Bimiralisib_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.107035
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.099257
B2M beta-2-microglobulin 0.0838482
RPS6 ribosomal protein S6 0.0694744
FTL ferritin, light polypeptide 0.0679804
DSPP dentin sialophosphoprotein 0.0670546
TPT1 tumor protein, translationally-controlled 1 0.0667065
EIF1 eukaryotic translation initiation factor 1 0.0649029
TMC5 transmembrane channel-like 5 0.0633229
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0622634
RPS12 ribosomal protein S12 0.0600861
MACC1 metastasis associated in colon cancer 1 0.0597565
IFI6 interferon, alpha-inducible protein 6 0.0592606
EXT1 exostosin glycosyltransferase 1 0.0591245
PTPRK protein tyrosine phosphatase, receptor type, K 0.0554915
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0549527
AKAP9 A kinase (PRKA) anchor protein 9 0.0526551
LCN2 lipocalin 2 0.0526518
GOLGB1 golgin B1 0.0521958
EZR ezrin 0.0516318
MBNL2 muscleblind-like splicing regulator 2 0.0505424
FNDC3B fibronectin type III domain containing 3B 0.0495688
TXNIP thioredoxin interacting protein 0.0474003
RPS8 ribosomal protein S8 0.0457748
MYOF myoferlin 0.0451264
RPL23 ribosomal protein L23 0.0449063
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0435404
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0429367
RPS25 ribosomal protein S25 0.0427342
GCLC glutamate-cysteine ligase, catalytic subunit 0.0418753
GOLGA4 golgin A4 0.0405392
RPL26 ribosomal protein L26 0.038881
LOC102724023 ES1 protein homolog, mitochondrial 0.0379751
KLF6 Kruppel-like factor 6 0.0377464
NUPR1 nuclear protein, transcriptional regulator, 1 0.0375169
VMP1 vacuole membrane protein 1 0.0370692
SQSTM1 sequestosome 1 0.0365841
ATF5 activating transcription factor 5 0.0359791
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0355024
RPS19 ribosomal protein S19 0.0341913
IFI27 interferon, alpha-inducible protein 27 0.0330372
RPS3 ribosomal protein S3 0.0328491
ZBTB20 zinc finger and BTB domain containing 20 0.03282
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0325843
SP100 SP100 nuclear antigen 0.0313077
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0309226
MYO1E myosin IE 0.0308259
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0302067
RPS2 ribosomal protein S2 0.0296073
TXNRD1 thioredoxin reductase 1 0.0290355
TJP1 tight junction protein 1 0.0289492
RPL19 ribosomal protein L19 0.028796
ATXN1 ataxin 1 0.0283494
GDA guanine deaminase 0.0279086
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.027234
AKAP13 A kinase (PRKA) anchor protein 13 0.026382
LURAP1L leucine rich adaptor protein 1-like 0.0263559
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0263086
DSTN destrin (actin depolymerizing factor) 0.0258727
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0255338
BPTF bromodomain PHD finger transcription factor 0.025291
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0249627
RPS29 ribosomal protein S29 0.0248403
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0244231
TMEM45B transmembrane protein 45B 0.0242843
RPS27 ribosomal protein S27 0.0240775
ZSWIM6 zinc finger, SWIM-type containing 6 0.0239847
NFE2L2 nuclear factor, erythroid 2-like 2 0.0239472
S100P S100 calcium binding protein P 0.0236752
ANKRD12 ankyrin repeat domain 12 0.0232984
SIK3 SIK family kinase 3 0.0232787
SOS1 son of sevenless homolog 1 (Drosophila) 0.023271
RPL21 ribosomal protein L21 0.0232281
RPL37A ribosomal protein L37a 0.023134
RPL18 ribosomal protein L18 0.0230397
ANXA1 annexin A1 0.0230342
RPS17 ribosomal protein S17 0.0227118
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0226042
CDK13 cyclin-dependent kinase 13 0.0225669
RPL28 ribosomal protein L28 0.0225471
ALCAM activated leukocyte cell adhesion molecule 0.0223955
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0223902
NFE2L1 nuclear factor, erythroid 2-like 1 0.0223223
PRKN parkin RBR E3 ubiquitin protein ligase 0.0222753
MX2 MX dynamin-like GTPase 2 0.0222651
CLDN4 claudin 4 0.0222498
CADPS2 Ca++-dependent secretion activator 2 0.0215988
RPS27A ribosomal protein S27a 0.0210074
MACROD2 MACRO domain containing 2 0.0209804
ASTN2 astrotactin 2 0.0206787
CTNND1 catenin (cadherin-associated protein), delta 1 0.0206348
UBE2H ubiquitin-conjugating enzyme E2H 0.0204912
MYADM myeloid-associated differentiation marker 0.0204651
BCAS3 breast carcinoma amplified sequence 3 0.0204361
SAMD9 sterile alpha motif domain containing 9 0.0203525
BAIAP2L1 BAI1-associated protein 2-like 1 0.020308
RPL7A ribosomal protein L7a 0.0199371
XAF1 XIAP associated factor 1 0.019926
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.01989
JUN jun proto-oncogene 0.0198695

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.289478
FGFR2 fibroblast growth factor receptor 2 -0.285704
GMDS GDP-mannose 4,6-dehydratase -0.209058
CEMIP cell migration inducing protein, hyaluronan binding -0.179414
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0965544
POTEF POTE ankyrin domain family, member F -0.0825682
FLNB filamin B, beta -0.079988
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0788896
FAT1 FAT atypical cadherin 1 -0.0784163
MAML2 mastermind-like 2 (Drosophila) -0.0783234
ITGA6 integrin, alpha 6 -0.0773914
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.075952
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0725058
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0658856
S100A6 S100 calcium binding protein A6 -0.064835
TNIK TRAF2 and NCK interacting kinase -0.0637113
KRT8 keratin 8, type II -0.0617985
TMSB10 thymosin beta 10 -0.0609083
KRT18 keratin 18, type I -0.0571002
EHBP1 EH domain binding protein 1 -0.0559163
ACACA acetyl-CoA carboxylase alpha -0.0526275
PTMA prothymosin, alpha -0.051818
ANLN anillin, actin binding protein -0.0489657
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0472804
ANO1 anoctamin 1, calcium activated chloride channel -0.0465245
ITGB4 integrin, beta 4 -0.0457318
ACTN4 actinin, alpha 4 -0.0444901
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0439936
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0438953
H1-0 H1.0 linker histone -0.0438684
PKM pyruvate kinase, muscle -0.0413736
TMEM123 transmembrane protein 123 -0.0393111
CD46 CD46 molecule, complement regulatory protein -0.0386801
PRKCA protein kinase C, alpha -0.0370452
INSIG1 insulin induced gene 1 -0.0369914
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0363621
ANXA2 annexin A2 -0.0357504
SAMD12 sterile alpha motif domain containing 12 -0.0355857
WDR45B WD repeat domain 45B -0.0348522
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0342517
DLG1 discs, large homolog 1 (Drosophila) -0.0338305
KRT7 keratin 7, type II -0.033278
LYZ lysozyme -0.0320011
S100A10 S100 calcium binding protein A10 -0.0318687
AUTS2 autism susceptibility candidate 2 -0.031584
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.031031
EMP1 epithelial membrane protein 1 -0.0304912
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0301413
TRPS1 trichorhinophalangeal syndrome I -0.0300867
FASN fatty acid synthase -0.029915
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0298817
SMC4 structural maintenance of chromosomes 4 -0.0294245
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0293313
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0293118
SREBF2 sterol regulatory element binding transcription factor 2 -0.0291795
LOC112694756 uncharaterized LOC112694756 -0.0287723
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0283348
RNF43 ring finger protein 43 -0.0271178
HMGA1 high mobility group AT-hook 1 -0.0269412
TFRC transferrin receptor -0.0267174
KLK10 kallikrein-related peptidase 10 -0.0266312
MSI2 musashi RNA-binding protein 2 -0.0265612
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0261054
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0254878
MECOM MDS1 and EVI1 complex locus -0.0254526
CLDN7 claudin 7 -0.0253035
CBX3 chromobox homolog 3 -0.0252418
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0252365
ECT2 epithelial cell transforming 2 -0.0248975
PPARG peroxisome proliferator-activated receptor gamma -0.0246924
ADAM9 ADAM metallopeptidase domain 9 -0.0246742
PGK1 phosphoglycerate kinase 1 -0.0246428
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0242917
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0241533
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0239825
TNS4 tensin 4 -0.0235301
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0235032
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0232262
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0231993
EHF ets homologous factor -0.0230328
NFIA nuclear factor I/A -0.0230081
BCL2L1 BCL2-like 1 -0.0229342
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.022879
NCOR2 nuclear receptor corepressor 2 -0.0227435
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0224143
SULF2 sulfatase 2 -0.0222456
FDPS farnesyl diphosphate synthase -0.0220072
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0219343
TMPRSS4 transmembrane protease, serine 4 -0.0219009
DENND1A DENN/MADD domain containing 1A -0.0216386
SHB Src homology 2 domain containing adaptor protein B -0.0214588
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0212236
TRAK1 trafficking protein, kinesin binding 1 -0.0212204
NEK6 NIMA-related kinase 6 -0.0209658
TPM4 tropomyosin 4 -0.0207956
CCND1 cyclin D1 -0.0206569
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0206488
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0205564
MSMO1 methylsterol monooxygenase 1 -0.0203291
LPIN1 lipin 1 -0.0202495