| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bimiralisib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bimiralisib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.249061 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.114862 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0873239 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0814088 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0795973 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.077892 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0769314 |
| FAM13A | family with sequence similarity 13, member A | 0.060231 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.060055 |
| JMJD1C | jumonji domain containing 1C | 0.051399 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0507224 |
| VMP1 | vacuole membrane protein 1 | 0.0504279 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0445074 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0440193 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0411816 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0388545 |
| ARRDC3 | arrestin domain containing 3 | 0.0369552 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0369327 |
| CPE | carboxypeptidase E | 0.0368972 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0349834 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.034224 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0327172 |
| SPAG9 | sperm associated antigen 9 | 0.0324005 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0319654 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0317913 |
| RPS2 | ribosomal protein S2 | 0.0310893 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0309581 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0308413 |
| RPS12 | ribosomal protein S12 | 0.0305213 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0300261 |
| GOLGB1 | golgin B1 | 0.029374 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.029314 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0292814 |
| PCBP2 | poly(rC) binding protein 2 | 0.0289686 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0289111 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0283195 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0283101 |
| KYNU | kynureninase | 0.0279256 |
| GOLGA4 | golgin A4 | 0.0277624 |
| ZNF638 | zinc finger protein 638 | 0.0271897 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0271231 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0271183 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0263211 |
| DOCK5 | dedicator of cytokinesis 5 | 0.02613 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0255167 |
| RPS3 | ribosomal protein S3 | 0.0248564 |
| NGLY1 | N-glycanase 1 | 0.0244889 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0243454 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0241088 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0239113 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0238457 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0237835 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0237111 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0237042 |
| SIK3 | SIK family kinase 3 | 0.0236359 |
| RPS6 | ribosomal protein S6 | 0.0235375 |
| B2M | beta-2-microglobulin | 0.0233466 |
| BPTF | bromodomain PHD finger transcription factor | 0.0230127 |
| CCNH | cyclin H | 0.0227787 |
| TMF1 | TATA element modulatory factor 1 | 0.0225689 |
| PRELID2 | PRELI domain containing 2 | 0.0221486 |
| RNF145 | ring finger protein 145 | 0.0221128 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0217517 |
| AHR | aryl hydrocarbon receptor | 0.0216922 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0216838 |
| SUCO | SUN domain containing ossification factor | 0.0213498 |
| GPHN | gephyrin | 0.0212701 |
| WDR26 | WD repeat domain 26 | 0.0212005 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0211901 |
| ATF6 | activating transcription factor 6 | 0.0211429 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0204421 |
| HELZ | helicase with zinc finger | 0.020373 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0201109 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0199573 |
| MAP7 | microtubule-associated protein 7 | 0.0197272 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0196499 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0196366 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0194872 |
| KIAA1217 | KIAA1217 | 0.0194391 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0191569 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0190727 |
| CES1 | carboxylesterase 1 | 0.0190538 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.018686 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0186669 |
| MYO6 | myosin VI | 0.018641 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0185454 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0181915 |
| BMP6 | bone morphogenetic protein 6 | 0.0181703 |
| TES | testin LIM domain protein | 0.0181515 |
| RBM39 | RNA binding motif protein 39 | 0.0179108 |
| RPS8 | ribosomal protein S8 | 0.0178895 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0176767 |
| DENND4A | DENN/MADD domain containing 4A | 0.0176729 |
| RAD51B | RAD51 paralog B | 0.0176646 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0176334 |
| ZNF292 | zinc finger protein 292 | 0.0173433 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0173371 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0173057 |
| PER2 | period circadian clock 2 | 0.0172637 |
| DTNA | dystrobrevin, alpha | 0.0170772 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.244874 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.2065 |
| ASPH | aspartate beta-hydroxylase | -0.202461 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.185107 |
| TMSB10 | thymosin beta 10 | -0.160669 |
| LAMC2 | laminin, gamma 2 | -0.14 |
| ACTG1 | actin gamma 1 | -0.116514 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0916981 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0838418 |
| ANXA2 | annexin A2 | -0.0835791 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0830168 |
| PKM | pyruvate kinase, muscle | -0.080628 |
| KRT18 | keratin 18, type I | -0.080062 |
| SCEL | sciellin | -0.0775147 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0727115 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0720926 |
| LAMA4 | laminin, alpha 4 | -0.0661744 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0656456 |
| AHNAK | AHNAK nucleoprotein | -0.0650532 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0629723 |
| LDHA | lactate dehydrogenase A | -0.0607882 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0607679 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0586228 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0563446 |
| S100A10 | S100 calcium binding protein A10 | -0.0547607 |
| TXNRD1 | thioredoxin reductase 1 | -0.0541395 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0540587 |
| OSMR | oncostatin M receptor | -0.0540187 |
| FLNB | filamin B, beta | -0.0534761 |
| H1-0 | H1.0 linker histone | -0.0528693 |
| CCND1 | cyclin D1 | -0.050626 |
| NPAS2 | neuronal PAS domain protein 2 | -0.048103 |
| RNF213 | ring finger protein 213 | -0.0477878 |
| KRT8 | keratin 8, type II | -0.0476591 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0474249 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0471567 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0470109 |
| KRT7 | keratin 7, type II | -0.0463999 |
| CP | ceruloplasmin (ferroxidase) | -0.0460282 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0458882 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0456415 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0454777 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0444866 |
| LAMB3 | laminin, beta 3 | -0.0437067 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0427316 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0394102 |
| INTS6 | integrator complex subunit 6 | -0.0392359 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0390154 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0386781 |
| NABP1 | nucleic acid binding protein 1 | -0.038584 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0384661 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0381252 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0378538 |
| GRAMD1B | GRAM domain containing 1B | -0.0378261 |
| PRKCA | protein kinase C, alpha | -0.0372005 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0368498 |
| POTEF | POTE ankyrin domain family, member F | -0.0355567 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0350689 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0347777 |
| SDC1 | syndecan 1 | -0.0346212 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0332284 |
| MYO1D | myosin ID | -0.0331352 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0328535 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0327038 |
| PLEC | plectin | -0.0322726 |
| CUX1 | cut-like homeobox 1 | -0.0322482 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0321492 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0321324 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0320963 |
| TPM4 | tropomyosin 4 | -0.0320779 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0312096 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0306456 |
| PTMA | prothymosin, alpha | -0.0303654 |
| LMO7 | LIM domain 7 | -0.0302369 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0300265 |
| EGR1 | early growth response 1 | -0.0300248 |
| AMOTL1 | angiomotin like 1 | -0.0298378 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.02958 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0293891 |
| ITGA6 | integrin, alpha 6 | -0.0292245 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0288871 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0280559 |
| MCL1 | myeloid cell leukemia 1 | -0.0274481 |
| EHBP1 | EH domain binding protein 1 | -0.0272133 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0272049 |
| EFNA5 | ephrin-A5 | -0.027195 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0271079 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0271075 |
| HMGA1 | high mobility group AT-hook 1 | -0.0270705 |
| GM2A | GM2 ganglioside activator | -0.0270008 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0267377 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0267303 |
| RIN2 | Ras and Rab interactor 2 | -0.026228 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0261739 |
| SDC4 | syndecan 4 | -0.0260531 |
| PTK2 | protein tyrosine kinase 2 | -0.0259453 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0256575 |
| DSG2 | desmoglein 2 | -0.0254672 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.0252694 |
| FERMT1 | fermitin family member 1 | -0.0252308 |
