Bimiralisib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bimiralisib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 0.134278
COL8A1 collagen, type VIII, alpha 1 0.122464
RPS6 ribosomal protein S6 0.110688
AGTPBP1 ATP/GTP binding protein 1 0.106973
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.104842
PM20D1 peptidase M20 domain containing 1 0.101523
KYNU kynureninase 0.0951575
DST dystonin 0.0886271
PDLIM5 PDZ and LIM domain 5 0.0833372
RPS12 ribosomal protein S12 0.0832608
RPS8 ribosomal protein S8 0.0702774
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0661564
RPL37A ribosomal protein L37a 0.0618452
RPS23 ribosomal protein S23 0.060385
P3H2 prolyl 3-hydroxylase 2 0.0592685
MAP7 microtubule-associated protein 7 0.0573488
SAMD4A sterile alpha motif domain containing 4A 0.0546046
EXT1 exostosin glycosyltransferase 1 0.0545644
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0534977
LGALS3 lectin, galactoside-binding, soluble, 3 0.0514599
RPS3 ribosomal protein S3 0.0498253
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0460416
NTN4 netrin 4 0.0450366
VIM vimentin 0.0444375
RPS2 ribosomal protein S2 0.0441505
XYLT1 xylosyltransferase I 0.0438961
NFX1 nuclear transcription factor, X-box binding 1 0.0429836
CLU clusterin 0.0418069
RPS17 ribosomal protein S17 0.0409061
ASTN2 astrotactin 2 0.0404635
ZEB2 zinc finger E-box binding homeobox 2 0.0401418
RPL31 ribosomal protein L31 0.0401414
RACK1 receptor for activated C kinase 1 0.0396846
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0394125
RPS27 ribosomal protein S27 0.0389733
RPL21 ribosomal protein L21 0.0388618
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0382463
BASP1 brain abundant, membrane attached signal protein 1 0.0370587
PCDH15 protocadherin-related 15 0.036959
PTEN phosphatase and tensin homolog 0.0368801
RPS25 ribosomal protein S25 0.0362789
SMAD2 SMAD family member 2 0.0362677
FTL ferritin, light polypeptide 0.0359613
PCBP2 poly(rC) binding protein 2 0.0359316
RPL26 ribosomal protein L26 0.0353014
RPL7A ribosomal protein L7a 0.034827
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0342726
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0336211
LSAMP limbic system-associated membrane protein 0.0336091
PALLD palladin, cytoskeletal associated protein 0.0330495
SQSTM1 sequestosome 1 0.032298
ATXN1 ataxin 1 0.0318423
RPS19 ribosomal protein S19 0.0308328
RPL5 ribosomal protein L5 0.0307592
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0305282
RPL9 ribosomal protein L9 0.028891
MYPN myopalladin 0.0288885
ZSWIM6 zinc finger, SWIM-type containing 6 0.02827
MGST1 microsomal glutathione S-transferase 1 0.0282538
OLFML2A olfactomedin-like 2A 0.0281968
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0281042
RPLP2 ribosomal protein, large, P2 0.0279894
CHL1 cell adhesion molecule L1-like 0.0276783
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0275994
CTIF CBP80/20-dependent translation initiation factor 0.027403
RPL36 ribosomal protein L36 0.0270954
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0270571
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.027044
RPS13 ribosomal protein S13 0.0270271
SMOC1 SPARC related modular calcium binding 1 0.0266773
CHSY3 chondroitin sulfate synthase 3 0.0266543
ANTXR1 anthrax toxin receptor 1 0.026627
RPS14 ribosomal protein S14 0.0265365
RPS29 ribosomal protein S29 0.0259026
PDE4D phosphodiesterase 4D, cAMP-specific 0.0254224
OXSR1 oxidative stress responsive 1 0.0253533
RPL12 ribosomal protein L12 0.0251176
RPL36A ribosomal protein L36a 0.0249724
NEK7 NIMA-related kinase 7 0.0248895
MFSD12 major facilitator superfamily domain containing 12 0.024758
RHOA ras homolog family member A 0.0246233
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0242192
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0241974
IL6 interleukin 6 0.0241766
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.023601
CLIP1 CAP-GLY domain containing linker protein 1 0.0234745
CUX1 cut-like homeobox 1 0.0233962
TXNIP thioredoxin interacting protein 0.0230572
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0228108
RPL11 ribosomal protein L11 0.0227532
INTS6 integrator complex subunit 6 0.022655
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0223325
GLCCI1 glucocorticoid induced 1 0.0220488
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0218864
DGKD diacylglycerol kinase, delta 130kDa 0.0213161
SRRM2 serine/arginine repetitive matrix 2 0.0212063
ABLIM1 actin binding LIM protein 1 0.0211727
GOLGB1 golgin B1 0.0209541
RPS11 ribosomal protein S11 0.0207843
RPS7 ribosomal protein S7 0.0205781

decreased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 -0.208388
FN1 fibronectin 1 -0.184398
NAMPT nicotinamide phosphoribosyltransferase -0.168715
NRCAM neuronal cell adhesion molecule -0.110316
TFPI2 tissue factor pathway inhibitor 2 -0.0979188
NPAS2 neuronal PAS domain protein 2 -0.0913269
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0898049
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0894926
TMSB10 thymosin beta 10 -0.0889561
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0798048
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0776091
PCBP3 poly(rC) binding protein 3 -0.0775043
GDA guanine deaminase -0.0748653
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0743097
GRAMD1B GRAM domain containing 1B -0.0733569
PSD3 pleckstrin and Sec7 domain containing 3 -0.0699697
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0669609
TM4SF1 transmembrane 4 L six family member 1 -0.0668989
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0631956
ASPH aspartate beta-hydroxylase -0.0608138
PTMA prothymosin, alpha -0.0591731
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0566323
TXNRD1 thioredoxin reductase 1 -0.0553371
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0501905
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0477298
RGS2 regulator of G-protein signaling 2 -0.0455808
DOCK4 dedicator of cytokinesis 4 -0.0447248
STC1 stanniocalcin 1 -0.0442695
PYGL phosphorylase, glycogen, liver -0.0434563
CDH13 cadherin 13 -0.0399868
MAML3 mastermind-like 3 (Drosophila) -0.0393907
OGA O-GlcNAcase -0.0392345
RTN1 reticulon 1 -0.0383335
SRGN serglycin -0.0382674
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.03787
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0376701
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0376582
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0361662
NCOA7 nuclear receptor coactivator 7 -0.0360118
BMERB1 bMERB domain containing 1 -0.0358829
PTGR1 prostaglandin reductase 1 -0.0358657
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0353724
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0351085
MCL1 myeloid cell leukemia 1 -0.0344111
PGK1 phosphoglycerate kinase 1 -0.033871
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0329755
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0327591
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0326356
NALF1 NALCN channel auxiliary factor 1 -0.0325483
RTN4 reticulon 4 -0.03168
CTSL cathepsin L -0.0307482
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0306916
KDM3A lysine (K)-specific demethylase 3A -0.0303898
LMAN1 lectin, mannose-binding, 1 -0.0299795
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0294336
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0294248
KPNB1 karyopherin (importin) beta 1 -0.0291379
TMSB4X thymosin beta 4, X-linked -0.0291009
GNAS GNAS complex locus -0.0289801
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0283055
ZMYND8 zinc finger, MYND-type containing 8 -0.0282687
BRWD3 bromodomain and WD repeat domain containing 3 -0.027605
ELL2 elongation factor, RNA polymerase II, 2 -0.0275442
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0272486
GLIS3 GLIS family zinc finger 3 -0.0268167
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0267345
IER3 immediate early response 3 -0.0267194
LOC112694756 uncharaterized LOC112694756 -0.0264707
MT2A metallothionein 2A -0.026112
PDGFA platelet-derived growth factor alpha polypeptide -0.0260972
CANX calnexin -0.026
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0256646
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0253265
OSMR oncostatin M receptor -0.0251384
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0250468
COL4A5 collagen, type IV, alpha 5 -0.0246831
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0246537
BZW1 basic leucine zipper and W2 domains 1 -0.0241594
WDFY2 WD repeat and FYVE domain containing 2 -0.0240479
IGFBP3 insulin-like growth factor binding protein 3 -0.0240385
CUL4B cullin 4B -0.0238925
BLTP2 bridge-like lipid transfer protein family member 2 -0.0235183
VDAC1 voltage-dependent anion channel 1 -0.0234557
RPLP1 ribosomal protein, large, P1 -0.0232646
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0231777
TNPO1 transportin 1 -0.0231625
CDK17 cyclin-dependent kinase 17 -0.023119
NT5E 5'-nucleotidase, ecto (CD73) -0.023033
CCDC68 coiled-coil domain containing 68 -0.0229273
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0228673
SEPTIN10 septin 10 -0.022844
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0228312
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0227731
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0225511
RPH3AL rabphilin 3A-like (without C2 domains) -0.0222339
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0221974
MATR3 matrin 3 -0.0220426
RPL35A ribosomal protein L35a -0.0220056
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0219985
WDR45B WD repeat domain 45B -0.0218796