| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.297104 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.175387 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.173606 |
| FLNB | filamin B, beta | 0.114053 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.111815 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0946814 |
| FBN1 | fibrillin 1 | 0.0904032 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0901237 |
| COL5A1 | collagen, type V, alpha 1 | 0.0899348 |
| AHNAK | AHNAK nucleoprotein | 0.0898383 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0894848 |
| CALR | calreticulin | 0.0886464 |
| DST | dystonin | 0.0868635 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0854456 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0847242 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0801845 |
| COL5A2 | collagen, type V, alpha 2 | 0.0763333 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.075669 |
| APP | amyloid beta (A4) precursor protein | 0.0738683 |
| TPM3 | tropomyosin 3 | 0.0698985 |
| C1D | C1D nuclear receptor corepressor | 0.0663591 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.066349 |
| ENO1 | enolase 1, (alpha) | 0.0653081 |
| POTEF | POTE ankyrin domain family, member F | 0.0651404 |
| HDAC9 | histone deacetylase 9 | 0.0623026 |
| PLAT | plasminogen activator, tissue | 0.0620408 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0618012 |
| MSN | moesin | 0.0594236 |
| L1CAM | L1 cell adhesion molecule | 0.0594062 |
| PCBP2 | poly(rC) binding protein 2 | 0.0554554 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0553091 |
| MYOF | myoferlin | 0.0547336 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0541927 |
| FLNA | filamin A, alpha | 0.0509731 |
| LDHA | lactate dehydrogenase A | 0.0509284 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0499245 |
| PKM | pyruvate kinase, muscle | 0.0492607 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0484552 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0454406 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0448022 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0447258 |
| MCL1 | myeloid cell leukemia 1 | 0.0421407 |
| DCLK2 | doublecortin-like kinase 2 | 0.0417802 |
| ADAR | adenosine deaminase, RNA-specific | 0.0417313 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0415582 |
| CANX | calnexin | 0.040589 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0396054 |
| VEGFA | vascular endothelial growth factor A | 0.0386196 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0382735 |
| LOXL2 | lysyl oxidase-like 2 | 0.0381485 |
| PRELID2 | PRELI domain containing 2 | 0.0371622 |
| MYADM | myeloid-associated differentiation marker | 0.0370415 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.036531 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0364259 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0363421 |
| PLEC | plectin | 0.0354933 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0354305 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0346383 |
| B2M | beta-2-microglobulin | 0.0342507 |
| OPTN | optineurin | 0.0335464 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.0332154 |
| EGFR | epidermal growth factor receptor | 0.0322002 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0321886 |
| SFTPA2 | surfactant protein A2 | 0.0320024 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0318194 |
| CD44 | CD44 molecule (Indian blood group) | 0.031721 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0315459 |
| DSPP | dentin sialophosphoprotein | 0.0314372 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0312939 |
| AXL | AXL receptor tyrosine kinase | 0.0312286 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0309657 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0308826 |
| VMP1 | vacuole membrane protein 1 | 0.0305819 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0304202 |
| ASPH | aspartate beta-hydroxylase | 0.0293878 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0289125 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0287271 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0283897 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0280722 |
| SET | SET nuclear proto-oncogene | 0.0278947 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0277451 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0276219 |
| NOTCH2 | notch 2 | 0.027583 |
| SMYD3 | SET and MYND domain containing 3 | 0.0275476 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0275257 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0273481 |
| SEPTIN9 | septin 9 | 0.0265768 |
| RAI1 | retinoic acid induced 1 | 0.0265685 |
| BCL2L1 | BCL2-like 1 | 0.0260834 |
| TPM4 | tropomyosin 4 | 0.0258753 |
| NEK7 | NIMA-related kinase 7 | 0.0256252 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0255452 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0253395 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0253285 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0252451 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0251925 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0250748 |
| ANK2 | ankyrin 2, neuronal | 0.0249704 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0249196 |
| RPL3 | ribosomal protein L3 | 0.0245451 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.210578 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.182861 |
| S100A10 | S100 calcium binding protein A10 | -0.13397 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.120891 |
| HSPB1 | heat shock 27kDa protein 1 | -0.10109 |
| LOX | lysyl oxidase | -0.08225 |
| TMSB10 | thymosin beta 10 | -0.0688526 |
| HLA-B | major histocompatibility complex, class I, B | -0.0664482 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0547164 |
| LMNA | lamin A/C | -0.0520133 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.051678 |
| SQSTM1 | sequestosome 1 | -0.0511217 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0509851 |
| CSTB | cystatin B (stefin B) | -0.0493386 |
| STC1 | stanniocalcin 1 | -0.0491278 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0487657 |
| CCND1 | cyclin D1 | -0.0485589 |
| MEIS2 | Meis homeobox 2 | -0.0479941 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0426312 |
| GPC6 | glypican 6 | -0.0413023 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0407469 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0396479 |
| MAP1B | microtubule-associated protein 1B | -0.039346 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0389279 |
| FRMD4A | FERM domain containing 4A | -0.0380291 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0378752 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0378538 |
| NDRG1 | N-myc downstream regulated 1 | -0.0368717 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0361695 |
| RPS24 | ribosomal protein S24 | -0.0357258 |
| FTL | ferritin, light polypeptide | -0.0354503 |
| HLA-C | major histocompatibility complex, class I, C | -0.0354322 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.034908 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0345469 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0343426 |
| ARF1 | ADP-ribosylation factor 1 | -0.0340444 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0333932 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0331938 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0331933 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.032671 |
| RPL35A | ribosomal protein L35a | -0.0326205 |
| ANXA2 | annexin A2 | -0.0318103 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0315552 |
| GLIS3 | GLIS family zinc finger 3 | -0.0303242 |
| HLA-E | major histocompatibility complex, class I, E | -0.0296642 |
| RPL28 | ribosomal protein L28 | -0.0287579 |
| H3-3B | H3.3 histone B | -0.0287483 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0283539 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0283464 |
| TUBB | tubulin, beta class I | -0.0282547 |
| S100A11 | S100 calcium binding protein A11 | -0.0280874 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0274741 |
| THY1 | Thy-1 cell surface antigen | -0.0268896 |
| PXDN | peroxidasin | -0.0262337 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0261747 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0260375 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0259344 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0248245 |
| CDK6 | cyclin-dependent kinase 6 | -0.0247752 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0245387 |
| CAVIN1 | caveolae associated protein 1 | -0.0244205 |
| RPS15 | ribosomal protein S15 | -0.0241978 |
| ZNF217 | zinc finger protein 217 | -0.0238231 |
| IL7R | interleukin 7 receptor | -0.0236353 |
| NPR2 | natriuretic peptide receptor 2 | -0.0232268 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.023196 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0225981 |
| RPL19 | ribosomal protein L19 | -0.02249 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0223436 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0222936 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | -0.0222769 |
| THBS2 | thrombospondin 2 | -0.0218008 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0214761 |
| UBE2I | ubiquitin-conjugating enzyme E2I | -0.0214392 |
| RPL34 | ribosomal protein L34 | -0.021109 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0210687 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0207916 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0205177 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.02032 |
| CD99 | CD99 molecule | -0.0201483 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0200149 |
| RAI14 | retinoic acid induced 14 | -0.0199419 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0198963 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0198925 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0196904 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0196721 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0196529 |
| RIGI | RNA sensor RIG-I | -0.0194479 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.019387 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0193511 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | -0.0192964 |
| MPZL1 | myelin protein zero-like 1 | -0.0189787 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0189465 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0189052 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.01888 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0186275 |
| TMEM263 | transmembrane protein 263 | -0.0184616 |
| RRBP1 | ribosome binding protein 1 | -0.0184571 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0184339 |
| RPS5 | ribosomal protein S5 | -0.0183192 |
