Bimiralisib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.203839
RPS12 ribosomal protein S12 0.112398
CNRIP1 cannabinoid receptor interacting protein 1 0.112011
JMJD1C jumonji domain containing 1C 0.101111
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0994547
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0846394
RPS8 ribosomal protein S8 0.0814091
FTL ferritin, light polypeptide 0.0811565
RPS6 ribosomal protein S6 0.0752493
VMP1 vacuole membrane protein 1 0.0731241
RPS2 ribosomal protein S2 0.0699426
ZSWIM6 zinc finger, SWIM-type containing 6 0.0611267
RPS19 ribosomal protein S19 0.0601146
TPT1 tumor protein, translationally-controlled 1 0.0597639
MMP12 matrix metallopeptidase 12 0.0592542
RPL37A ribosomal protein L37a 0.0573926
RPLP2 ribosomal protein, large, P2 0.0558714
NAP1L1 nucleosome assembly protein 1-like 1 0.0556239
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0555284
RPS23 ribosomal protein S23 0.0528155
EIF1 eukaryotic translation initiation factor 1 0.0525386
RPS3 ribosomal protein S3 0.0505019
RPS29 ribosomal protein S29 0.0494967
RPL12 ribosomal protein L12 0.0481035
YBX3 Y box binding protein 3 0.0459377
RPL36 ribosomal protein L36 0.0451462
RACK1 receptor for activated C kinase 1 0.0439108
NACA nascent polypeptide-associated complex alpha subunit 0.0424387
RPL9 ribosomal protein L9 0.0418161
VIM vimentin 0.0415485
HMGA2 high mobility group AT-hook 2 0.0403696
RPL23 ribosomal protein L23 0.039915
RPL26 ribosomal protein L26 0.0395391
HSPB1 heat shock 27kDa protein 1 0.0393878
RPL31 ribosomal protein L31 0.0386881
RPL37 ribosomal protein L37 0.0384959
NEBL nebulette 0.0384159
ZBTB20 zinc finger and BTB domain containing 20 0.0381169
RPS7 ribosomal protein S7 0.0377298
RPS27 ribosomal protein S27 0.0374965
YAP1 Yes-associated protein 1 0.0366934
PRKCI protein kinase C, iota 0.0366692
NEGR1 neuronal growth regulator 1 0.0354382
PHACTR4 phosphatase and actin regulator 4 0.0348983
RPL19 ribosomal protein L19 0.0347751
RPL5 ribosomal protein L5 0.033736
ANKRD12 ankyrin repeat domain 12 0.0334929
RPL11 ribosomal protein L11 0.0334336
GOLGB1 golgin B1 0.032537
RPL34 ribosomal protein L34 0.0314467
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0305753
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.030568
RPS14 ribosomal protein S14 0.030382
HDAC9 histone deacetylase 9 0.0303596
AKAP9 A kinase (PRKA) anchor protein 9 0.0300964
DSCAM Down syndrome cell adhesion molecule 0.0293235
BPTF bromodomain PHD finger transcription factor 0.0290773
MPG N-methylpurine-DNA glycosylase 0.0288905
MBD5 methyl-CpG binding domain protein 5 0.0287982
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0286979
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0286208
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0286006
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0285378
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0284098
CCDC88A coiled-coil domain containing 88A 0.0284004
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0282908
RPL36A ribosomal protein L36a 0.0281983
UBE2B ubiquitin-conjugating enzyme E2B 0.0281087
NFIB nuclear factor I/B 0.0279207
RPL10A ribosomal protein L10a 0.027689
SOS1 son of sevenless homolog 1 (Drosophila) 0.0276114
ANKRD17 ankyrin repeat domain 17 0.0274464
ALCAM activated leukocyte cell adhesion molecule 0.0272417
FBXO11 F-box protein 11 0.0269699
NIPBL Nipped-B homolog (Drosophila) 0.0267352
RPL7A ribosomal protein L7a 0.0266083
RPL7 ribosomal protein L7 0.0265231
NFE2L2 nuclear factor, erythroid 2-like 2 0.0264739
KLF6 Kruppel-like factor 6 0.0262939
TPI1 triosephosphate isomerase 1 0.0260251
RB1CC1 RB1-inducible coiled-coil 1 0.0257936
SIK3 SIK family kinase 3 0.0257537
NCOA1 nuclear receptor coactivator 1 0.0255206
PHF21A PHD finger protein 21A 0.0252837
RPL32 ribosomal protein L32 0.0248305
ANKRD11 ankyrin repeat domain 11 0.0247519
GATAD2B GATA zinc finger domain containing 2B 0.0246805
RPLP0 ribosomal protein, large, P0 0.0242737
RPS25 ribosomal protein S25 0.0241326
EXOC6B exocyst complex component 6B 0.0240735
KMT2E lysine (K)-specific methyltransferase 2E 0.0238766
MARCHF4 membrane associated ring-CH-type finger 4 0.0238694
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.023526
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.023424
PRRC2C proline-rich coiled-coil 2C 0.0233618
LPP LIM domain containing preferred translocation partner in lipoma 0.0233058
EXT1 exostosin glycosyltransferase 1 0.0229315
MAML3 mastermind-like 3 (Drosophila) 0.0229071
FAM177A1 family with sequence similarity 177, member A1 0.0228903
RPS13 ribosomal protein S13 0.0224977

decreased expression

Symbol Name Standardized Value
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.206082
EGR1 early growth response 1 -0.119949
AREG amphiregulin -0.110845
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0973414
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0895532
BIRC3 baculoviral IAP repeat containing 3 -0.0866192
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0786037
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0762922
ACTG1 actin gamma 1 -0.0738984
ASPH aspartate beta-hydroxylase -0.0725281
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.069456
POTEF POTE ankyrin domain family, member F -0.0687696
HMGA1 high mobility group AT-hook 1 -0.0665285
TUBA1B tubulin, alpha 1b -0.0648705
NHSL1 NHS-like 1 -0.0647695
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0643374
TMEM123 transmembrane protein 123 -0.0623491
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0603235
MGAT4C MGAT4 family, member C -0.0584434
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0579194
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0573018
UBC ubiquitin C -0.0566451
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0563773
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0558417
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0546338
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0539971
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0539165
NLGN1 neuroligin 1 -0.0535202
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0531871
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0517112
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0510817
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0508296
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0497122
RRM2 ribonucleotide reductase M2 -0.0492001
LOC112694756 uncharaterized LOC112694756 -0.0491448
CCN2 cellular communication network factor 2 -0.0485928
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0484873
PTMA prothymosin, alpha -0.0472141
ZNF804A zinc finger protein 804A -0.0458557
EEF2 eukaryotic translation elongation factor 2 -0.0455277
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0451554
RAB7A RAB7A, member RAS oncogene family -0.0448711
PFN1 profilin 1 -0.0438215
HLA-A major histocompatibility complex, class I, A -0.0420606
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0417785
LDHA lactate dehydrogenase A -0.0412081
HSPA4 heat shock 70kDa protein 4 -0.0411922
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.040665
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0405504
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0404861
ECT2 epithelial cell transforming 2 -0.0394982
SLC38A2 solute carrier family 38, member 2 -0.0372175
PCDH7 protocadherin 7 -0.036503
ATP5F1B ATP synthase F1 subunit beta -0.0357696
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0356265
MKI67 marker of proliferation Ki-67 -0.0355018
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0354517
SPDYA speedy/RINGO cell cycle regulator family member A -0.0353042
CANX calnexin -0.0351378
SMC4 structural maintenance of chromosomes 4 -0.0346912
TGM2 transglutaminase 2 -0.034239
LDHB lactate dehydrogenase B -0.0339861
RASAL2 RAS protein activator like 2 -0.0336633
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0335745
TPM3 tropomyosin 3 -0.0331391
TUBA1C tubulin, alpha 1c -0.0328885
PA2G4 proliferation-associated 2G4, 38kDa -0.0326485
SLC38A1 solute carrier family 38, member 1 -0.0321923
YBX1 Y box binding protein 1 -0.0318429
ADGRG6 adhesion G protein-coupled receptor G6 -0.0314018
KPNB1 karyopherin (importin) beta 1 -0.0313498
LMAN1 lectin, mannose-binding, 1 -0.0311076
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0308582
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0308168
TPM4 tropomyosin 4 -0.030559
TUBB tubulin, beta class I -0.0305162
CENPF centromere protein F, 350/400kDa -0.0303676
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.030122
H1-0 H1.0 linker histone -0.0300892
SERBP1 SERPINE1 mRNA binding protein 1 -0.0296007
LMO7 LIM domain 7 -0.0293946
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0290846
HDLBP high density lipoprotein binding protein -0.028327
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0281893
CLDN1 claudin 1 -0.0280925
PLK2 polo-like kinase 2 -0.0279033
ZNF207 zinc finger protein 207 -0.0279032
CLTC clathrin, heavy chain (Hc) -0.0277805
FKBP4 FK506 binding protein 4, 59kDa -0.0277738
NAV3 neuron navigator 3 -0.0277156
ANXA1 annexin A1 -0.0276322
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0272609
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0270594
P3H2 prolyl 3-hydroxylase 2 -0.02679
NECTIN3 nectin cell adhesion molecule 3 -0.0266544
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0265919
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0265736
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0263761
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0263693
EIF4A1 eukaryotic translation initiation factor 4A1 -0.026085