| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bimiralisib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bimiralisib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | 0.119248 |
| MT2A | metallothionein 2A | 0.116121 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0968876 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0783983 |
| RND3 | Rho family GTPase 3 | 0.0713509 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0653906 |
| VMP1 | vacuole membrane protein 1 | 0.0647125 |
| RPS12 | ribosomal protein S12 | 0.0603526 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0599875 |
| KYNU | kynureninase | 0.0594032 |
| VEGFA | vascular endothelial growth factor A | 0.0523718 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0522656 |
| GOLGB1 | golgin B1 | 0.050813 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.048566 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0448689 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.043083 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0420293 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0415055 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0361844 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0361618 |
| SQSTM1 | sequestosome 1 | 0.0360579 |
| TXNIP | thioredoxin interacting protein | 0.0359683 |
| RPS2 | ribosomal protein S2 | 0.0352237 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0352055 |
| SP100 | SP100 nuclear antigen | 0.03393 |
| AHR | aryl hydrocarbon receptor | 0.0333079 |
| BPTF | bromodomain PHD finger transcription factor | 0.0332736 |
| STC1 | stanniocalcin 1 | 0.0324915 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0316931 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0309721 |
| ARFGEF3 | ARFGEF family member 3 | 0.0304342 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0301937 |
| JMJD1C | jumonji domain containing 1C | 0.0297355 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0290626 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0282125 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0281407 |
| INTS6 | integrator complex subunit 6 | 0.0277602 |
| PMP22 | peripheral myelin protein 22 | 0.0272754 |
| OPTN | optineurin | 0.0272092 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0267298 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0264824 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0264655 |
| RPL21 | ribosomal protein L21 | 0.026456 |
| MSN | moesin | 0.0262639 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0262347 |
| RIGI | RNA sensor RIG-I | 0.0259606 |
| RPS23 | ribosomal protein S23 | 0.0257972 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0256088 |
| RPL37A | ribosomal protein L37a | 0.0255906 |
| RPS3 | ribosomal protein S3 | 0.0252164 |
| USP53 | ubiquitin specific peptidase 53 | 0.0249074 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0248409 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0248097 |
| TMF1 | TATA element modulatory factor 1 | 0.024529 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0241985 |
| RPL5 | ribosomal protein L5 | 0.0241079 |
| ATXN1 | ataxin 1 | 0.0233821 |
| RPS8 | ribosomal protein S8 | 0.023234 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0223468 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0219984 |
| PLSCR1 | phospholipid scramblase 1 | 0.0218551 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0216118 |
| CD44 | CD44 molecule (Indian blood group) | 0.0215066 |
| BRD2 | bromodomain containing 2 | 0.0214621 |
| MT1E | metallothionein 1E | 0.0210727 |
| MYO9A | myosin IXA | 0.0208569 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0206785 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0202787 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | 0.0200161 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0198382 |
| B2M | beta-2-microglobulin | 0.0196503 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0195913 |
| PGM3 | phosphoglucomutase 3 | 0.0195446 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0195063 |
| DUSP10 | dual specificity phosphatase 10 | 0.0194363 |
| RPL23 | ribosomal protein L23 | 0.0191563 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.019033 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0189544 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0188844 |
| RACK1 | receptor for activated C kinase 1 | 0.018734 |
| HMGA2 | high mobility group AT-hook 2 | 0.0186664 |
| PHF3 | PHD finger protein 3 | 0.0185937 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0182853 |
| RPS25 | ribosomal protein S25 | 0.0182389 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0180105 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0179153 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0178277 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0177672 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0176766 |
| FAM3C | family with sequence similarity 3, member C | 0.0176741 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.017624 |
| RPLP2 | ribosomal protein, large, P2 | 0.0175025 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0172257 |
| SH3BP4 | SH3-domain binding protein 4 | 0.0170641 |
| EXOC4 | exocyst complex component 4 | 0.01703 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0167083 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0167054 |
| UBN2 | ubinuclein 2 | 0.0166941 |
| ATF4 | activating transcription factor 4 | 0.016601 |
| RPS10 | ribosomal protein S10 | 0.0165634 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | -0.227947 |
| FN1 | fibronectin 1 | -0.203196 |
| FRMD4A | FERM domain containing 4A | -0.174485 |
| VIM | vimentin | -0.167543 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.131128 |
| COL6A3 | collagen, type VI, alpha 3 | -0.121951 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.102581 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0998987 |
| PGK1 | phosphoglycerate kinase 1 | -0.0998032 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0929376 |
| IER3 | immediate early response 3 | -0.0874682 |
| CADM1 | cell adhesion molecule 1 | -0.0850126 |
| EGR1 | early growth response 1 | -0.0840919 |
| DST | dystonin | -0.0777677 |
| PDE10A | phosphodiesterase 10A | -0.0750875 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0737202 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0727242 |
| VCAN | versican | -0.0724976 |
| TPM4 | tropomyosin 4 | -0.0700355 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.067096 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0635359 |
| THBS1 | thrombospondin 1 | -0.0609856 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0605683 |
| ANXA2 | annexin A2 | -0.0563019 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0550714 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0550342 |
| PTMA | prothymosin, alpha | -0.0536797 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0533528 |
| TMSB4X | thymosin beta 4, X-linked | -0.0530217 |
| ATP13A3 | ATPase type 13A3 | -0.0521299 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0514676 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.050432 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0486832 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0473474 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0469618 |
| RTN4 | reticulon 4 | -0.0461657 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0459411 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0456541 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0446487 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0441446 |
| ACTG1 | actin gamma 1 | -0.0435512 |
| ZNF292 | zinc finger protein 292 | -0.0431029 |
| TMSB10 | thymosin beta 10 | -0.0426838 |
| COL5A1 | collagen, type V, alpha 1 | -0.0426331 |
| GNAS | GNAS complex locus | -0.042459 |
| RAI14 | retinoic acid induced 14 | -0.0423886 |
| TMEM123 | transmembrane protein 123 | -0.0423655 |
| ANLN | anillin, actin binding protein | -0.0423608 |
| QKI | QKI, KH domain containing, RNA binding | -0.0423337 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0407193 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0403318 |
| CTSD | cathepsin D | -0.0402417 |
| COL1A1 | collagen, type I, alpha 1 | -0.0401683 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0401365 |
| COL1A2 | collagen, type I, alpha 2 | -0.040075 |
| TUBB | tubulin, beta class I | -0.0397214 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0394718 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0393861 |
| GLIS3 | GLIS family zinc finger 3 | -0.0388779 |
| FTL | ferritin, light polypeptide | -0.0387348 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0386443 |
| TKT | transketolase | -0.038361 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.037679 |
| TENM2 | teneurin transmembrane protein 2 | -0.0373959 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0369568 |
| THBS2 | thrombospondin 2 | -0.036844 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0367295 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0365992 |
| PKM | pyruvate kinase, muscle | -0.0365962 |
| AHNAK | AHNAK nucleoprotein | -0.0365931 |
| HELZ | helicase with zinc finger | -0.0363982 |
| TXNRD1 | thioredoxin reductase 1 | -0.0361668 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0360068 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0351444 |
| FLNA | filamin A, alpha | -0.0350336 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0348935 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0347622 |
| TPM1 | tropomyosin 1 (alpha) | -0.034415 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.034415 |
| CALR | calreticulin | -0.0343869 |
| STAG2 | stromal antigen 2 | -0.0340328 |
| RPS24 | ribosomal protein S24 | -0.0336933 |
| VCL | vinculin | -0.0336901 |
| BNC2 | basonuclin 2 | -0.0333866 |
| CUL4B | cullin 4B | -0.0333561 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0329381 |
| WDR45B | WD repeat domain 45B | -0.0328842 |
| POTEF | POTE ankyrin domain family, member F | -0.032742 |
| NAV1 | neuron navigator 1 | -0.0325875 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0324676 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0319744 |
| SPAG9 | sperm associated antigen 9 | -0.0314179 |
| LDHA | lactate dehydrogenase A | -0.0312643 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0310638 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0307429 |
| RBM39 | RNA binding motif protein 39 | -0.0303377 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0299433 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.029746 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0296526 |
| CTSB | cathepsin B | -0.0295405 |
