Bimiralisib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.147664
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.142161
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0963407
IFI44L interferon-induced protein 44-like 0.0803206
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0653374
VIM vimentin 0.0642463
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0637191
B2M beta-2-microglobulin 0.0631277
GLCCI1 glucocorticoid induced 1 0.0608524
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0552404
IFI6 interferon, alpha-inducible protein 6 0.0515557
RPS6 ribosomal protein S6 0.0511404
RPS12 ribosomal protein S12 0.0493451
SDK1 sidekick cell adhesion molecule 1 0.0476551
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0474806
ASPH aspartate beta-hydroxylase 0.0470432
SP100 SP100 nuclear antigen 0.0452965
MT2A metallothionein 2A 0.0439212
RPS8 ribosomal protein S8 0.043276
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0430971
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0423463
RPL31 ribosomal protein L31 0.0421759
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0417355
ZSWIM6 zinc finger, SWIM-type containing 6 0.0415693
RPS19 ribosomal protein S19 0.0414752
AADAC arylacetamide deacetylase 0.0413383
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0411266
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0395243
INTS6 integrator complex subunit 6 0.0382754
NAP1L1 nucleosome assembly protein 1-like 1 0.0378642
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0373736
PLIN2 perilipin 2 0.0366592
SAMD9 sterile alpha motif domain containing 9 0.0364396
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0355952
RPL37A ribosomal protein L37a 0.0354941
RPS29 ribosomal protein S29 0.0354748
MX2 MX dynamin-like GTPase 2 0.0354606
SQSTM1 sequestosome 1 0.0349671
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0344467
RPS27 ribosomal protein S27 0.0343901
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0340116
KTN1 kinectin 1 (kinesin receptor) 0.0340089
FN1 fibronectin 1 0.0336785
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0336406
ANGPTL4 angiopoietin-like 4 0.0333687
RPS17 ribosomal protein S17 0.033228
EXT1 exostosin glycosyltransferase 1 0.0330765
TPT1 tumor protein, translationally-controlled 1 0.0326937
PTPRB protein tyrosine phosphatase, receptor type, B 0.0319451
RPL36 ribosomal protein L36 0.0318792
NAV2 neuron navigator 2 0.0312338
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0311285
MX1 MX dynamin-like GTPase 1 0.0311187
CA12 carbonic anhydrase XII 0.0310524
RPLP1 ribosomal protein, large, P1 0.0306502
RPLP2 ribosomal protein, large, P2 0.030511
ALCAM activated leukocyte cell adhesion molecule 0.0303982
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0300977
RPL23 ribosomal protein L23 0.0300921
ANKRD28 ankyrin repeat domain 28 0.0295621
STXBP5 syntaxin binding protein 5 (tomosyn) 0.029005
CUX1 cut-like homeobox 1 0.0288731
RPS25 ribosomal protein S25 0.0282334
HDAC9 histone deacetylase 9 0.0282175
RPL11 ribosomal protein L11 0.0281863
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0280471
FTL ferritin, light polypeptide 0.027281
ENO1 enolase 1, (alpha) 0.0269067
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0268768
TIMP1 TIMP metallopeptidase inhibitor 1 0.0261389
FBN1 fibrillin 1 0.0260646
PMP22 peripheral myelin protein 22 0.0256111
RPL32 ribosomal protein L32 0.0254851
WWOX WW domain containing oxidoreductase 0.0253876
RAD51B RAD51 paralog B 0.0253775
DST dystonin 0.0252711
RND3 Rho family GTPase 3 0.0248286
TPST1 tyrosylprotein sulfotransferase 1 0.0247161
IFITM3 interferon induced transmembrane protein 3 0.0246653
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0245259
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0243096
IGFBP3 insulin-like growth factor binding protein 3 0.024185
MTSS1 metastasis suppressor 1 0.024157
RACK1 receptor for activated C kinase 1 0.0240611
RIGI RNA sensor RIG-I 0.0239451
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0238984
RPL28 ribosomal protein L28 0.0237723
IFITM1 interferon induced transmembrane protein 1 0.0236219
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0233409
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0233184
RPL37 ribosomal protein L37 0.0230478
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0229439
ISG15 ISG15 ubiquitin-like modifier 0.0229214
SAMD9L sterile alpha motif domain containing 9-like 0.0229147
RPS3 ribosomal protein S3 0.0224204
RPS13 ribosomal protein S13 0.0222381
LRMDA leucine rich melanocyte differentiation associated 0.0221955
IFIH1 interferon induced with helicase C domain 1 0.02211
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0220923
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0219712

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.264599
RBM39 RNA binding motif protein 39 -0.101865
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0983034
GOLGA4 golgin A4 -0.0959043
CD44 CD44 molecule (Indian blood group) -0.0892195
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0866023
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0846846
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0821495
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0799062
GRB10 growth factor receptor-bound protein 10 -0.0702379
OSMR oncostatin M receptor -0.0688302
NPC1 Niemann-Pick disease, type C1 -0.0672412
LMAN1 lectin, mannose-binding, 1 -0.0662757
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0655138
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0637967
KMT2C lysine (K)-specific methyltransferase 2C -0.0636144
ELL2 elongation factor, RNA polymerase II, 2 -0.0602365
KDM3A lysine (K)-specific demethylase 3A -0.0586848
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.057674
USP34 ubiquitin specific peptidase 34 -0.0545885
OGA O-GlcNAcase -0.0539734
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0537276
UBA6 ubiquitin-like modifier activating enzyme 6 -0.05179
ATP13A3 ATPase type 13A3 -0.0507586
KDM2A lysine (K)-specific demethylase 2A -0.0505545
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0484734
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0483728
PDE4D phosphodiesterase 4D, cAMP-specific -0.0479676
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.046736
SPAG9 sperm associated antigen 9 -0.0456654
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0450627
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0444386
FBXL13 F-box and leucine-rich repeat protein 13 -0.0440719
COPA coatomer protein complex, subunit alpha -0.041411
COG5 component of oligomeric golgi complex 5 -0.0410615
BIRC6 baculoviral IAP repeat containing 6 -0.0408418
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0405885
RAB27B RAB27B, member RAS oncogene family -0.0405092
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0403598
PID1 phosphotyrosine interaction domain containing 1 -0.0401703
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0398625
SBF2 SET binding factor 2 -0.0396745
USP3 ubiquitin specific peptidase 3 -0.0390148
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0389105
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0388686
FAM13A family with sequence similarity 13, member A -0.0387664
NCOA7 nuclear receptor coactivator 7 -0.0385953
ZMYND8 zinc finger, MYND-type containing 8 -0.0383314
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0379308
RAP1B RAP1B, member of RAS oncogene family -0.0375813
MON2 MON2 homolog (S. cerevisiae) -0.0373803
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0367277
CD109 CD109 molecule -0.0365114
HDLBP high density lipoprotein binding protein -0.0363128
MORF4L2 mortality factor 4 like 2 -0.0362052
SEC31A SEC31 homolog A (S. cerevisiae) -0.0361654
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0361218
NBAS neuroblastoma amplified sequence -0.0359647
AKAP13 A kinase (PRKA) anchor protein 13 -0.0349066
ZNF292 zinc finger protein 292 -0.0348977
SETD5 SET domain containing 5 -0.0345713
ARF4 ADP-ribosylation factor 4 -0.0344801
CDK17 cyclin-dependent kinase 17 -0.034219
SRP54 signal recognition particle 54kDa -0.0339269
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0339127
MARCHF6 membrane associated ring-CH-type finger 6 -0.0331746
MRPS6 mitochondrial ribosomal protein S6 -0.032306
RB1CC1 RB1-inducible coiled-coil 1 -0.0321142
FOXO3 forkhead box O3 -0.0319583
EGR1 early growth response 1 -0.031782
OXSR1 oxidative stress responsive 1 -0.0315075
COL12A1 collagen, type XII, alpha 1 -0.0313681
WDR45B WD repeat domain 45B -0.0310894
ZFC3H1 zinc finger, C3H1-type containing -0.0307562
ZFAND3 zinc finger, AN1-type domain 3 -0.030695
SEC23A Sec23 homolog A (S. cerevisiae) -0.0305502
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0304938
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0298728
CALU calumenin -0.0298384
GPC6 glypican 6 -0.029829
LRRC49 leucine rich repeat containing 49 -0.0295975
RAB5A RAB5A, member RAS oncogene family -0.029424
GCC2 GRIP and coiled-coil domain containing 2 -0.0292294
MAP1B microtubule-associated protein 1B -0.0292225
TBC1D15 TBC1 domain family, member 15 -0.0290939
ABI1 abl-interactor 1 -0.0285298
RNF149 ring finger protein 149 -0.028451
AFF4 AF4/FMR2 family, member 4 -0.0282478
BASP1 brain abundant, membrane attached signal protein 1 -0.0281963
NF1 neurofibromin 1 -0.0279026
SUCO SUN domain containing ossification factor -0.0278263
HELZ helicase with zinc finger -0.0277833
FNDC3B fibronectin type III domain containing 3B -0.0277085
PRRC2C proline-rich coiled-coil 2C -0.0274083
SEC24A SEC24 family member A -0.0271727
YME1L1 YME1-like 1 ATPase -0.0271199
TRIO trio Rho guanine nucleotide exchange factor -0.027104
ITCH itchy E3 ubiquitin protein ligase -0.0270835
IER3 immediate early response 3 -0.0268523
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0267128