Bimiralisib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bimiralisib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bimiralisib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.176703
TIMP3 TIMP metallopeptidase inhibitor 3 0.127549
MT2A metallothionein 2A 0.117379
B2M beta-2-microglobulin 0.0859817
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.08221
KYNU kynureninase 0.0800973
ZSWIM6 zinc finger, SWIM-type containing 6 0.0787509
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0783543
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0741352
IL6 interleukin 6 0.0730359
GOLGB1 golgin B1 0.0677108
PDLIM5 PDZ and LIM domain 5 0.0656664
RPS8 ribosomal protein S8 0.0555141
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0524198
FNIP1 folliculin interacting protein 1 0.0493626
RND3 Rho family GTPase 3 0.0489485
EXT1 exostosin glycosyltransferase 1 0.0482935
ZBTB20 zinc finger and BTB domain containing 20 0.0480702
INTS6 integrator complex subunit 6 0.0463062
HDAC9 histone deacetylase 9 0.0460395
RAD51B RAD51 paralog B 0.045693
DSTN destrin (actin depolymerizing factor) 0.0452943
VIM vimentin 0.0442782
AKAP12 A kinase (PRKA) anchor protein 12 0.0422899
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0412914
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0412729
ENO1 enolase 1, (alpha) 0.0407222
TTC3 tetratricopeptide repeat domain 3 0.0396711
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0391728
FN1 fibronectin 1 0.0383839
HIP1 huntingtin interacting protein 1 0.03813
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0362938
IGFBP7 insulin-like growth factor binding protein 7 0.0356732
SAMD4A sterile alpha motif domain containing 4A 0.0353143
ACTG1 actin gamma 1 0.0353015
CUX1 cut-like homeobox 1 0.0348912
PDIA6 protein disulfide isomerase family A, member 6 0.0345156
EGFR epidermal growth factor receptor 0.0343371
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0342482
MYADM myeloid-associated differentiation marker 0.0335469
PTGES2 prostaglandin E synthase 2 0.0333852
FTL ferritin, light polypeptide 0.033173
TMEM165 transmembrane protein 165 0.0331346
TNS3 tensin 3 0.0328187
LIMS1 LIM and senescent cell antigen-like domains 1 0.0327287
GPBP1 GC-rich promoter binding protein 1 0.0326277
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0323957
NFE2L2 nuclear factor, erythroid 2-like 2 0.0320804
JMJD1C jumonji domain containing 1C 0.0320354
HLA-A major histocompatibility complex, class I, A 0.0310903
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0306673
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0306007
MYLK myosin light chain kinase 0.0301961
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0298991
RPL37A ribosomal protein L37a 0.0298203
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0296646
RPS23 ribosomal protein S23 0.0294188
RPL12 ribosomal protein L12 0.0290927
YIPF5 Yip1 domain family, member 5 0.0290519
BCAS3 breast carcinoma amplified sequence 3 0.0284678
MBNL2 muscleblind-like splicing regulator 2 0.0284282
NCOR2 nuclear receptor corepressor 2 0.0279723
BRD2 bromodomain containing 2 0.0277541
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0276372
PATJ PATJ crumbs cell polarity complex component 0.0276317
TBCA tubulin folding cofactor A 0.0266251
TMF1 TATA element modulatory factor 1 0.0264855
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0261853
BPTF bromodomain PHD finger transcription factor 0.0259585
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.025851
AGO3 argonaute RISC catalytic component 3 0.0258418
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0257532
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0256908
SDCCAG8 serologically defined colon cancer antigen 8 0.0255548
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0255227
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.025479
AHR aryl hydrocarbon receptor 0.0253854
DEK DEK proto-oncogene 0.0252064
MSN moesin 0.0250596
HILPDA hypoxia inducible lipid droplet-associated 0.0250127
CANX calnexin 0.0249279
RPL11 ribosomal protein L11 0.0245274
HSPH1 heat shock 105kDa/110kDa protein 1 0.0244459
RACK1 receptor for activated C kinase 1 0.0243121
PSD3 pleckstrin and Sec7 domain containing 3 0.0242881
BBS9 Bardet-Biedl syndrome 9 0.0242245
RPL32 ribosomal protein L32 0.024164
MAP1B microtubule-associated protein 1B 0.0239385
VMP1 vacuole membrane protein 1 0.0238921
DPYSL3 dihydropyrimidinase-like 3 0.0237766
RPL9 ribosomal protein L9 0.0235066
EXOC6B exocyst complex component 6B 0.0234948
STC1 stanniocalcin 1 0.0231984
CDK6 cyclin-dependent kinase 6 0.0231785
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0226669
RPS2 ribosomal protein S2 0.0226421
RPS27 ribosomal protein S27 0.0226321
PARD3 par-3 family cell polarity regulator 0.0225791
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0224778
RPL15 ribosomal protein L15 0.02241

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.346924
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.113587
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.109797
NAMPT nicotinamide phosphoribosyltransferase -0.104166
COL1A2 collagen, type I, alpha 2 -0.0991927
TRIO trio Rho guanine nucleotide exchange factor -0.0952906
TGFBI transforming growth factor, beta-induced, 68kDa -0.0916943
LOXL2 lysyl oxidase-like 2 -0.0711476
ATP13A3 ATPase type 13A3 -0.0686102
CALU calumenin -0.0676809
PGK1 phosphoglycerate kinase 1 -0.0643453
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0620851
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.061275
GLIS3 GLIS family zinc finger 3 -0.0595383
COL6A2 collagen, type VI, alpha 2 -0.0595098
TMSB10 thymosin beta 10 -0.0581127
FAM13A family with sequence similarity 13, member A -0.0556368
LOX lysyl oxidase -0.0550925
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0533168
RTN4 reticulon 4 -0.0511055
GARS1 glycyl-tRNA synthetase 1 -0.0505511
TENT5A terminal nucleotidyltransferase 5A -0.0502965
F3 coagulation factor III (thromboplastin, tissue factor) -0.0495974
CADM1 cell adhesion molecule 1 -0.0492945
SDC4 syndecan 4 -0.0489136
COL5A1 collagen, type V, alpha 1 -0.0480855
MYH9 myosin, heavy chain 9, non-muscle -0.047963
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0468461
WSB1 WD repeat and SOCS box containing 1 -0.0451818
TRA2A transformer 2 alpha homolog (Drosophila) -0.04486
ELL2 elongation factor, RNA polymerase II, 2 -0.0448487
MARCHF6 membrane associated ring-CH-type finger 6 -0.044362
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0440793
UBE2H ubiquitin-conjugating enzyme E2H -0.0414238
COL1A1 collagen, type I, alpha 1 -0.0408983
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0405157
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0393983
MAPK8 mitogen-activated protein kinase 8 -0.0384516
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0382327
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0382231
HLA-B major histocompatibility complex, class I, B -0.0382046
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0381295
ANXA2 annexin A2 -0.0380497
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0378295
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0376813
HOOK2 hook microtubule-tethering protein 2 -0.0372908
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0363114
WTAP Wilms tumor 1 associated protein -0.0358652
NOP58 NOP58 ribonucleoprotein -0.0356912
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0354738
MT1X metallothionein 1X -0.035449
ZNF292 zinc finger protein 292 -0.0346888
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0346447
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.034271
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0338913
ZNF395 zinc finger protein 395 -0.0317637
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0313669
HMGA2 high mobility group AT-hook 2 -0.0313281
MATR3 matrin 3 -0.0312906
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0305601
BRWD3 bromodomain and WD repeat domain containing 3 -0.0304678
CUL3 cullin 3 -0.0304454
SOD2 superoxide dismutase 2, mitochondrial -0.0300332
COL6A1 collagen, type VI, alpha 1 -0.029916
FAM20C family with sequence similarity 20, member C -0.0296852
CAV1 caveolin 1, caveolae protein, 22kDa -0.0293613
AVL9 AVL9 homolog (S. cerevisiase) -0.0292522
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0292251
RRBP1 ribosome binding protein 1 -0.0288259
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0287176
CTSB cathepsin B -0.0286079
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.02839
FOXJ3 forkhead box J3 -0.0283891
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0280773
ERBIN erbb2 interacting protein -0.0280556
RBM25 RNA binding motif protein 25 -0.0279476
ABI2 abl-interactor 2 -0.0278483
TMEM41B transmembrane protein 41B -0.0276586
SUB1 SUB1 homolog (S. cerevisiae) -0.0275946
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0270942
EGR1 early growth response 1 -0.0270458
VCL vinculin -0.0266735
USP34 ubiquitin specific peptidase 34 -0.0266221
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0264063
TFG TRK-fused gene -0.026269
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0260807
PTBP2 polypyrimidine tract binding protein 2 -0.0260695
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0260231
CDK7 cyclin-dependent kinase 7 -0.0258584
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0257678
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0254266
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0253812
OSBPL9 oxysterol binding protein-like 9 -0.0251684
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0249649
KLF7 Kruppel-like factor 7 (ubiquitous) -0.024462
FLOT1 flotillin 1 -0.0244572
COL7A1 collagen, type VII, alpha 1 -0.0244517
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0243881
SHB Src homology 2 domain containing adaptor protein B -0.0242975
AUTS2 autism susceptibility candidate 2 -0.0242071