Bimiralisib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.240038
MT2A metallothionein 2A 0.0880987
RPL23 ribosomal protein L23 0.0860256
RPS12 ribosomal protein S12 0.0852255
RPS8 ribosomal protein S8 0.0843528
FTL ferritin, light polypeptide 0.0810921
FGB fibrinogen beta chain 0.0761748
EIF1 eukaryotic translation initiation factor 1 0.0755078
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0673102
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0656185
AKAP12 A kinase (PRKA) anchor protein 12 0.0654367
RPL37A ribosomal protein L37a 0.0546938
RPS19 ribosomal protein S19 0.0524996
RPL19 ribosomal protein L19 0.0507843
RPL36 ribosomal protein L36 0.0473259
RPL31 ribosomal protein L31 0.045147
RPS29 ribosomal protein S29 0.0448163
RPS3 ribosomal protein S3 0.0445515
RPS2 ribosomal protein S2 0.0442421
CLU clusterin 0.0435453
FGA fibrinogen alpha chain 0.0427582
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.042459
RPS27 ribosomal protein S27 0.0419761
NTN4 netrin 4 0.0410526
RPL32 ribosomal protein L32 0.039682
RPL18 ribosomal protein L18 0.0389974
KYNU kynureninase 0.0382077
RPS6 ribosomal protein S6 0.0370132
NFE2L2 nuclear factor, erythroid 2-like 2 0.0363245
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0358166
RPS23 ribosomal protein S23 0.0356813
RPL11 ribosomal protein L11 0.035145
CNRIP1 cannabinoid receptor interacting protein 1 0.0346358
RPS21 ribosomal protein S21 0.0344412
RPS25 ribosomal protein S25 0.0329651
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0327382
B2M beta-2-microglobulin 0.0313658
RPL28 ribosomal protein L28 0.0306628
RPL26 ribosomal protein L26 0.0304563
RPS17 ribosomal protein S17 0.0303899
RPL7 ribosomal protein L7 0.0302682
RPS15 ribosomal protein S15 0.0301792
RPL12 ribosomal protein L12 0.0298781
RPLP2 ribosomal protein, large, P2 0.0297013
RPL37 ribosomal protein L37 0.0284865
BASP1 brain abundant, membrane attached signal protein 1 0.0279791
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02622
FGG fibrinogen gamma chain 0.0260146
ASTN2 astrotactin 2 0.0246809
RPS11 ribosomal protein S11 0.0234169
RPS14 ribosomal protein S14 0.0234136
RPS10 ribosomal protein S10 0.023347
RPS7 ribosomal protein S7 0.0232397
RPS27A ribosomal protein S27a 0.023227
RPL8 ribosomal protein L8 0.0229409
RPL36A ribosomal protein L36a 0.0225224
NNMT nicotinamide N-methyltransferase 0.0224161
DSCAM Down syndrome cell adhesion molecule 0.022251
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.021272
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0212562
H1-2 H1.2 linker histone, cluster member 0.0206946
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0201761
PRRC2C proline-rich coiled-coil 2C 0.0198915
MYOF myoferlin 0.0193263
RPL21 ribosomal protein L21 0.0193204
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0191475
SIK3 SIK family kinase 3 0.018994
SON SON DNA binding protein 0.0187678
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0186953
AKAP9 A kinase (PRKA) anchor protein 9 0.0185351
PDE4D phosphodiesterase 4D, cAMP-specific 0.017937
PHF3 PHD finger protein 3 0.0178871
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0176165
NAP1L1 nucleosome assembly protein 1-like 1 0.017551
RPL9 ribosomal protein L9 0.017487
RACK1 receptor for activated C kinase 1 0.0174561
GPX4 glutathione peroxidase 4 0.0173819
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0173155
SERF2 small EDRK-rich factor 2 0.0172289
ATP5F1E ATP synthase F1 subunit epsilon 0.0171339
ALCAM activated leukocyte cell adhesion molecule 0.017121
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0170053
RPS5 ribosomal protein S5 0.0169868
CCL5 chemokine (C-C motif) ligand 5 0.0169677
RPLP0 ribosomal protein, large, P0 0.0168045
KTN1 kinectin 1 (kinesin receptor) 0.016718
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0165568
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0162629
UBE2B ubiquitin-conjugating enzyme E2B 0.0161576
TPI1 triosephosphate isomerase 1 0.0161402
CHD1 chromodomain helicase DNA binding protein 1 0.0161118
BRD2 bromodomain containing 2 0.0160307
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0159229
GOLGB1 golgin B1 0.0158351
SRRM1 serine/arginine repetitive matrix 1 0.0157422
RPL23A ribosomal protein L23a 0.0157231
BBX bobby sox homolog (Drosophila) 0.0154904
PDE10A phosphodiesterase 10A 0.0154596
RBBP6 retinoblastoma binding protein 6 0.0151766
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0150885

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.223036
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.171767
THSD4 thrombospondin, type I, domain containing 4 -0.152224
DOCK4 dedicator of cytokinesis 4 -0.144559
IGF2 insulin-like growth factor 2 -0.127639
POTEF POTE ankyrin domain family, member F -0.115062
CMIP c-Maf inducing protein -0.111356
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.110258
GRAMD1B GRAM domain containing 1B -0.10663
FTH1 ferritin, heavy polypeptide 1 -0.104326
PYGL phosphorylase, glycogen, liver -0.0972872
PKM pyruvate kinase, muscle -0.0970314
FMNL2 formin-like 2 -0.0936916
ACTG1 actin gamma 1 -0.093433
TM4SF1 transmembrane 4 L six family member 1 -0.0917509
IGFBP3 insulin-like growth factor binding protein 3 -0.0905312
SAMD4A sterile alpha motif domain containing 4A -0.0895164
VIM vimentin -0.0866814
EGR1 early growth response 1 -0.0841416
MCL1 myeloid cell leukemia 1 -0.0830212
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0800902
FLNB filamin B, beta -0.077636
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0772152
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0716966
DST dystonin -0.0697624
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0567476
ACTN1 actinin, alpha 1 -0.0566121
TRIO trio Rho guanine nucleotide exchange factor -0.0559309
IER3 immediate early response 3 -0.0551122
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0524419
S100A6 S100 calcium binding protein A6 -0.0496351
P4HB prolyl 4-hydroxylase, beta polypeptide -0.049471
ASPH aspartate beta-hydroxylase -0.0485231
PTMA prothymosin, alpha -0.0484218
TMSB10 thymosin beta 10 -0.0481258
MACF1 microtubule-actin crosslinking factor 1 -0.0478746
AK1 adenylate kinase 1 -0.0475298
NAV3 neuron navigator 3 -0.0472139
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0470135
LDHA lactate dehydrogenase A -0.0465034
TFPI2 tissue factor pathway inhibitor 2 -0.0457638
UBASH3B ubiquitin associated and SH3 domain containing B -0.0456173
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0450348
RAD51B RAD51 paralog B -0.0443334
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0437682
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0431699
ANXA2 annexin A2 -0.0423256
STC1 stanniocalcin 1 -0.0419786
APP amyloid beta (A4) precursor protein -0.0412381
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0409534
TPM4 tropomyosin 4 -0.0397715
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0391488
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0387691
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0382278
EGFR epidermal growth factor receptor -0.0381375
COPA coatomer protein complex, subunit alpha -0.0380778
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0380365
TTC28 tetratricopeptide repeat domain 28 -0.0376725
USP34 ubiquitin specific peptidase 34 -0.0375485
SOD2 superoxide dismutase 2, mitochondrial -0.0375123
UTRN utrophin -0.0370554
PARD3 par-3 family cell polarity regulator -0.0362122
CAVIN1 caveolae associated protein 1 -0.0358531
NRG1 neuregulin 1 -0.0358387
RPL35A ribosomal protein L35a -0.0350565
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0346829
MAML3 mastermind-like 3 (Drosophila) -0.0344842
KPNB1 karyopherin (importin) beta 1 -0.0342092
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.034174
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0338243
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0336015
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.033591
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0335734
HMGA1 high mobility group AT-hook 1 -0.0335144
FLNA filamin A, alpha -0.0324903
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0323263
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0320663
FKBP10 FK506 binding protein 10, 65 kDa -0.0317069
MAP1B microtubule-associated protein 1B -0.0312881
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0311204
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0310276
NHSL1 NHS-like 1 -0.0309845
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0307519
LPP LIM domain containing preferred translocation partner in lipoma -0.0306261
GLIS3 GLIS family zinc finger 3 -0.0305119
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0304296
ANGPTL4 angiopoietin-like 4 -0.0304113
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0303384
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0302559
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0299461
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0296777
NUMB numb homolog (Drosophila) -0.0294324
HDAC9 histone deacetylase 9 -0.0291105
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0291077
PFKP phosphofructokinase, platelet -0.0287417
SNX14 sorting nexin 14 -0.0286082
ZBTB20 zinc finger and BTB domain containing 20 -0.0285291
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0284379
C15ORF48 chromosome 15 open reading frame 48 -0.0281172
GLG1 golgi glycoprotein 1 -0.0280868