Bimiralisib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0884918
SQSTM1 sequestosome 1 0.0800716
HDAC9 histone deacetylase 9 0.057296
RND3 Rho family GTPase 3 0.0547598
SOD2 superoxide dismutase 2, mitochondrial 0.0520296
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0484944
DST dystonin 0.0480815
MBNL2 muscleblind-like splicing regulator 2 0.0420619
RHOBTB3 Rho-related BTB domain containing 3 0.0399543
TXNIP thioredoxin interacting protein 0.0393074
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0391234
ANGPTL7 angiopoietin-like 7 0.0387473
AHNAK2 AHNAK nucleoprotein 2 0.0384247
CSTB cystatin B (stefin B) 0.0337202
AHNAK AHNAK nucleoprotein 0.0323332
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.031015
AUTS2 autism susceptibility candidate 2 0.029948
DSG2 desmoglein 2 0.0292093
NFE2L1 nuclear factor, erythroid 2-like 1 0.0291163
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0290738
HSPB1 heat shock 27kDa protein 1 0.0283597
ANKRD30B ankyrin repeat domain 30B 0.0256576
TNS3 tensin 3 0.0254888
GSE1 Gse1 coiled-coil protein 0.0247136
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0245446
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0242689
ZBTB20 zinc finger and BTB domain containing 20 0.0225846
OPTN optineurin 0.022185
STOM stomatin 0.0221411
FBXL7 F-box and leucine-rich repeat protein 7 0.0220524
MECOM MDS1 and EVI1 complex locus 0.0212811
HLA-E major histocompatibility complex, class I, E 0.0207256
RAB31 RAB31, member RAS oncogene family 0.0207225
TRABD2B TraB domain containing 2B 0.0203544
PLXDC2 plexin domain containing 2 0.0200752
FOXP1 forkhead box P1 0.0198053
CUX1 cut-like homeobox 1 0.0196077
RHOA ras homolog family member A 0.0186987
VMP1 vacuole membrane protein 1 0.0180256
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.0177878
IFI6 interferon, alpha-inducible protein 6 0.0177648
IFI44L interferon-induced protein 44-like 0.01766
NXPH2 neurexophilin 2 0.0173744
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0173655
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0173556
SLFN5 schlafen family member 5 0.0171866
SP100 SP100 nuclear antigen 0.0170425
LMO7 LIM domain 7 0.0169411
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0169332
CRYM crystallin, mu 0.0168665
NCOA7 nuclear receptor coactivator 7 0.0165727
CCDC85A coiled-coil domain containing 85A 0.016292
GASK1B golgi associated kinase 1B 0.0162539
LYST lysosomal trafficking regulator 0.0161857
SYNE2 spectrin repeat containing, nuclear envelope 2 0.016099
GBP2 guanylate binding protein 2, interferon-inducible 0.0158853
IL32 interleukin 32 0.0158391
CFB complement factor B 0.0156924
PTPRB protein tyrosine phosphatase, receptor type, B 0.0154055
SORBS2 sorbin and SH3 domain containing 2 0.0150287
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0150112
NUPR1 nuclear protein, transcriptional regulator, 1 0.0147348
TUFT1 tuftelin 1 0.0145273
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0142405
ANK2 ankyrin 2, neuronal 0.0142173
RPS2 ribosomal protein S2 0.0141464
DSPP dentin sialophosphoprotein 0.0140162
ALCAM activated leukocyte cell adhesion molecule 0.0139193
BBS9 Bardet-Biedl syndrome 9 0.0137595
IFITM3 interferon induced transmembrane protein 3 0.0136967
RABGAP1L RAB GTPase activating protein 1-like 0.0136893
ANTXR1 anthrax toxin receptor 1 0.0135547
TIMP3 TIMP metallopeptidase inhibitor 3 0.0134578
JAK1 Janus kinase 1 0.0130721
MEIS1 Meis homeobox 1 0.0130561
ENAH enabled homolog (Drosophila) 0.0129297
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0128998
IGF1R insulin-like growth factor 1 receptor 0.0127122
CLIP1 CAP-GLY domain containing linker protein 1 0.012521
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0124972
EIF1 eukaryotic translation initiation factor 1 0.0121235
GOPC golgi-associated PDZ and coiled-coil motif containing 0.0120685
OSBPL3 oxysterol binding protein-like 3 0.0119378
PTCHD4 patched domain containing 4 0.0119052
CYLD cylindromatosis (turban tumor syndrome) 0.0118713
BABAM2 BRISC and BRCA1 A complex member 2 0.0118416
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0117753
RASAL2 RAS protein activator like 2 0.0117442
PDLIM5 PDZ and LIM domain 5 0.0116848
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0115794
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0115365
FILIP1L filamin A interacting protein 1-like 0.0113972
RNF213 ring finger protein 213 0.0113464
VAT1 vesicle amine transport 1 0.0113126
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0112318
PMP22 peripheral myelin protein 22 0.0112263
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0112077
PHF3 PHD finger protein 3 0.0109474
PSG4 pregnancy specific beta-1-glycoprotein 4 0.0108969
EXOC4 exocyst complex component 4 0.010874

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.171289
TMSB10 thymosin beta 10 -0.162338
IGFBP3 insulin-like growth factor binding protein 3 -0.156961
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.149805
AKAP12 A kinase (PRKA) anchor protein 12 -0.147405
VIM vimentin -0.13915
MT2A metallothionein 2A -0.132733
LOX lysyl oxidase -0.120654
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.118288
DLG1 discs, large homolog 1 (Drosophila) -0.114089
PLAT plasminogen activator, tissue -0.111156
NAV1 neuron navigator 1 -0.108344
COL5A1 collagen, type V, alpha 1 -0.0906601
CDH13 cadherin 13 -0.0900149
PODXL podocalyxin-like -0.0881622
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0876594
NDRG1 N-myc downstream regulated 1 -0.0870044
CD44 CD44 molecule (Indian blood group) -0.0866565
COL8A1 collagen, type VIII, alpha 1 -0.0802338
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0790893
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.07608
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.075391
FLNB filamin B, beta -0.0753854
LOXL2 lysyl oxidase-like 2 -0.0680307
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0636397
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0599157
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0594726
STC1 stanniocalcin 1 -0.0591098
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0582
MAP1B microtubule-associated protein 1B -0.055916
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0555016
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0544594
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0531269
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.052767
EFNA5 ephrin-A5 -0.0522702
THBS2 thrombospondin 2 -0.0497551
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0496086
PKM pyruvate kinase, muscle -0.0479619
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0476466
RTN4 reticulon 4 -0.046664
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0461207
RUNX1 runt-related transcription factor 1 -0.0456749
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0450079
FN1 fibronectin 1 -0.044119
COL1A2 collagen, type I, alpha 2 -0.0433003
SEPTIN9 septin 9 -0.0432075
SLC39A11 solute carrier family 39, member 11 -0.0423354
TAGLN2 transgelin 2 -0.0418735
MT1X metallothionein 1X -0.0410995
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0409309
WWTR1 WW domain containing transcription regulator 1 -0.0404022
CCND1 cyclin D1 -0.0401501
ELL2 elongation factor, RNA polymerase II, 2 -0.0398656
PSD3 pleckstrin and Sec7 domain containing 3 -0.0394974
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0391659
PRSS23 protease, serine, 23 -0.0390229
PBX3 pre-B-cell leukemia homeobox 3 -0.037908
GLIS3 GLIS family zinc finger 3 -0.0369159
FNDC3B fibronectin type III domain containing 3B -0.0367225
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0362733
ANXA2 annexin A2 -0.0357019
SH3KBP1 SH3-domain kinase binding protein 1 -0.0356057
ASPH aspartate beta-hydroxylase -0.0349619
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0349477
RBM25 RNA binding motif protein 25 -0.0345461
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0337639
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0335906
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0332975
SP3 Sp3 transcription factor -0.0332793
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.032898
FRMD4A FERM domain containing 4A -0.0327023
ZEB1 zinc finger E-box binding homeobox 1 -0.0321502
COL5A2 collagen, type V, alpha 2 -0.0316014
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0313123
LOC112694756 uncharaterized LOC112694756 -0.030817
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0307185
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0303028
BACE2 beta-site APP-cleaving enzyme 2 -0.0300699
LMNA lamin A/C -0.0295629
PLAUR plasminogen activator, urokinase receptor -0.0293778
MRPS6 mitochondrial ribosomal protein S6 -0.0293456
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0291489
DOCK5 dedicator of cytokinesis 5 -0.0290941
DPYSL2 dihydropyrimidinase-like 2 -0.0290831
NAV2 neuron navigator 2 -0.0289915
ABI3BP ABI family, member 3 (NESH) binding protein -0.0286655
GNAS GNAS complex locus -0.0284876
FBN1 fibrillin 1 -0.0284266
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0282938
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.028135
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0280301
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0278356
CEP170 centrosomal protein 170kDa -0.0276223
GARS1 glycyl-tRNA synthetase 1 -0.0273886
MYO9B myosin IXB -0.0269897
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0265728
ACTN4 actinin, alpha 4 -0.0264144
OGA O-GlcNAcase -0.0263596
PDE4D phosphodiesterase 4D, cAMP-specific -0.0258965
ARL4C ADP-ribosylation factor-like 4C -0.0258882