Bimiralisib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.162037
PABPC1 poly(A) binding protein, cytoplasmic 1 0.101011
FBXO32 F-box protein 32 0.099361
FTL ferritin, light polypeptide 0.098625
EXT1 exostosin glycosyltransferase 1 0.0903524
IFI27 interferon, alpha-inducible protein 27 0.0901392
RPS23 ribosomal protein S23 0.0896806
RPS12 ribosomal protein S12 0.0891266
RPLP2 ribosomal protein, large, P2 0.0879265
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0870052
RPS8 ribosomal protein S8 0.0857285
RPS3 ribosomal protein S3 0.0846763
RPS6 ribosomal protein S6 0.080963
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0803791
ALCAM activated leukocyte cell adhesion molecule 0.0803528
IFI6 interferon, alpha-inducible protein 6 0.0802407
TXNIP thioredoxin interacting protein 0.0784002
RPS29 ribosomal protein S29 0.0736518
ISG15 ISG15 ubiquitin-like modifier 0.0730236
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0714472
RPS19 ribosomal protein S19 0.0708691
EIF1 eukaryotic translation initiation factor 1 0.0701005
ZSWIM6 zinc finger, SWIM-type containing 6 0.0700862
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0693804
RPL37A ribosomal protein L37a 0.0686213
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0661855
GOLGA4 golgin A4 0.0642556
SOX4 SRY (sex determining region Y)-box 4 0.0609063
RPL23 ribosomal protein L23 0.0608348
RPS25 ribosomal protein S25 0.0592417
GOLGB1 golgin B1 0.0580047
RPL9 ribosomal protein L9 0.0560072
RPS17 ribosomal protein S17 0.0557161
RACK1 receptor for activated C kinase 1 0.055191
RPS13 ribosomal protein S13 0.0533994
PRRC2C proline-rich coiled-coil 2C 0.0523034
DSPP dentin sialophosphoprotein 0.0511764
RPS2 ribosomal protein S2 0.0504912
IFITM3 interferon induced transmembrane protein 3 0.0501949
RPL8 ribosomal protein L8 0.0499198
RPS27 ribosomal protein S27 0.0472787
VMP1 vacuole membrane protein 1 0.0466834
RPL5 ribosomal protein L5 0.0453278
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.044451
STAT1 signal transducer and activator of transcription 1, 91kDa 0.044305
RPS27A ribosomal protein S27a 0.0442471
RPL37 ribosomal protein L37 0.0442107
IFI16 interferon, gamma-inducible protein 16 0.0441484
RPL12 ribosomal protein L12 0.0440334
AKAP9 A kinase (PRKA) anchor protein 9 0.0438032
RPS10 ribosomal protein S10 0.043381
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0433209
SQSTM1 sequestosome 1 0.0425756
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0424777
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0424543
WSB1 WD repeat and SOCS box containing 1 0.0422346
IFITM1 interferon induced transmembrane protein 1 0.0420409
RPL32 ribosomal protein L32 0.0419357
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0412471
VIM vimentin 0.0410641
ENO1 enolase 1, (alpha) 0.0404951
RPL31 ribosomal protein L31 0.0400558
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0397481
FHIT fragile histidine triad 0.0394471
RPS14 ribosomal protein S14 0.0389899
IFIH1 interferon induced with helicase C domain 1 0.0389243
RPL7A ribosomal protein L7a 0.0389086
KTN1 kinectin 1 (kinesin receptor) 0.0378313
RPLP1 ribosomal protein, large, P1 0.0378012
PALLD palladin, cytoskeletal associated protein 0.0376413
RAD51B RAD51 paralog B 0.0375973
MGST1 microsomal glutathione S-transferase 1 0.0375041
TMF1 TATA element modulatory factor 1 0.0374675
RPL19 ribosomal protein L19 0.0374263
RPL11 ribosomal protein L11 0.0370916
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0370223
RPL36 ribosomal protein L36 0.0367808
MDK midkine (neurite growth-promoting factor 2) 0.0365616
CEP350 centrosomal protein 350kDa 0.0364821
CSNK1A1 casein kinase 1, alpha 1 0.0356334
GPHN gephyrin 0.0353917
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0353041
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0352429
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0352083
ANKRD12 ankyrin repeat domain 12 0.035094
RPL15 ribosomal protein L15 0.0348594
RPL7 ribosomal protein L7 0.0347203
MX1 MX dynamin-like GTPase 1 0.0344688
RPS15 ribosomal protein S15 0.034235
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0338855
ARHGAP42 Rho GTPase activating protein 42 0.033862
BBX bobby sox homolog (Drosophila) 0.033616
ADAR adenosine deaminase, RNA-specific 0.0333363
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0332331
HLA-B major histocompatibility complex, class I, B 0.0328108
RHOBTB3 Rho-related BTB domain containing 3 0.03263
RPS11 ribosomal protein S11 0.0325282
BRD2 bromodomain containing 2 0.0323742
VCL vinculin 0.0322611
RPL21 ribosomal protein L21 0.0322542

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.128504
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122155
GRB10 growth factor receptor-bound protein 10 -0.121321
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0914435
CCND1 cyclin D1 -0.0826209
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0671003
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0648132
FN1 fibronectin 1 -0.0636472
TSC22D2 TSC22 domain family, member 2 -0.0626875
NAMPT nicotinamide phosphoribosyltransferase -0.0591647
LAMC2 laminin, gamma 2 -0.0568215
ANXA2 annexin A2 -0.0554678
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0542968
TMSB4X thymosin beta 4, X-linked -0.0541663
ADAM9 ADAM metallopeptidase domain 9 -0.0535881
MARCHF6 membrane associated ring-CH-type finger 6 -0.0516462
RAD21 RAD21 homolog (S. pombe) -0.0501384
TOP1 topoisomerase (DNA) I -0.0465394
TM4SF1 transmembrane 4 L six family member 1 -0.0454
TFG TRK-fused gene -0.0412994
LMO7 LIM domain 7 -0.0410572
PTK2 protein tyrosine kinase 2 -0.040708
HMGA1 high mobility group AT-hook 1 -0.0392159
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0379486
IRF6 interferon regulatory factor 6 -0.0376337
PLAU plasminogen activator, urokinase -0.037588
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0374868
PLEC plectin -0.0372689
FNDC3B fibronectin type III domain containing 3B -0.0372225
F3 coagulation factor III (thromboplastin, tissue factor) -0.0348174
S100A6 S100 calcium binding protein A6 -0.0343819
USP3 ubiquitin specific peptidase 3 -0.0337801
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0336224
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0324202
ZFAND3 zinc finger, AN1-type domain 3 -0.0322584
BHLHE40 basic helix-loop-helix family, member e40 -0.0318884
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0314468
KDM3A lysine (K)-specific demethylase 3A -0.0314288
FAM3C family with sequence similarity 3, member C -0.0311727
LOC112694756 uncharaterized LOC112694756 -0.0311202
NPEPPS aminopeptidase puromycin sensitive -0.0309317
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0308311
ARF1 ADP-ribosylation factor 1 -0.030777
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0304372
PGK1 phosphoglycerate kinase 1 -0.0300362
COPA coatomer protein complex, subunit alpha -0.0287984
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0278865
G0S2 G0/G1 switch 2 -0.0278428
POTEF POTE ankyrin domain family, member F -0.0275171
GARS1 glycyl-tRNA synthetase 1 -0.0275167
RLF rearranged L-myc fusion -0.0273063
SDC4 syndecan 4 -0.0269961
TMEM123 transmembrane protein 123 -0.0268295
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0267044
OSBPL3 oxysterol binding protein-like 3 -0.0264393
F11R F11 receptor -0.0262839
CYRIB CYFIP related Rac1 interactor B -0.0258612
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0256733
KDM5B lysine (K)-specific demethylase 5B -0.0251718
LMAN1 lectin, mannose-binding, 1 -0.0250493
RCOR1 REST corepressor 1 -0.0246034
MSMO1 methylsterol monooxygenase 1 -0.0245264
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0245198
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0244455
CDC73 cell division cycle 73 -0.024279
GNAS GNAS complex locus -0.0241849
MXD1 MAX dimerization protein 1 -0.0240355
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0239652
ITCH itchy E3 ubiquitin protein ligase -0.0237994
CRABP2 cellular retinoic acid binding protein 2 -0.0236456
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0235227
LAMB3 laminin, beta 3 -0.0232746
FLNA filamin A, alpha -0.0231079
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0230995
FOSL1 FOS-like antigen 1 -0.0229328
APP amyloid beta (A4) precursor protein -0.0228846
AREG amphiregulin -0.022725
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0221411
KRT8 keratin 8, type II -0.0221364
STRN3 striatin, calmodulin binding protein 3 -0.02207
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.021954
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0217626
TMSB10 thymosin beta 10 -0.0217084
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0216259
ACTN4 actinin, alpha 4 -0.0215942
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0213333
MSI2 musashi RNA-binding protein 2 -0.0212618
CDK17 cyclin-dependent kinase 17 -0.0212383
NUP58 nucleoporin 58 -0.0212133
ACTG1 actin gamma 1 -0.020898
TP53BP2 tumor protein p53 binding protein 2 -0.0205042
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.020487
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0204821
S100A10 S100 calcium binding protein A10 -0.0203461
PKM pyruvate kinase, muscle -0.0203355
NT5E 5'-nucleotidase, ecto (CD73) -0.0203086
ELL2 elongation factor, RNA polymerase II, 2 -0.0201839
PPARD peroxisome proliferator-activated receptor delta -0.0201311
IQGAP1 IQ motif containing GTPase activating protein 1 -0.020043
ETV5 ets variant 5 -0.0197712