR epidermal growth factor receptor 0.00922546
VMP1 vacuole membrane protein 1 0.00908342
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0088485
PRRC2C proline-rich coiled-coil 2C 0.00772874
UBE2K ubiquitin-conjugating enzyme E2K 0.0065888
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.00631942
SBF2 SET binding factor 2 0.00631709
JARID2 jumonji, AT rich interactive domain 2 0.00567881
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.00485582
LOC112694756 uncharaterized LOC112694756 0.00477286
ERBIN erbb2 interacting protein 0.00475631
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00439207
PRELID2 PRELI domain containing 2 0.00424738
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.00414579
ARID4B AT rich interactive domain 4B (RBP1-like) 0.00256075
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0022798
PRKCA protein kinase C, alpha 0.0019861
EZR ezrin 8.97446E-4

decreased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) -0.153942
MAML2 mastermind-like 2 (Drosophila) -0.131892
RPS16 ribosomal protein S16 -0.122861
SNX9 sorting nexin 9 -0.117913
RPLP1 ribosomal protein, large, P1 -0.10433
SRRM2 serine/arginine repetitive matrix 2 -0.0954841
MACF1 microtubule-actin crosslinking factor 1 -0.0931096
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0897244
NAP1L1 nucleosome assembly protein 1-like 1 -0.0891657
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0884383
KAT6B K(lysine) acetyltransferase 6B -0.08607
JMJD1C jumonji domain containing 1C -0.0819311
ZBTB20 zinc finger and BTB domain containing 20 -0.0799189
PGK1 phosphoglycerate kinase 1 -0.078128
PTMA prothymosin, alpha -0.07387
NPC1 Niemann-Pick disease, type C1 -0.0711719
LMO7 LIM domain 7 -0.0711362
TAS2R14 taste receptor, type 2, member 14 -0.0705597
YAP1 Yes-associated protein 1 -0.06842
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0662481
CARD16 caspase recruitment domain family, member 16 -0.0645094
RBM25 RNA binding motif protein 25 -0.0624623
RPS8 ribosomal protein S8 -0.0617011
NDRG1 N-myc downstream regulated 1 -0.0614602
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0610444
ARHGAP12 Rho GTPase activating protein 12 -0.0608478
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0604848
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0601928
MCL1 myeloid cell leukemia 1 -0.056199
RIGI RNA sensor RIG-I -0.0553909
ZFAND3 zinc finger, AN1-type domain 3 -0.0543248
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0536947
NAV2 neuron navigator 2 -0.053205
PTPRM protein tyrosine phosphatase, receptor type, M -0.0522583
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0521348
TBC1D22A TBC1 domain family, member 22A -0.0520931
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.051381
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.051375
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0512346
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0511538
FNDC3B fibronectin type III domain containing 3B -0.0503286
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0498155
CNKSR3 CNKSR family member 3 -0.0481169
WASF2 WAS protein family, member 2 -0.0473435
AFF4 AF4/FMR2 family, member 4 -0.0461841
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0453802
GPC6 glypican 6 -0.0444355
FLNB filamin B, beta -0.0442978
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0440209
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0434235
FMNL2 formin-like 2 -0.0433588
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.042582
NF1 neurofibromin 1 -0.042384
CAMTA1 calmodulin binding transcription activator 1 -0.0416477
KTN1 kinectin 1 (kinesin receptor) -0.0408531
KRT8 keratin 8, type II -0.0407618
EGR1 early growth response 1 -0.0394063
TPT1 tumor protein, translationally-controlled 1 -0.0392049
EIF1 eukaryotic translation initiation factor 1 -0.0384964
ANO6 anoctamin 6 -0.0374218
VIM vimentin -0.0364653
RPL11 ribosomal protein L11 -0.0360047
TMSB10 thymosin beta 10 -0.0355756
RNF213 ring finger protein 213 -0.0353325
FNIP1 folliculin interacting protein 1 -0.0351924
RPLP2 ribosomal protein, large, P2 -0.0348421
ITGA6 integrin, alpha 6 -0.0343889
RPL23 ribosomal protein L23 -0.0338741
PTPRG protein tyrosine phosphatase, receptor type, G -0.033822
MYO5B myosin VB -0.0325734
RPL19 ribosomal protein L19 -0.0321755
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0316014
MBNL1 muscleblind-like splicing regulator 1 -0.0315692
ANKRD28 ankyrin repeat domain 28 -0.0314532
PKM pyruvate kinase, muscle -0.0300124
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0279901
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0263143
SP100 SP100 nuclear antigen -0.0260597
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0256825
SPATA13 spermatogenesis associated 13 -0.0239927
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0236594
MT2A metallothionein 2A -0.0230912
CDH13 cadherin 13 -0.0228037
GOLGA4 golgin A4 -0.0226677
COL6A3 collagen, type VI, alpha 3 -0.0218703
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0204694
GMDS GDP-mannose 4,6-dehydratase -0.0191656
LAMB3 laminin, beta 3 -0.0176765
USP34 ubiquitin specific peptidase 34 -0.0173557
EEF2 eukaryotic translation elongation factor 2 -0.0170079
COL5A2 collagen, type V, alpha 2 -0.0168718
RPL26 ribosomal protein L26 -0.0166065
PARD3 par-3 family cell polarity regulator -0.0164141
RUNX1 runt-related transcription factor 1 -0.0162828
CAMKMT calmodulin-lysine N-methyltransferase -0.0150319
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0149586
STAG2 stromal antigen 2 -0.0148445
BIRC6 baculoviral IAP repeat containing 6 -0.0137083
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0128224
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0112384