Bimiralisib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0938822
RPS8 ribosomal protein S8 0.0809741
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0714611
RPS12 ribosomal protein S12 0.0651926
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0614653
RPL7 ribosomal protein L7 0.0583845
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0563082
RPS6 ribosomal protein S6 0.0543963
WWOX WW domain containing oxidoreductase 0.0516198
SYT1 synaptotagmin I 0.0494561
NKD1 naked cuticle homolog 1 (Drosophila) 0.0488989
RABGAP1L RAB GTPase activating protein 1-like 0.0486495
TPT1 tumor protein, translationally-controlled 1 0.0475127
FTH1 ferritin, heavy polypeptide 1 0.0473685
VCL vinculin 0.0442722
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0441926
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0441802
RPS27A ribosomal protein S27a 0.0437953
RPL37A ribosomal protein L37a 0.0426007
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0418149
KTN1 kinectin 1 (kinesin receptor) 0.0401281
RPL26 ribosomal protein L26 0.0400801
SAMD12 sterile alpha motif domain containing 12 0.0397395
TNRC6B trinucleotide repeat containing 6B 0.0389532
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.038944
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0384249
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0382396
N4BP2L2 NEDD4 binding protein 2-like 2 0.0370767
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0368828
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0367822
PUM1 pumilio RNA-binding family member 1 0.0367696
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.036106
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0360543
SSBP2 single-stranded DNA binding protein 2 0.0360139
HDAC9 histone deacetylase 9 0.0359918
RPS3 ribosomal protein S3 0.0359765
ASXL1 additional sex combs like transcriptional regulator 1 0.0359538
ZSWIM5 zinc finger, SWIM-type containing 5 0.0356227
FBXL13 F-box and leucine-rich repeat protein 13 0.0353551
RPS23 ribosomal protein S23 0.0349283
PCBP2 poly(rC) binding protein 2 0.0347253
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0344284
ENO1 enolase 1, (alpha) 0.0343466
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0342783
BRD2 bromodomain containing 2 0.0340979
GRIK5 glutamate receptor, ionotropic, kainate 5 0.03359
RPS13 ribosomal protein S13 0.0335694
RPL30 ribosomal protein L30 0.0333688
RPL15 ribosomal protein L15 0.0330762
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0326599
DSTN destrin (actin depolymerizing factor) 0.032645
APLP2 amyloid beta (A4) precursor-like protein 2 0.032631
LRMDA leucine rich melanocyte differentiation associated 0.0325902
ANXA1 annexin A1 0.0322813
RPS17 ribosomal protein S17 0.0322013
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.032104
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.0319881
MYO6 myosin VI 0.0316121
RACK1 receptor for activated C kinase 1 0.0314758
MKRN1 makorin ring finger protein 1 0.031429
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0310582
ATM ATM serine/threonine kinase 0.0310286
CADPS2 Ca++-dependent secretion activator 2 0.0308839
GCLC glutamate-cysteine ligase, catalytic subunit 0.0303088
RPL12 ribosomal protein L12 0.0301541
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.030051
VIM vimentin 0.0296542
MTPN myotrophin 0.0296144
FNBP4 formin binding protein 4 0.0295803
MTDH metadherin 0.0293951
NSD3 nuclear receptor binding SET domain protein 3 0.0293663
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.029361
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0293446
CCSER1 coiled-coil serine-rich protein 1 0.0291759
RAD51B RAD51 paralog B 0.0290394
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0290301
NTN4 netrin 4 0.0289937
PHF3 PHD finger protein 3 0.028958
OXR1 oxidation resistance 1 0.0288868
GOLM2 golgi membrane protein 2 0.0288798
SDCBP syndecan binding protein (syntenin) 0.0288388
IFI16 interferon, gamma-inducible protein 16 0.0286868
LDHA lactate dehydrogenase A 0.0286808
MTCH1 mitochondrial carrier 1 0.0286363
ZCCHC8 zinc finger, CCHC domain containing 8 0.0286133
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0286017
RPL35 ribosomal protein L35 0.0285901
SRRM2 serine/arginine repetitive matrix 2 0.0285811
RO60 Ro60, Y RNA binding protein 0.0285747
ZSWIM6 zinc finger, SWIM-type containing 6 0.0285538
MBNL2 muscleblind-like splicing regulator 2 0.0285368
ATG7 autophagy related 7 0.0284634
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0283978
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0282477
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.028229
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0281489
TPR translocated promoter region, nuclear basket protein 0.028128
PNRC1 proline-rich nuclear receptor coactivator 1 0.0281169
ABHD5 abhydrolase domain containing 5 0.0280015
SND1 staphylococcal nuclease and tudor domain containing 1 0.0279215

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.219616
BACE2 beta-site APP-cleaving enzyme 2 -0.162851
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.152747
MACF1 microtubule-actin crosslinking factor 1 -0.121317
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.111187
LMO7 LIM domain 7 -0.107914
NDRG1 N-myc downstream regulated 1 -0.0915314
TMSB10 thymosin beta 10 -0.0885082
ESYT2 extended synaptotagmin-like protein 2 -0.0882442
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0870448
PTPRM protein tyrosine phosphatase, receptor type, M -0.0863842
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0832516
IGF2 insulin-like growth factor 2 -0.0828298
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0826895
STC1 stanniocalcin 1 -0.0812183
IGF1R insulin-like growth factor 1 receptor -0.0791583
MUC16 mucin 16, cell surface associated -0.0774679
IFIH1 interferon induced with helicase C domain 1 -0.0753704
LAMB3 laminin, beta 3 -0.075206
IGFBP3 insulin-like growth factor binding protein 3 -0.0744123
DLG1 discs, large homolog 1 (Drosophila) -0.073899
ANXA2 annexin A2 -0.0732322
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0718275
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0702061
CEMIP cell migration inducing protein, hyaluronan binding -0.0697367
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.067389
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0654485
MT2A metallothionein 2A -0.0641676
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0631195
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0626961
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0600923
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0596293
EGFR epidermal growth factor receptor -0.0571359
FBF1 Fas (TNFRSF6) binding factor 1 -0.0567104
ARHGAP26 Rho GTPase activating protein 26 -0.0564366
ERBIN erbb2 interacting protein -0.0563729
EFNA5 ephrin-A5 -0.0555309
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0549814
MYO1E myosin IE -0.0536873
OGA O-GlcNAcase -0.0520345
FNDC3B fibronectin type III domain containing 3B -0.0517445
BZW1 basic leucine zipper and W2 domains 1 -0.0501381
ANTXR2 anthrax toxin receptor 2 -0.0497283
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0489329
FBXO11 F-box protein 11 -0.0482401
F3 coagulation factor III (thromboplastin, tissue factor) -0.0480415
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0471988
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0465245
NF1 neurofibromin 1 -0.0453549
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0451786
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0448021
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0447048
TRA2A transformer 2 alpha homolog (Drosophila) -0.0446429
OSMR oncostatin M receptor -0.0441063
MYO5B myosin VB -0.0438695
LOC112694756 uncharaterized LOC112694756 -0.043351
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0431772
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0431595
SAMD4A sterile alpha motif domain containing 4A -0.0431544
SEPTIN2 septin 2 -0.0429612
KDM5B lysine (K)-specific demethylase 5B -0.0429179
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0425653
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0423185
SRPK2 SRSF protein kinase 2 -0.0421075
PARD3 par-3 family cell polarity regulator -0.0421061
AKAP13 A kinase (PRKA) anchor protein 13 -0.0420861
RNF149 ring finger protein 149 -0.0419673
NPC1 Niemann-Pick disease, type C1 -0.0412062
LOXL2 lysyl oxidase-like 2 -0.0409019
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0407515
NCOR2 nuclear receptor corepressor 2 -0.0407291
GSK3B glycogen synthase kinase 3 beta -0.0398196
LPP LIM domain containing preferred translocation partner in lipoma -0.0397052
NAP1L1 nucleosome assembly protein 1-like 1 -0.0390386
KDM7A lysine (K)-specific demethylase 7A -0.0384997
FOXO3 forkhead box O3 -0.03838
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0380514
JUP junction plakoglobin -0.0373098
KMT2C lysine (K)-specific methyltransferase 2C -0.0372893
ITPRID2 ITPR interacting domain containing 2 -0.0371949
RAB1A RAB1A, member RAS oncogene family -0.0363346
MXD1 MAX dimerization protein 1 -0.0363143
RAB10 RAB10, member RAS oncogene family -0.0360237
RAB8B RAB8B, member RAS oncogene family -0.0358811
C3 complement component 3 -0.0357996
TJP2 tight junction protein 2 -0.0357117
CD46 CD46 molecule, complement regulatory protein -0.0353135
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0352437
SPAG9 sperm associated antigen 9 -0.0350778
FOXO1 forkhead box O1 -0.0340761
B2M beta-2-microglobulin -0.0336081
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0335558
ARHGAP21 Rho GTPase activating protein 21 -0.0329793
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0328222
DLC1 DLC1 Rho GTPase activating protein -0.032699
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0326629
ATOSA atos homolog A -0.0325497
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0322013
PLAUR plasminogen activator, urokinase receptor -0.032135
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0319101