Binimetinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Binimetinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Binimetinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.139417
AHNAK AHNAK nucleoprotein 0.137051
ACTG1 actin gamma 1 0.124668
COL3A1 collagen, type III, alpha 1 0.106579
EEF2 eukaryotic translation elongation factor 2 0.0981586
VIM vimentin 0.0913127
POTEF POTE ankyrin domain family, member F 0.0889287
COL1A1 collagen, type I, alpha 1 0.0853741
ENO1 enolase 1, (alpha) 0.0675146
RNF213 ring finger protein 213 0.0672347
PLPP1 phospholipid phosphatase 1 0.0659084
RPL23 ribosomal protein L23 0.0654234
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0649318
FN1 fibronectin 1 0.0642518
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0551329
CALR calreticulin 0.0550374
PCBP2 poly(rC) binding protein 2 0.054602
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.054587
PTMA prothymosin, alpha 0.0537398
FTL ferritin, light polypeptide 0.0535901
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0524684
UBC ubiquitin C 0.0524561
DST dystonin 0.0507041
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0504099
RPS3 ribosomal protein S3 0.0488207
CANX calnexin 0.0480436
KMT2E lysine (K)-specific methyltransferase 2E 0.0471651
NAP1L1 nucleosome assembly protein 1-like 1 0.0466616
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0454481
NCAM2 neural cell adhesion molecule 2 0.0448723
RPS27A ribosomal protein S27a 0.0434532
MYH9 myosin, heavy chain 9, non-muscle 0.043115
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0430179
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0422185
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0420229
TMSB10 thymosin beta 10 0.0417772
APP amyloid beta (A4) precursor protein 0.0417297
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.041724
PRRC2C proline-rich coiled-coil 2C 0.0415118
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0413853
ZNF292 zinc finger protein 292 0.0412374
N4BP2L2 NEDD4 binding protein 2-like 2 0.0409912
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0406962
NDRG1 N-myc downstream regulated 1 0.0402805
MAP4 microtubule-associated protein 4 0.0389828
SET SET nuclear proto-oncogene 0.038847
CSDE1 cold shock domain containing E1, RNA-binding 0.0384488
MEIS2 Meis homeobox 2 0.0381828
NFE2L1 nuclear factor, erythroid 2-like 1 0.0373887
ANXA2 annexin A2 0.0372034
PKM pyruvate kinase, muscle 0.0370811
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0367442
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0362529
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.03576
CUX1 cut-like homeobox 1 0.0355826
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0354684
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0337859
ARHGAP24 Rho GTPase activating protein 24 0.0327946
SFTPA2 surfactant protein A2 0.0325689
GOLGB1 golgin B1 0.0323872
LDHA lactate dehydrogenase A 0.0323131
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0320754
EZR ezrin 0.0319549
FTH1 ferritin, heavy polypeptide 1 0.0314138
OGA O-GlcNAcase 0.0312546
YLPM1 YLP motif containing 1 0.0312201
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0310129
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0301586
CALU calumenin 0.0297594
WAC WW domain containing adaptor with coiled-coil 0.0296785
KMT2C lysine (K)-specific methyltransferase 2C 0.0296293
TXNRD1 thioredoxin reductase 1 0.0296135
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0293075
ASPH aspartate beta-hydroxylase 0.0292703
PSD3 pleckstrin and Sec7 domain containing 3 0.0292271
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0290249
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0289725
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0289156
LMO7 LIM domain 7 0.0288948
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0288671
MYO6 myosin VI 0.0286962
MAP1B microtubule-associated protein 1B 0.0285766
MATR3 matrin 3 0.0283287
MMP2 matrix metallopeptidase 2 0.0283043
DLC1 DLC1 Rho GTPase activating protein 0.028221
EIF1 eukaryotic translation initiation factor 1 0.028095
IQGAP1 IQ motif containing GTPase activating protein 1 0.0280183
COL4A1 collagen, type IV, alpha 1 0.0277925
PDZRN3 PDZ domain containing ring finger 3 0.0277468
JUN jun proto-oncogene 0.0277277
TIMP3 TIMP metallopeptidase inhibitor 3 0.0274264
ACTN4 actinin, alpha 4 0.0274131
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0270609
SIK3 SIK family kinase 3 0.0266781
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0265691
MBNL2 muscleblind-like splicing regulator 2 0.0265146
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0265113
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0263467
IFI16 interferon, gamma-inducible protein 16 0.0262884
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0262133

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.155108
IGF2 insulin-like growth factor 2 -0.110624
LSAMP limbic system-associated membrane protein -0.0805356
NALF1 NALCN channel auxiliary factor 1 -0.0764092
DPH6 diphthamine biosynthesis 6 -0.0726992
TLE4 transducin-like enhancer of split 4 -0.0708809
TRIO trio Rho guanine nucleotide exchange factor -0.0707735
PLAT plasminogen activator, tissue -0.0698465
EXT1 exostosin glycosyltransferase 1 -0.0678251
THSD4 thrombospondin, type I, domain containing 4 -0.0641123
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0572025
PTPRD protein tyrosine phosphatase, receptor type, D -0.0538324
STC1 stanniocalcin 1 -0.0509565
RPL38 ribosomal protein L38 -0.0477555
KLHL13 kelch-like family member 13 -0.0467464
PRKCA protein kinase C, alpha -0.0457608
DTNA dystrobrevin, alpha -0.0439386
NPAS2 neuronal PAS domain protein 2 -0.0408237
LIMCH1 LIM and calponin homology domains 1 -0.0407351
GPC5 glypican 5 -0.0405281
PTPRE protein tyrosine phosphatase, receptor type, E -0.0397146
BICD1 bicaudal D homolog 1 (Drosophila) -0.0371756
RPTOR regulatory associated protein of MTOR, complex 1 -0.0370253
TENT5A terminal nucleotidyltransferase 5A -0.0348789
ITPRID2 ITPR interacting domain containing 2 -0.0342856
EGR1 early growth response 1 -0.0340621
TRIB2 tribbles pseudokinase 2 -0.0337656
STXBP5 syntaxin binding protein 5 (tomosyn) -0.032413
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0320588
KDM4C lysine (K)-specific demethylase 4C -0.0319211
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.0313436
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0300736
ANKRD17 ankyrin repeat domain 17 -0.0300401
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0295109
CDC27 cell division cycle 27 -0.0293863
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0289825
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.028816
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0283845
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0282622
AKAP12 A kinase (PRKA) anchor protein 12 -0.0280945
COL4A6 collagen, type IV, alpha 6 -0.0276496
SEC24D SEC24 family member D -0.0272015
ACBD6 acyl-CoA binding domain containing 6 -0.0268862
TCF12 transcription factor 12 -0.0267901
VCL vinculin -0.0267332
RPS24 ribosomal protein S24 -0.0266625
TENM4 teneurin transmembrane protein 4 -0.0266427
DNMBP dynamin binding protein -0.0265655
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0265484
NREP neuronal regeneration related protein -0.0263937
PTPRM protein tyrosine phosphatase, receptor type, M -0.0261611
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0260127
SSH1 slingshot protein phosphatase 1 -0.0259552
MACF1 microtubule-actin crosslinking factor 1 -0.0259136
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0257811
HMGA2 high mobility group AT-hook 2 -0.0255064
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0253203
CFDP1 craniofacial development protein 1 -0.0248628
UNC5C unc-5 homolog C (C. elegans) -0.0248239
NF1 neurofibromin 1 -0.0246476
FNDC3B fibronectin type III domain containing 3B -0.0243666
ARHGAP9 Rho GTPase activating protein 9 -0.0242619
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0238287
TRPS1 trichorhinophalangeal syndrome I -0.0236339
FNDC3A fibronectin type III domain containing 3A -0.0234791
VMP1 vacuole membrane protein 1 -0.0232948
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0226608
BMERB1 bMERB domain containing 1 -0.0224791
SMYD3 SET and MYND domain containing 3 -0.0223754
KCTD16 potassium channel tetramerization domain containing 16 -0.022264
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0222378
KIAA1217 KIAA1217 -0.0222225
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0221934
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0220584
SOS1 son of sevenless homolog 1 (Drosophila) -0.0219264
MEF2A myocyte enhancer factor 2A -0.0216137
EPAS1 endothelial PAS domain protein 1 -0.0216121
HPCAL1 hippocalcin-like 1 -0.0215834
MBTD1 mbt domain containing 1 -0.0214582
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0214147
FNBP1 formin binding protein 1 -0.0213036
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0209526
BCAS3 breast carcinoma amplified sequence 3 -0.020923
UBXN7 UBX domain protein 7 -0.0208351
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0207934
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0207528
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0206024
SUCO SUN domain containing ossification factor -0.0205
RPL34 ribosomal protein L34 -0.0204188
COL4A5 collagen, type IV, alpha 5 -0.0203342
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.020318
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0202211
FBXL20 F-box and leucine-rich repeat protein 20 -0.020162
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.020072
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0200558
SH3PXD2B SH3 and PX domains 2B -0.0197193
SH3RF1 SH3 domain containing ring finger 1 -0.0196132
COL18A1 collagen, type XVIII, alpha 1 -0.0195216
TAS2R14 taste receptor, type 2, member 14 -0.0194972
PRKCE protein kinase C, epsilon -0.0194498