Bimiralisib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.158881
RPS12 ribosomal protein S12 0.152019
RPS6 ribosomal protein S6 0.151451
DSPP dentin sialophosphoprotein 0.132558
RPL37A ribosomal protein L37a 0.129258
ENO1 enolase 1, (alpha) 0.128942
RPS8 ribosomal protein S8 0.122455
RPL11 ribosomal protein L11 0.119527
IGFBP1 insulin-like growth factor binding protein 1 0.102018
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0822529
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.081462
RPL26 ribosomal protein L26 0.0786823
RPS27A ribosomal protein S27a 0.0781192
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0772561
RPS29 ribosomal protein S29 0.0755851
RPL23 ribosomal protein L23 0.0755809
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.072704
RPL31 ribosomal protein L31 0.067743
TF transferrin 0.0674344
RPS3 ribosomal protein S3 0.0672525
RPS14 ribosomal protein S14 0.0670865
VCL vinculin 0.0633208
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0630848
RACK1 receptor for activated C kinase 1 0.0629915
RPS24 ribosomal protein S24 0.0596665
RPS19 ribosomal protein S19 0.059011
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.058953
RPLP2 ribosomal protein, large, P2 0.0587333
CP ceruloplasmin (ferroxidase) 0.0584682
RPL5 ribosomal protein L5 0.0575127
RPS23 ribosomal protein S23 0.0571331
NAP1L1 nucleosome assembly protein 1-like 1 0.05449
RPL9 ribosomal protein L9 0.0542632
RPS17 ribosomal protein S17 0.0534783
ISG15 ISG15 ubiquitin-like modifier 0.0525775
FTL ferritin, light polypeptide 0.0508243
RPL12 ribosomal protein L12 0.0505781
RPS25 ribosomal protein S25 0.0502266
LMCD1 LIM and cysteine-rich domains 1 0.049701
KLF6 Kruppel-like factor 6 0.0492927
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0492742
B2M beta-2-microglobulin 0.0463864
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0457027
RPLP0 ribosomal protein, large, P0 0.0453389
PDLIM5 PDZ and LIM domain 5 0.044143
ENAH enabled homolog (Drosophila) 0.0425743
RPS13 ribosomal protein S13 0.0425161
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0424666
RPLP1 ribosomal protein, large, P1 0.0424011
RPL19 ribosomal protein L19 0.0421052
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.042085
PTPRK protein tyrosine phosphatase, receptor type, K 0.0410022
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0409228
BPTF bromodomain PHD finger transcription factor 0.0408363
FOXP1 forkhead box P1 0.0405408
RPS10 ribosomal protein S10 0.0404538
DSTN destrin (actin depolymerizing factor) 0.0404176
IFI6 interferon, alpha-inducible protein 6 0.0402277
ANKRD12 ankyrin repeat domain 12 0.0401976
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0401313
PAWR PRKC, apoptosis, WT1, regulator 0.0393024
ITGAV integrin, alpha V 0.0392783
TXNIP thioredoxin interacting protein 0.0392096
CLEC16A C-type lectin domain family 16, member A 0.0387978
RPL34 ribosomal protein L34 0.038611
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0379383
PTCHD4 patched domain containing 4 0.0379256
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0377201
ZBTB20 zinc finger and BTB domain containing 20 0.037663
RPL7 ribosomal protein L7 0.0371674
RPL36 ribosomal protein L36 0.0355343
KYNU kynureninase 0.0352496
CFB complement factor B 0.0350183
EXT1 exostosin glycosyltransferase 1 0.0349886
PRRC2C proline-rich coiled-coil 2C 0.0349015
PTPRF protein tyrosine phosphatase, receptor type, F 0.0345679
KTN1 kinectin 1 (kinesin receptor) 0.0344438
DSCAM Down syndrome cell adhesion molecule 0.0342026
RPL18 ribosomal protein L18 0.0338563
SIK3 SIK family kinase 3 0.0336545
GOLGA4 golgin A4 0.0335547
RPS21 ribosomal protein S21 0.0333756
RPS16 ribosomal protein S16 0.0323602
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.0323101
RPS2 ribosomal protein S2 0.032241
SVIL supervillin 0.0321222
AKR1C1 aldo-keto reductase family 1, member C1 0.0318455
SAMD4A sterile alpha motif domain containing 4A 0.0317502
NACA nascent polypeptide-associated complex alpha subunit 0.0315112
RPL10A ribosomal protein L10a 0.0314778
RPL27 ribosomal protein L27 0.0313344
HNMT histamine N-methyltransferase 0.0313307
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0312212
RPL7A ribosomal protein L7a 0.0311383
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0311252
RPL38 ribosomal protein L38 0.0309955
RPL32 ribosomal protein L32 0.0309745
RPL37 ribosomal protein L37 0.0306443
APOC1 apolipoprotein C-I 0.0305151
RPL21 ribosomal protein L21 0.0305098

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.304119
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.150755
MAML2 mastermind-like 2 (Drosophila) -0.10068
GMDS GDP-mannose 4,6-dehydratase -0.0996177
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0916185
SLC38A2 solute carrier family 38, member 2 -0.0900585
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0837873
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0788188
EHBP1 EH domain binding protein 1 -0.0706016
FNDC3B fibronectin type III domain containing 3B -0.068227
ASPH aspartate beta-hydroxylase -0.0657782
MT2A metallothionein 2A -0.0598674
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0597156
NPAS2 neuronal PAS domain protein 2 -0.0566038
ELL2 elongation factor, RNA polymerase II, 2 -0.0558636
FN1 fibronectin 1 -0.0497344
AKAP12 A kinase (PRKA) anchor protein 12 -0.0488528
EGR1 early growth response 1 -0.0451086
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0428757
NKD1 naked cuticle homolog 1 (Drosophila) -0.0425441
FRMD5 FERM domain containing 5 -0.0423867
ATP10A ATPase, class V, type 10A -0.0416576
ITGB5 integrin, beta 5 -0.0414567
EPAS1 endothelial PAS domain protein 1 -0.0392487
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0388497
FMNL2 formin-like 2 -0.0371341
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0366368
TMEM123 transmembrane protein 123 -0.0360849
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0358093
NHSL1 NHS-like 1 -0.0356524
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0355519
GRB10 growth factor receptor-bound protein 10 -0.0349078
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0334527
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0319549
RUNX1 runt-related transcription factor 1 -0.0317467
SOX5 SRY (sex determining region Y)-box 5 -0.0305789
EML4 echinoderm microtubule associated protein like 4 -0.0299726
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0299621
ARL5B ADP-ribosylation factor-like 5B -0.0296984
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0293497
KDM7A lysine (K)-specific demethylase 7A -0.0287077
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0284143
FBF1 Fas (TNFRSF6) binding factor 1 -0.0282326
FAT1 FAT atypical cadherin 1 -0.0280304
IQSEC1 IQ motif and Sec7 domain 1 -0.027293
MCL1 myeloid cell leukemia 1 -0.0270973
MALT1 MALT1 paracaspase -0.0268179
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0267248
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0266515
HMGA1 high mobility group AT-hook 1 -0.026282
SHB Src homology 2 domain containing adaptor protein B -0.025931
CRLS1 cardiolipin synthase 1 -0.0257006
IGF2 insulin-like growth factor 2 -0.0251146
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0239437
SESTD1 SEC14 and spectrin domains 1 -0.0238765
ICAM1 intercellular adhesion molecule 1 -0.0238532
ACSL5 acyl-CoA synthetase long-chain family member 5 -0.0234644
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.0232464
A2M alpha-2-macroglobulin -0.0228292
KCMF1 potassium channel modulatory factor 1 -0.0228087
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.0226919
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0222291
NDRG1 N-myc downstream regulated 1 -0.0220482
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.021752
JAG1 jagged 1 -0.021703
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0211336
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0210235
HMGA2 high mobility group AT-hook 2 -0.0203032
AGO2 argonaute RISC catalytic component 2 -0.0202152
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0201898
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0200821
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0198451
HPCAL1 hippocalcin-like 1 -0.0198095
NPR2 natriuretic peptide receptor 2 -0.0195056
WDFY2 WD repeat and FYVE domain containing 2 -0.0192236
KIAA1217 KIAA1217 -0.0191631
FAM135A family with sequence similarity 135, member A -0.0191076
ITGA1 integrin, alpha 1 -0.0190465
UBASH3B ubiquitin associated and SH3 domain containing B -0.0188317
HOOK2 hook microtubule-tethering protein 2 -0.0188066
INSIG2 insulin induced gene 2 -0.0188048
STK39 serine threonine kinase 39 -0.0185395
ADAM9 ADAM metallopeptidase domain 9 -0.0184062
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0180806
PDGFB platelet-derived growth factor beta polypeptide -0.0179923
NBAS neuroblastoma amplified sequence -0.017888
LYZ lysozyme -0.0177384
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0176872
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.0174822
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0174722
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.017147
RREB1 ras responsive element binding protein 1 -0.0171322
DOCK5 dedicator of cytokinesis 5 -0.0170774
MSI2 musashi RNA-binding protein 2 -0.0170574
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0170298
TMSB10 thymosin beta 10 -0.0170004
ARHGAP5 Rho GTPase activating protein 5 -0.0165284
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.016424
YAP1 Yes-associated protein 1 -0.0160499
RTN4 reticulon 4 -0.015948