Bimiralisib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

110 genes differentially expressed following the Bimiralisib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.176411
TPT1 tumor protein, translationally-controlled 1 0.160354
RPS6 ribosomal protein S6 0.151665
RPL37 ribosomal protein L37 0.143526
EXT1 exostosin glycosyltransferase 1 0.142005
BRD2 bromodomain containing 2 0.133233
MT2A metallothionein 2A 0.128184
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.123188
RPL37A ribosomal protein L37a 0.112505
RPL7 ribosomal protein L7 0.111066
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.101413
RPS23 ribosomal protein S23 0.099305
SOX4 SRY (sex determining region Y)-box 4 0.0981934
RPL31 ribosomal protein L31 0.0955174
RPS21 ribosomal protein S21 0.0924678
RPL23 ribosomal protein L23 0.0867315
AKAP12 A kinase (PRKA) anchor protein 12 0.0822007
RPL5 ribosomal protein L5 0.0816825
PTMA prothymosin, alpha 0.0754899
DST dystonin 0.0748547
ANKRD17 ankyrin repeat domain 17 0.0718347
FTL ferritin, light polypeptide 0.0651366
RPLP0 ribosomal protein, large, P0 0.0581305
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0561176
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0549274
RPS24 ribosomal protein S24 0.0538304
SLC38A1 solute carrier family 38, member 1 0.0524037
SAMD4A sterile alpha motif domain containing 4A 0.0508764
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0476418
NDRG1 N-myc downstream regulated 1 0.0463542
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0454588
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0429562
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0421494
YAP1 Yes-associated protein 1 0.0376913
RPS19 ribosomal protein S19 0.0360519
WSB1 WD repeat and SOCS box containing 1 0.0330546
TAS2R14 taste receptor, type 2, member 14 0.0310655
NAP1L1 nucleosome assembly protein 1-like 1 0.0307062
STC1 stanniocalcin 1 0.02813
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.024786
TRIO trio Rho guanine nucleotide exchange factor 0.0238444
KMT2C lysine (K)-specific methyltransferase 2C 0.0236109
ACTG1 actin gamma 1 0.0199563
LIMS1 LIM and senescent cell antigen-like domains 1 0.0131784
PRRC2C proline-rich coiled-coil 2C 0.0125087
JMJD1C jumonji domain containing 1C 0.0105911
CD44 CD44 molecule (Indian blood group) 0.00926275
RACK1 receptor for activated C kinase 1 0.00785712
EFNA5 ephrin-A5 0.00740677
LDHA lactate dehydrogenase A 0.00555691
VCL vinculin 0.00428064
PSD3 pleckstrin and Sec7 domain containing 3 0.00347852
INHBA inhibin, beta A 0.00327991
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00243291

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.139518
PDE10A phosphodiesterase 10A -0.138985
PKM pyruvate kinase, muscle -0.133124
OSMR oncostatin M receptor -0.122611
AHNAK AHNAK nucleoprotein -0.119569
RPL11 ribosomal protein L11 -0.11569
CCNI cyclin I -0.113904
PDE4D phosphodiesterase 4D, cAMP-specific -0.112617
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.11095
CDH13 cadherin 13 -0.0990723
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0984952
PRELID2 PRELI domain containing 2 -0.0971946
TMSB10 thymosin beta 10 -0.0965447
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.096175
NF1 neurofibromin 1 -0.0918109
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0893923
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0831585
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0829345
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0808709
MAP1B microtubule-associated protein 1B -0.0806909
ASPH aspartate beta-hydroxylase -0.0796407
FN1 fibronectin 1 -0.0699231
MYOF myoferlin -0.0639198
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0635808
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.061814
ZBTB20 zinc finger and BTB domain containing 20 -0.0608227
ESYT2 extended synaptotagmin-like protein 2 -0.0602872
MAML3 mastermind-like 3 (Drosophila) -0.0599838
NAV1 neuron navigator 1 -0.0584544
NALF1 NALCN channel auxiliary factor 1 -0.0559986
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0547174
MAP4 microtubule-associated protein 4 -0.0537386
MYO1E myosin IE -0.0493362
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.049236
RPS8 ribosomal protein S8 -0.0466646
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0432068
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0368103
HMGA2 high mobility group AT-hook 2 -0.0364236
IGFBP3 insulin-like growth factor binding protein 3 -0.0359075
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0335195
ENO1 enolase 1, (alpha) -0.0309285
COL6A1 collagen, type VI, alpha 1 -0.029453
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0286606
PGK1 phosphoglycerate kinase 1 -0.0264738
THSD4 thrombospondin, type I, domain containing 4 -0.0248877
COL6A3 collagen, type VI, alpha 3 -0.0244462
FNDC3B fibronectin type III domain containing 3B -0.0234704
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.021728
EGFR epidermal growth factor receptor -0.0159205
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0146057
B2M beta-2-microglobulin -0.0138976
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0123366
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00520232
VIM vimentin -0.00208183
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.00184001
MED13L mediator complex subunit 13-like -7.96819E-4