| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MACC1 | metastasis associated in colon cancer 1 | 0.140013 |
| MUC13 | mucin 13, cell surface associated | 0.135709 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0947289 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0912956 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0876138 |
| STK24 | serine/threonine kinase 24 | 0.0831403 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0822944 |
| MYO1E | myosin IE | 0.0785182 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0756109 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.074701 |
| LMO7 | LIM domain 7 | 0.0732681 |
| RNF213 | ring finger protein 213 | 0.0729038 |
| DSPP | dentin sialophosphoprotein | 0.0692352 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.067701 |
| ATP10B | ATPase, class V, type 10B | 0.065718 |
| B2M | beta-2-microglobulin | 0.0641991 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0627423 |
| ENO1 | enolase 1, (alpha) | 0.0616117 |
| SERINC5 | serine incorporator 5 | 0.060856 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0592571 |
| PDZD8 | PDZ domain containing 8 | 0.0582026 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0566092 |
| OCLN | occludin | 0.0564122 |
| ETV6 | ets variant 6 | 0.055688 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0553994 |
| FHL2 | four and a half LIM domains 2 | 0.0529185 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0526571 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0522654 |
| DST | dystonin | 0.0513216 |
| CDHR2 | cadherin-related family member 2 | 0.0503343 |
| JUN | jun proto-oncogene | 0.0497033 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0490341 |
| VMP1 | vacuole membrane protein 1 | 0.0489751 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0489434 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0474926 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0471737 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0461709 |
| ZNF292 | zinc finger protein 292 | 0.0460373 |
| LCN2 | lipocalin 2 | 0.045421 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.044551 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0432143 |
| TRIM2 | tripartite motif containing 2 | 0.0427418 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0424822 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0424463 |
| TMC5 | transmembrane channel-like 5 | 0.0418593 |
| TUFT1 | tuftelin 1 | 0.0415344 |
| TXNIP | thioredoxin interacting protein | 0.0410609 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0403158 |
| DPP4 | dipeptidyl-peptidase 4 | 0.039816 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0391058 |
| AHNAK | AHNAK nucleoprotein | 0.0390245 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0382522 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0381361 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0375153 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0372517 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0370685 |
| FAT1 | FAT atypical cadherin 1 | 0.0370543 |
| DUSP10 | dual specificity phosphatase 10 | 0.0368749 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0364745 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0363691 |
| MX1 | MX dynamin-like GTPase 1 | 0.0360116 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0349894 |
| YAP1 | Yes-associated protein 1 | 0.0345733 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0342649 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0340778 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0337759 |
| PRELID2 | PRELI domain containing 2 | 0.0335143 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.033238 |
| TJP1 | tight junction protein 1 | 0.0331933 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0327454 |
| ATP9A | ATPase, class II, type 9A | 0.0324712 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0323741 |
| KIF16B | kinesin family member 16B | 0.0321082 |
| VEGFA | vascular endothelial growth factor A | 0.0317833 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0317095 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0310755 |
| ITM2B | integral membrane protein 2B | 0.0308911 |
| MLPH | melanophilin | 0.0307751 |
| MYO5B | myosin VB | 0.0307134 |
| ADAR | adenosine deaminase, RNA-specific | 0.0306537 |
| PRSS23 | protease, serine, 23 | 0.0305363 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0302534 |
| KLF6 | Kruppel-like factor 6 | 0.0296794 |
| LIMA1 | LIM domain and actin binding 1 | 0.0296705 |
| RBM47 | RNA binding motif protein 47 | 0.0296069 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0286533 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0284581 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0283331 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0280025 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0279675 |
| PGK1 | phosphoglycerate kinase 1 | 0.027845 |
| ANXA4 | annexin A4 | 0.0276658 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.027408 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0273876 |
| SIK3 | SIK family kinase 3 | 0.0271769 |
| MCL1 | myeloid cell leukemia 1 | 0.0270015 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0267028 |
| MX2 | MX dynamin-like GTPase 2 | 0.0266156 |
| USP12 | ubiquitin specific peptidase 12 | 0.0265463 |
| USP54 | ubiquitin specific peptidase 54 | 0.0265245 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.245839 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.1223 |
| EGR1 | early growth response 1 | -0.107617 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.105759 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.105729 |
| H1-0 | H1.0 linker histone | -0.0964053 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0928999 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0853655 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0825045 |
| RUNX1 | runt-related transcription factor 1 | -0.0797739 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0685671 |
| ATP11A | ATPase, class VI, type 11A | -0.0673848 |
| ANKRD10 | ankyrin repeat domain 10 | -0.066306 |
| ITGA6 | integrin, alpha 6 | -0.0662844 |
| XAF1 | XIAP associated factor 1 | -0.0645073 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0627101 |
| TNS4 | tensin 4 | -0.0594183 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0550581 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0546659 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0533175 |
| NF1 | neurofibromin 1 | -0.0517478 |
| MAP7 | microtubule-associated protein 7 | -0.0513141 |
| RPS6 | ribosomal protein S6 | -0.0511595 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0500653 |
| AHI1 | Abelson helper integration site 1 | -0.0497833 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0495758 |
| SQSTM1 | sequestosome 1 | -0.0469164 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0456569 |
| ARF1 | ADP-ribosylation factor 1 | -0.0452804 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0450238 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0440124 |
| SPATA13 | spermatogenesis associated 13 | -0.0437734 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0434866 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0413207 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0409577 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0406284 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0406244 |
| RRBP1 | ribosome binding protein 1 | -0.0403813 |
| ABLIM1 | actin binding LIM protein 1 | -0.0403361 |
| IRF1 | interferon regulatory factor 1 | -0.040054 |
| LYZ | lysozyme | -0.0392726 |
| HM13 | histocompatibility (minor) 13 | -0.0390215 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0387074 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0381992 |
| HDAC4 | histone deacetylase 4 | -0.0379263 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0378158 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0376896 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0364386 |
| RPL34 | ribosomal protein L34 | -0.0357136 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0356707 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0349571 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.034934 |
| HLA-B | major histocompatibility complex, class I, B | -0.0346753 |
| GNAS | GNAS complex locus | -0.0343778 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0337673 |
| NPSR1 | neuropeptide S receptor 1 | -0.0336247 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0334831 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.033161 |
| MORF4L2 | mortality factor 4 like 2 | -0.0328292 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0325632 |
| PERP | PERP, TP53 apoptosis effector | -0.0324341 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | -0.0317297 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0312767 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0312103 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0311882 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0311192 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0308209 |
| RIGI | RNA sensor RIG-I | -0.0303613 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0301243 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0297752 |
| PRKCA | protein kinase C, alpha | -0.0292459 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0292 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0291019 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0287286 |
| HMGB1 | high mobility group box 1 | -0.0283187 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0283108 |
| CDK6 | cyclin-dependent kinase 6 | -0.0281933 |
| MSI2 | musashi RNA-binding protein 2 | -0.0278028 |
| PTMA | prothymosin, alpha | -0.0277793 |
| PCED1B | PC-esterase domain containing 1B | -0.0277176 |
| TMEM87A | transmembrane protein 87A | -0.0276751 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0276479 |
| INTS6 | integrator complex subunit 6 | -0.0276206 |
| THOC2 | THO complex 2 | -0.0276198 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0274726 |
| PMM2 | phosphomannomutase 2 | -0.0274607 |
| AGR2 | anterior gradient 2 | -0.0273548 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0271877 |
| FUS | FUS RNA binding protein | -0.0271436 |
| MKI67 | marker of proliferation Ki-67 | -0.0270808 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0269921 |
| WDR45B | WD repeat domain 45B | -0.0267729 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0267463 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.026199 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0259368 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -0.0257766 |
| GOLGB1 | golgin B1 | -0.0257386 |
| PLSCR1 | phospholipid scramblase 1 | -0.0256825 |
| MUC20 | mucin 20, cell surface associated | -0.0253525 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.0253434 |
