Bimiralisib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.243781
RPS6 ribosomal protein S6 0.168718
VIM vimentin 0.108179
RPL23 ribosomal protein L23 0.107737
ACTG1 actin gamma 1 0.0916602
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0758618
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0751108
B2M beta-2-microglobulin 0.0739949
RPS12 ribosomal protein S12 0.0737757
EIF1 eukaryotic translation initiation factor 1 0.0679949
SYT1 synaptotagmin I 0.0645992
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0633487
PTMA prothymosin, alpha 0.0562998
RPS27 ribosomal protein S27 0.0542448
LINGO2 leucine rich repeat and Ig domain containing 2 0.0539474
RPLP1 ribosomal protein, large, P1 0.0539119
RPS25 ribosomal protein S25 0.0539097
RPL12 ribosomal protein L12 0.0520881
PCBP2 poly(rC) binding protein 2 0.0518838
RACK1 receptor for activated C kinase 1 0.0513557
RPS14 ribosomal protein S14 0.0499073
RPS19 ribosomal protein S19 0.0484722
BPTF bromodomain PHD finger transcription factor 0.0484599
AKAP9 A kinase (PRKA) anchor protein 9 0.0478765
ALCAM activated leukocyte cell adhesion molecule 0.0468138
FTL ferritin, light polypeptide 0.0467872
RPL35A ribosomal protein L35a 0.0467291
RPS8 ribosomal protein S8 0.046192
RPS11 ribosomal protein S11 0.0453613
RPS29 ribosomal protein S29 0.045273
RPS23 ribosomal protein S23 0.0448418
PLPP1 phospholipid phosphatase 1 0.0447205
RPL37A ribosomal protein L37a 0.0447191
RPL36 ribosomal protein L36 0.0445167
RPS3 ribosomal protein S3 0.044105
KTN1 kinectin 1 (kinesin receptor) 0.043946
POTEF POTE ankyrin domain family, member F 0.0432837
RPL19 ribosomal protein L19 0.0432592
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0425007
RPL34 ribosomal protein L34 0.0420893
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0417026
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0383583
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0381766
RPL5 ribosomal protein L5 0.0378089
CALD1 caldesmon 1 0.0372504
AKAP13 A kinase (PRKA) anchor protein 13 0.0356737
DCAF7 DDB1 and CUL4 associated factor 7 0.0355825
RPS2 ribosomal protein S2 0.035498
EEF1G eukaryotic translation elongation factor 1 gamma 0.0345475
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0345376
RPLP0 ribosomal protein, large, P0 0.034494
FN1 fibronectin 1 0.0343898
ENO1 enolase 1, (alpha) 0.0338418
S100A9 S100 calcium binding protein A9 0.0328346
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0328344
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0326699
RPL36A ribosomal protein L36a 0.0324041
RPL7A ribosomal protein L7a 0.0322651
SET SET nuclear proto-oncogene 0.0316475
RPS5 ribosomal protein S5 0.0316333
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0311957
GOLGB1 golgin B1 0.0311084
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0309025
NEK1 NIMA-related kinase 1 0.0308962
RPLP2 ribosomal protein, large, P2 0.0308334
DGKH diacylglycerol kinase, eta 0.0308298
RPS21 ribosomal protein S21 0.0307259
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0307213
RPL7 ribosomal protein L7 0.0307073
RPL31 ribosomal protein L31 0.0298455
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0297625
RPL32 ribosomal protein L32 0.0297257
RPL11 ribosomal protein L11 0.029532
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0295057
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0291688
SIK2 salt-inducible kinase 2 0.0290272
RPL26 ribosomal protein L26 0.0288748
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0288285
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0286097
DST dystonin 0.028389
PALLD palladin, cytoskeletal associated protein 0.0279794
ASPH aspartate beta-hydroxylase 0.0278737
MYOF myoferlin 0.0278546
RPL18 ribosomal protein L18 0.0276894
ZSWIM6 zinc finger, SWIM-type containing 6 0.0268191
TMSB10 thymosin beta 10 0.0266885
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0265153
RPS17 ribosomal protein S17 0.0265137
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0263534
RPS15 ribosomal protein S15 0.0261457
RPL27 ribosomal protein L27 0.0260882
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0259341
VEGFA vascular endothelial growth factor A 0.0256537
TIMP2 TIMP metallopeptidase inhibitor 2 0.0255835
SENP6 SUMO1/sentrin specific peptidase 6 0.0255661
PCM1 pericentriolar material 1 0.0254057
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0252444
LOC102724023 ES1 protein homolog, mitochondrial 0.0249972
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0249945
ARHGAP24 Rho GTPase activating protein 24 0.0249388

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.199543
LSAMP limbic system-associated membrane protein -0.175282
IGF2 insulin-like growth factor 2 -0.10442
FMN1 formin 1 -0.102298
TRIB2 tribbles pseudokinase 2 -0.086564
PTPRD protein tyrosine phosphatase, receptor type, D -0.0692761
EXT1 exostosin glycosyltransferase 1 -0.0674454
NREP neuronal regeneration related protein -0.0655658
MSI2 musashi RNA-binding protein 2 -0.0646701
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0622285
THSD4 thrombospondin, type I, domain containing 4 -0.0557812
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0548178
COL3A1 collagen, type III, alpha 1 -0.0509358
EGR1 early growth response 1 -0.0507657
VCL vinculin -0.050465
DNAH14 dynein, axonemal, heavy chain 14 -0.0465365
PTPRM protein tyrosine phosphatase, receptor type, M -0.0462383
CCDC47 coiled-coil domain containing 47 -0.0456438
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0454629
KDM3A lysine (K)-specific demethylase 3A -0.0441399
NAMPT nicotinamide phosphoribosyltransferase -0.0438966
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0422139
RNF213 ring finger protein 213 -0.0420436
FRMD4A FERM domain containing 4A -0.0400834
SPAG9 sperm associated antigen 9 -0.0391707
PRKCA protein kinase C, alpha -0.0388406
FKBP10 FK506 binding protein 10, 65 kDa -0.0380479
THBS1 thrombospondin 1 -0.0375014
TPM1 tropomyosin 1 (alpha) -0.0368323
HELZ helicase with zinc finger -0.0358059
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0356876
ZNF804A zinc finger protein 804A -0.0334579
MAML2 mastermind-like 2 (Drosophila) -0.0333398
CENPF centromere protein F, 350/400kDa -0.0332644
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.033214
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0330647
NPAS2 neuronal PAS domain protein 2 -0.0322468
GSE1 Gse1 coiled-coil protein -0.0320804
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0320015
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0319315
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0315924
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0306395
NCAM2 neural cell adhesion molecule 2 -0.0303265
RFC3 replication factor C (activator 1) 3, 38kDa -0.0302645
PLAT plasminogen activator, tissue -0.0301782
NCOA7 nuclear receptor coactivator 7 -0.0300889
AOPEP aminopeptidase O (putative) -0.0300152
MAPK10 mitogen-activated protein kinase 10 -0.029287
CLTC clathrin, heavy chain (Hc) -0.0290525
KCNIP4 Kv channel interacting protein 4 -0.0290491
LCORL ligand dependent nuclear receptor corepressor-like -0.0290386
ZMAT3 zinc finger, matrin-type 3 -0.0289182
ADGRG6 adhesion G protein-coupled receptor G6 -0.0288506
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0288491
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0287325
SCLT1 sodium channel and clathrin linker 1 -0.0284612
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0281169
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0279625
COPA coatomer protein complex, subunit alpha -0.0277165
TET1 tet methylcytosine dioxygenase 1 -0.027704
CHD9 chromodomain helicase DNA binding protein 9 -0.0275965
LRP1B low density lipoprotein receptor-related protein 1B -0.0271578
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0271266
SMAD3 SMAD family member 3 -0.0269383
CEP350 centrosomal protein 350kDa -0.0267228
EPAS1 endothelial PAS domain protein 1 -0.0266944
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0261616
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0259163
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.025805
C1ORF21 chromosome 1 open reading frame 21 -0.0255477
UBAP2L ubiquitin associated protein 2-like -0.0254852
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0252705
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0249197
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.024881
GPC5 glypican 5 -0.0247882
TLE4 transducin-like enhancer of split 4 -0.0246854
MED13 mediator complex subunit 13 -0.0245898
FNDC3A fibronectin type III domain containing 3A -0.0245246
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0244855
COL4A5 collagen, type IV, alpha 5 -0.024263
LARP4B La ribonucleoprotein domain family, member 4B -0.0240098
COL4A2 collagen, type IV, alpha 2 -0.0236291
FNBP1 formin binding protein 1 -0.0233192
FOXK2 forkhead box K2 -0.0233078
IARS1 isoleucyl-tRNA synthetase 1 -0.0232313
DENND1A DENN/MADD domain containing 1A -0.0232088
BICD1 bicaudal D homolog 1 (Drosophila) -0.0229467
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.022724
AFF4 AF4/FMR2 family, member 4 -0.0226784
AUTS2 autism susceptibility candidate 2 -0.0225531
FAM13A family with sequence similarity 13, member A -0.022149
COL1A1 collagen, type I, alpha 1 -0.0220419
FHIT fragile histidine triad -0.022036
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0219734
HMGB2 high mobility group box 2 -0.0219373
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0219358
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0218932
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0218805
VAV2 vav 2 guanine nucleotide exchange factor -0.0215612
KPNB1 karyopherin (importin) beta 1 -0.0213252