Bimiralisib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.292893
DST dystonin 0.171388
TP63 tumor protein p63 0.159568
VIM vimentin 0.105054
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.103792
COL5A2 collagen, type V, alpha 2 0.0930676
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0809016
SOD2 superoxide dismutase 2, mitochondrial 0.0781287
MT2A metallothionein 2A 0.0741952
MT1E metallothionein 1E 0.0701106
WARS1 tryptophanyl-tRNA synthetase 1 0.0676954
RPS6 ribosomal protein S6 0.0653306
RPS12 ribosomal protein S12 0.0605693
RPS8 ribosomal protein S8 0.0573879
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0564166
HLA-B major histocompatibility complex, class I, B 0.0559447
BIRC3 baculoviral IAP repeat containing 3 0.0543034
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0478722
APOLD1 apolipoprotein L domain containing 1 0.0462055
RPL12 ribosomal protein L12 0.0461904
B2M beta-2-microglobulin 0.0434728
EGFR epidermal growth factor receptor 0.0414629
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0410475
SQSTM1 sequestosome 1 0.0403796
RPL31 ribosomal protein L31 0.0395482
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0387105
FTL ferritin, light polypeptide 0.0377037
KTN1 kinectin 1 (kinesin receptor) 0.0366778
IFI6 interferon, alpha-inducible protein 6 0.036449
CFB complement factor B 0.0345354
MB21D2 Mab-21 domain containing 2 0.0342218
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0341172
RPS23 ribosomal protein S23 0.0334485
RACK1 receptor for activated C kinase 1 0.0334396
VMP1 vacuole membrane protein 1 0.0327604
ENO1 enolase 1, (alpha) 0.0317197
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0301561
HLA-E major histocompatibility complex, class I, E 0.0299154
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0298753
HLA-A major histocompatibility complex, class I, A 0.0298525
RPL37A ribosomal protein L37a 0.02984
GOLGB1 golgin B1 0.0296753
TPT1 tumor protein, translationally-controlled 1 0.0295358
RPS27 ribosomal protein S27 0.029095
TXNIP thioredoxin interacting protein 0.0288795
RPS19 ribosomal protein S19 0.0286254
RPLP2 ribosomal protein, large, P2 0.0285013
DPYD dihydropyrimidine dehydrogenase 0.0279832
ZFP36L1 ZFP36 ring finger protein-like 1 0.0277306
RPS2 ribosomal protein S2 0.0276963
SP100 SP100 nuclear antigen 0.0275547
RPL36A ribosomal protein L36a 0.0274596
IFIH1 interferon induced with helicase C domain 1 0.0269913
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0266035
RPL23 ribosomal protein L23 0.0262253
RPS25 ribosomal protein S25 0.0262055
RPL36 ribosomal protein L36 0.0262025
HDAC9 histone deacetylase 9 0.0260834
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0250591
ADAR adenosine deaminase, RNA-specific 0.0250006
RPL37 ribosomal protein L37 0.0247706
EPHA4 EPH receptor A4 0.0247628
OPTN optineurin 0.0247274
RPS10 ribosomal protein S10 0.0239412
MYOF myoferlin 0.02384
TNS3 tensin 3 0.0233577
RPL26 ribosomal protein L26 0.0229311
RPS17 ribosomal protein S17 0.0229072
RPS3 ribosomal protein S3 0.0226241
BABAM2 BRISC and BRCA1 A complex member 2 0.0223854
BPTF bromodomain PHD finger transcription factor 0.0222816
RPS29 ribosomal protein S29 0.0222408
CFLAR CASP8 and FADD-like apoptosis regulator 0.0216215
RSAD2 radical S-adenosyl methionine domain containing 2 0.0211889
RPL19 ribosomal protein L19 0.0211586
RPLP1 ribosomal protein, large, P1 0.0209865
PLSCR1 phospholipid scramblase 1 0.0208131
RPL38 ribosomal protein L38 0.0207248
AKAP9 A kinase (PRKA) anchor protein 9 0.0201756
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0201311
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0200722
RPLP0 ribosomal protein, large, P0 0.0200577
ISG15 ISG15 ubiquitin-like modifier 0.01992
RPS14 ribosomal protein S14 0.0197621
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0196697
KLHL24 kelch-like family member 24 0.0193973
RPL7A ribosomal protein L7a 0.0193501
UBC ubiquitin C 0.019328
CEP350 centrosomal protein 350kDa 0.0192255
RPL11 ribosomal protein L11 0.0189255
RPS27A ribosomal protein S27a 0.0189194
JAK1 Janus kinase 1 0.0185363
TRIM56 tripartite motif containing 56 0.0183851
ZBTB1 zinc finger and BTB domain containing 1 0.0182442
RPL39 ribosomal protein L39 0.0181304
N4BP2L2 NEDD4 binding protein 2-like 2 0.0180756
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0178398
SDC4 syndecan 4 0.0176826
RPL5 ribosomal protein L5 0.0176486
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0175759

decreased expression

Symbol Name Standardized Value
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0820874
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0802895
APP amyloid beta (A4) precursor protein -0.0654198
FMNL2 formin-like 2 -0.0606002
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.060121
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0590928
DLG1 discs, large homolog 1 (Drosophila) -0.0530422
TMSB4X thymosin beta 4, X-linked -0.0513488
CAPRIN2 caprin family member 2 -0.0510616
FLNB filamin B, beta -0.0491761
PTK2 protein tyrosine kinase 2 -0.0481748
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0471674
PDE10A phosphodiesterase 10A -0.0469115
CADM2 cell adhesion molecule 2 -0.0468781
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.045674
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0452023
CMIP c-Maf inducing protein -0.0442832
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0434138
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0431379
MACF1 microtubule-actin crosslinking factor 1 -0.0427829
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0427724
RAI1 retinoic acid induced 1 -0.0407803
TMSB10 thymosin beta 10 -0.0399482
POTEF POTE ankyrin domain family, member F -0.0396914
ARHGAP5 Rho GTPase activating protein 5 -0.0395129
LOXL2 lysyl oxidase-like 2 -0.0389538
DOCK11 dedicator of cytokinesis 11 -0.0383441
EHBP1 EH domain binding protein 1 -0.0373932
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0373463
PTMA prothymosin, alpha -0.0373111
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0368542
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0367657
THSD4 thrombospondin, type I, domain containing 4 -0.0367038
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0365798
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0359422
CFAP299 cilia and flagella associated protein 299 -0.0356732
EGR1 early growth response 1 -0.0350121
CD44 CD44 molecule (Indian blood group) -0.034512
ANKRD11 ankyrin repeat domain 11 -0.0337135
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.033138
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0328763
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0323457
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0323112
WSB1 WD repeat and SOCS box containing 1 -0.0319027
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0307604
NHSL1 NHS-like 1 -0.0304007
NAV2 neuron navigator 2 -0.0303542
MTCL1 microtubule crosslinking factor 1 -0.0302742
SPRY4 sprouty homolog 4 (Drosophila) -0.0299339
BIRC6 baculoviral IAP repeat containing 6 -0.0296331
KDM4C lysine (K)-specific demethylase 4C -0.0295849
NPAS2 neuronal PAS domain protein 2 -0.0294154
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0291143
SLC38A2 solute carrier family 38, member 2 -0.0290611
PIAS2 protein inhibitor of activated STAT, 2 -0.0289222
TOP1 topoisomerase (DNA) I -0.0287312
DENND1A DENN/MADD domain containing 1A -0.0286302
PTPRF protein tyrosine phosphatase, receptor type, F -0.0280917
RAB7A RAB7A, member RAS oncogene family -0.0277682
NT5E 5'-nucleotidase, ecto (CD73) -0.0277261
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0274647
CDK6 cyclin-dependent kinase 6 -0.0273751
GARS1 glycyl-tRNA synthetase 1 -0.0272134
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.027144
RBM25 RNA binding motif protein 25 -0.0269245
PODXL podocalyxin-like -0.0268918
CSMD3 CUB and Sushi multiple domains 3 -0.0267187
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0264324
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0256905
TM4SF1 transmembrane 4 L six family member 1 -0.025364
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0253209
SDK1 sidekick cell adhesion molecule 1 -0.0251386
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0247265
PYGB phosphorylase, glycogen; brain -0.0243688
ANTXR2 anthrax toxin receptor 2 -0.0241149
OGA O-GlcNAcase -0.0238804
XPO6 exportin 6 -0.0238364
DPYSL2 dihydropyrimidinase-like 2 -0.0237925
RTTN rotatin -0.0237713
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0237419
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0234483
FAF1 Fas (TNFRSF6) associated factor 1 -0.0233251
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0230289
USP34 ubiquitin specific peptidase 34 -0.0230025
EFNA5 ephrin-A5 -0.022983
BCAR3 breast cancer anti-estrogen resistance 3 -0.0229438
ZEB1 zinc finger E-box binding homeobox 1 -0.0229398
TFRC transferrin receptor -0.0228423
ACTN1 actinin, alpha 1 -0.0225941
MCTP1 multiple C2 domains, transmembrane 1 -0.0225318
TXNRD1 thioredoxin reductase 1 -0.0225286
STK17A serine/threonine kinase 17a -0.0225255
EXOC4 exocyst complex component 4 -0.022443
GSK3B glycogen synthase kinase 3 beta -0.0221361
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0220039
GLS2 glutaminase 2 (liver, mitochondrial) -0.021885
KDM4B lysine (K)-specific demethylase 4B -0.0216261
SBF2 SET binding factor 2 -0.0215295
MDN1 MDN1, midasin homolog (yeast) -0.0213707
IARS1 isoleucyl-tRNA synthetase 1 -0.0212142