| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.190212 |
| ANXA1 | annexin A1 | 0.17552 |
| TENM3 | teneurin transmembrane protein 3 | 0.144794 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.105113 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.101451 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0979927 |
| VIM | vimentin | 0.0855021 |
| DST | dystonin | 0.0800343 |
| ACTG1 | actin gamma 1 | 0.0798963 |
| HDAC9 | histone deacetylase 9 | 0.0784549 |
| PCBP2 | poly(rC) binding protein 2 | 0.0776551 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0751209 |
| USP34 | ubiquitin specific peptidase 34 | 0.0714048 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0710408 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0705527 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0702411 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0650148 |
| EPHA6 | EPH receptor A6 | 0.0645171 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0618144 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0613017 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0608792 |
| SYT1 | synaptotagmin I | 0.0602449 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0571528 |
| NEBL | nebulette | 0.0570414 |
| CDK6 | cyclin-dependent kinase 6 | 0.056566 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0551605 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0526126 |
| MYL12B | myosin, light chain 12B, regulatory | 0.052606 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0513315 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0492721 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0491312 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0475614 |
| PLK2 | polo-like kinase 2 | 0.0475212 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0468828 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0454186 |
| KIF5B | kinesin family member 5B | 0.0445294 |
| AXIN2 | axin 2 | 0.0444265 |
| MED13L | mediator complex subunit 13-like | 0.0427503 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0424122 |
| AHNAK | AHNAK nucleoprotein | 0.041712 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0413458 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0412653 |
| MGAT4C | MGAT4 family, member C | 0.0412395 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0408438 |
| EXOC6B | exocyst complex component 6B | 0.0401087 |
| AREG | amphiregulin | 0.039849 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0396236 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.039299 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0390901 |
| EHBP1 | EH domain binding protein 1 | 0.0390127 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0384896 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0384356 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0379975 |
| SQSTM1 | sequestosome 1 | 0.0370965 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0369383 |
| CLDND1 | claudin domain containing 1 | 0.0369232 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0368135 |
| CLDN1 | claudin 1 | 0.0365806 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0363285 |
| SACS | sacsin molecular chaperone | 0.0359599 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0354691 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0353312 |
| FSTL5 | follistatin-like 5 | 0.0345157 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0343751 |
| CLPTM1L | CLPTM1-like | 0.034288 |
| MMP12 | matrix metallopeptidase 12 | 0.0338498 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0336342 |
| AHR | aryl hydrocarbon receptor | 0.033505 |
| TBC1D32 | TBC1 domain family, member 32 | 0.0331627 |
| NRXN3 | neurexin 3 | 0.0331566 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0330763 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0329064 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0327392 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0325839 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0320748 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0316388 |
| RNF213 | ring finger protein 213 | 0.0312949 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.030975 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0308302 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0307169 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0305655 |
| RBM39 | RNA binding motif protein 39 | 0.0299473 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0299348 |
| SPAG9 | sperm associated antigen 9 | 0.0298197 |
| CCNL1 | cyclin L1 | 0.0297449 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0296762 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0296074 |
| JMJD1C | jumonji domain containing 1C | 0.0295825 |
| RPS3 | ribosomal protein S3 | 0.0290537 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0289577 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0287071 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.028683 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0286644 |
| TPI1 | triosephosphate isomerase 1 | 0.0286044 |
| NBEAL1 | neurobeachin-like 1 | 0.0281509 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0280125 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0279522 |
| ZNF638 | zinc finger protein 638 | 0.0277707 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0276212 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0271296 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.171977 |
| PCDH7 | protocadherin 7 | -0.121171 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.102304 |
| ASPH | aspartate beta-hydroxylase | -0.102204 |
| HMGA2 | high mobility group AT-hook 2 | -0.0956265 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0760502 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0716076 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0709043 |
| NHSL1 | NHS-like 1 | -0.0673006 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0668884 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0642719 |
| RPS8 | ribosomal protein S8 | -0.0621218 |
| ZNF804A | zinc finger protein 804A | -0.0597745 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.056348 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0543835 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0526619 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0518003 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0504054 |
| BCHE | butyrylcholinesterase | -0.0497721 |
| RASAL2 | RAS protein activator like 2 | -0.0492737 |
| RPS29 | ribosomal protein S29 | -0.04888 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.045782 |
| TMSB10 | thymosin beta 10 | -0.0428293 |
| RPLP1 | ribosomal protein, large, P1 | -0.0425777 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0385904 |
| MTAP | methylthioadenosine phosphorylase | -0.0384915 |
| TUBB | tubulin, beta class I | -0.0376191 |
| MKI67 | marker of proliferation Ki-67 | -0.0375591 |
| HMGA1 | high mobility group AT-hook 1 | -0.0366702 |
| KCMF1 | potassium channel modulatory factor 1 | -0.035272 |
| PRKCE | protein kinase C, epsilon | -0.0351569 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0338739 |
| EGFR | epidermal growth factor receptor | -0.0337118 |
| RPS23 | ribosomal protein S23 | -0.0333783 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.033283 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0327697 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0319342 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | -0.0317916 |
| RPL23 | ribosomal protein L23 | -0.031545 |
| RPS6 | ribosomal protein S6 | -0.0314181 |
| PTMA | prothymosin, alpha | -0.0312852 |
| RPL36 | ribosomal protein L36 | -0.0306532 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0306352 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0296325 |
| LMO7 | LIM domain 7 | -0.029288 |
| RPL28 | ribosomal protein L28 | -0.0292704 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.029113 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0290074 |
| H1-0 | H1.0 linker histone | -0.0288047 |
| TBCA | tubulin folding cofactor A | -0.0285711 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0273212 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.02646 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0263876 |
| NAV3 | neuron navigator 3 | -0.0262856 |
| RPS27A | ribosomal protein S27a | -0.026253 |
| HMGB1 | high mobility group box 1 | -0.0255309 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.0252759 |
| RPS14 | ribosomal protein S14 | -0.0238268 |
| CDK17 | cyclin-dependent kinase 17 | -0.0236401 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0232343 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0232292 |
| CCND1 | cyclin D1 | -0.0230139 |
| TEAD4 | TEA domain family member 4 | -0.0227528 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0223448 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.0222555 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0221346 |
| TMEM131 | transmembrane protein 131 | -0.0216619 |
| RPL34 | ribosomal protein L34 | -0.0215789 |
| TUBB6 | tubulin, beta 6 class V | -0.0214572 |
| METTL15 | methyltransferase like 15 | -0.021451 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0213916 |
| PKP4 | plakophilin 4 | -0.021381 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0213001 |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase | -0.0211558 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0211076 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0210102 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0208589 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0208027 |
| E2F3 | E2F transcription factor 3 | -0.0207362 |
| WDR45B | WD repeat domain 45B | -0.0207238 |
| RUNX1 | runt-related transcription factor 1 | -0.0206186 |
| RPS20 | ribosomal protein S20 | -0.020613 |
| RPS25 | ribosomal protein S25 | -0.0206017 |
| NABP1 | nucleic acid binding protein 1 | -0.0205377 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0202221 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0202101 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0201753 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.020092 |
| GPHN | gephyrin | -0.0200617 |
| RRM2 | ribonucleotide reductase M2 | -0.0198655 |
| RPL38 | ribosomal protein L38 | -0.0197968 |
| EZR | ezrin | -0.0196512 |
| NF1 | neurofibromin 1 | -0.0195795 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.0194515 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0193456 |
| NUP153 | nucleoporin 153kDa | -0.0192155 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0191873 |
| GMPS | guanine monphosphate synthase | -0.0190865 |
| SUZ12 | SUZ12 polycomb repressive complex 2 subunit | -0.0190275 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0190142 |
