| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bimiralisib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bimiralisib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.10145 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0727415 |
| TXNRD1 | thioredoxin reductase 1 | 0.0671023 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0642728 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0636062 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0633937 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0608768 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.051803 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0514545 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0490182 |
| VCL | vinculin | 0.0450333 |
| BMP5 | bone morphogenetic protein 5 | 0.0438782 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0423614 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0391406 |
| SSH2 | slingshot protein phosphatase 2 | 0.038898 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0378556 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0377816 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.037728 |
| PDE10A | phosphodiesterase 10A | 0.0369375 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0364878 |
| MED13L | mediator complex subunit 13-like | 0.0363433 |
| RPS21 | ribosomal protein S21 | 0.0359778 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0344616 |
| CALD1 | caldesmon 1 | 0.032807 |
| DENND5B | DENN/MADD domain containing 5B | 0.0325563 |
| ADAR | adenosine deaminase, RNA-specific | 0.0321456 |
| RPL23 | ribosomal protein L23 | 0.0320442 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.031942 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0316752 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0309425 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0309213 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0303775 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0297268 |
| AEBP2 | AE binding protein 2 | 0.0296181 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0295513 |
| RNF145 | ring finger protein 145 | 0.0282967 |
| AHNAK | AHNAK nucleoprotein | 0.0280953 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0278684 |
| MRTFA | myocardin related transcription factor A | 0.0276322 |
| MACROD2 | MACRO domain containing 2 | 0.0274242 |
| DST | dystonin | 0.0273325 |
| KLF6 | Kruppel-like factor 6 | 0.0271336 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0267232 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0262791 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0261977 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0260636 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0259489 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0255967 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0255837 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.02517 |
| RPLP0 | ribosomal protein, large, P0 | 0.0242642 |
| MAP7 | microtubule-associated protein 7 | 0.0241377 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0240399 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0239598 |
| WWOX | WW domain containing oxidoreductase | 0.0232599 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0228962 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0226657 |
| TPI1 | triosephosphate isomerase 1 | 0.0224223 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0222669 |
| RPL11 | ribosomal protein L11 | 0.02217 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.0219457 |
| FOXP1 | forkhead box P1 | 0.0215771 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0211958 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0211827 |
| PMP22 | peripheral myelin protein 22 | 0.0211044 |
| RPS12 | ribosomal protein S12 | 0.0210375 |
| RPS15 | ribosomal protein S15 | 0.0206194 |
| B2M | beta-2-microglobulin | 0.0206155 |
| MYPN | myopalladin | 0.0201298 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0200332 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0199697 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0198829 |
| DSPP | dentin sialophosphoprotein | 0.0197914 |
| PHF3 | PHD finger protein 3 | 0.0195751 |
| HOMER1 | homer scaffolding protein 1 | 0.0192066 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0192003 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0186202 |
| MED13 | mediator complex subunit 13 | 0.0185623 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0183758 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0179927 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0177654 |
| TENM3 | teneurin transmembrane protein 3 | 0.0176312 |
| RPS8 | ribosomal protein S8 | 0.0174817 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0174484 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0174151 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0170619 |
| CEP112 | centrosomal protein 112kDa | 0.0169796 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0168704 |
| BPTF | bromodomain PHD finger transcription factor | 0.0167975 |
| TRIM37 | tripartite motif containing 37 | 0.0167339 |
| RPS25 | ribosomal protein S25 | 0.0166184 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0165321 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0160836 |
| PLCB4 | phospholipase C, beta 4 | 0.0160255 |
| CD2AP | CD2-associated protein | 0.0159469 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0159393 |
| RPS29 | ribosomal protein S29 | 0.0155879 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0155031 |
| RPL5 | ribosomal protein L5 | 0.0153699 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0153129 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.254668 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.120883 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.108616 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0987456 |
| EGR1 | early growth response 1 | -0.0947902 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0769361 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0757895 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0710754 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0680472 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.067261 |
| RAD51B | RAD51 paralog B | -0.0668625 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0661188 |
| COPA | coatomer protein complex, subunit alpha | -0.0635671 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0565391 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0564421 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0556275 |
| TPM3 | tropomyosin 3 | -0.0526096 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0521882 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0515533 |
| HMGA2 | high mobility group AT-hook 2 | -0.0491458 |
| MCL1 | myeloid cell leukemia 1 | -0.0477151 |
| POTEF | POTE ankyrin domain family, member F | -0.0462253 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0454643 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0447868 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0438109 |
| GOLGA4 | golgin A4 | -0.0419391 |
| CCNL1 | cyclin L1 | -0.0418245 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0405213 |
| BBX | bobby sox homolog (Drosophila) | -0.0398682 |
| ACTN1 | actinin, alpha 1 | -0.0388865 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0384541 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0381053 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0379548 |
| RAB7A | RAB7A, member RAS oncogene family | -0.03792 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0377582 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0375667 |
| NUP58 | nucleoporin 58 | -0.0372121 |
| FMNL2 | formin-like 2 | -0.0369266 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0360169 |
| PTK2 | protein tyrosine kinase 2 | -0.0358964 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0356936 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0353987 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0353006 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0345408 |
| RSF1 | remodeling and spacing factor 1 | -0.034266 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0336849 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0333634 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0333414 |
| EGFR | epidermal growth factor receptor | -0.0328815 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0326269 |
| PRKCE | protein kinase C, epsilon | -0.0322653 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.032174 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0321585 |
| MORF4L2 | mortality factor 4 like 2 | -0.0319786 |
| RBM25 | RNA binding motif protein 25 | -0.0316359 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0311646 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0310207 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0309563 |
| YBX1 | Y box binding protein 1 | -0.0308659 |
| PFN1 | profilin 1 | -0.0306795 |
| WDR45B | WD repeat domain 45B | -0.0304313 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0302272 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0302157 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0300226 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | -0.0300115 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0299721 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0298146 |
| ARF4 | ADP-ribosylation factor 4 | -0.0296739 |
| PKM | pyruvate kinase, muscle | -0.0296613 |
| PYGL | phosphorylase, glycogen, liver | -0.0296592 |
| MMP12 | matrix metallopeptidase 12 | -0.0294012 |
| RYR3 | ryanodine receptor 3 | -0.0293611 |
| SRP54 | signal recognition particle 54kDa | -0.0293583 |
| TPM2 | tropomyosin 2 (beta) | -0.0286788 |
| HELZ | helicase with zinc finger | -0.0282883 |
| PHIP | pleckstrin homology domain interacting protein | -0.0281159 |
| SRPK1 | SRSF protein kinase 1 | -0.0279875 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0279195 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0275906 |
| TMEM165 | transmembrane protein 165 | -0.0275454 |
| STC1 | stanniocalcin 1 | -0.0274969 |
| HM13 | histocompatibility (minor) 13 | -0.0270338 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0269052 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0266942 |
| NF1 | neurofibromin 1 | -0.0266187 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0263726 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0263493 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0261109 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0260809 |
| HYOU1 | hypoxia up-regulated 1 | -0.0258859 |
| ZNF292 | zinc finger protein 292 | -0.0257742 |
| HDGF | hepatoma-derived growth factor | -0.0255741 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0255706 |
| NBAS | neuroblastoma amplified sequence | -0.0254637 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0252507 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0252126 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0251361 |
| CALR | calreticulin | -0.0251036 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0250175 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0249955 |
