Binimetinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Binimetinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Binimetinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.222601
FN1 fibronectin 1 0.192433
MYH9 myosin, heavy chain 9, non-muscle 0.184551
CALR calreticulin 0.175485
ENO1 enolase 1, (alpha) 0.171439
EEF2 eukaryotic translation elongation factor 2 0.128987
PABPC1 poly(A) binding protein, cytoplasmic 1 0.113298
LDHA lactate dehydrogenase A 0.109532
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.107281
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0973783
VEGFA vascular endothelial growth factor A 0.0896417
ACTG1 actin gamma 1 0.0881408
PSD3 pleckstrin and Sec7 domain containing 3 0.0811612
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0720239
VIM vimentin 0.0719318
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0694571
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0677853
AHNAK AHNAK nucleoprotein 0.0668436
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.066317
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0645079
ZBTB20 zinc finger and BTB domain containing 20 0.0565835
CANX calnexin 0.0537688
PCBP2 poly(rC) binding protein 2 0.0531316
ANKRD11 ankyrin repeat domain 11 0.053121
HYOU1 hypoxia up-regulated 1 0.0522804
COL4A1 collagen, type IV, alpha 1 0.0521727
APP amyloid beta (A4) precursor protein 0.0509962
B2M beta-2-microglobulin 0.0508921
NFE2L1 nuclear factor, erythroid 2-like 1 0.0490236
COL3A1 collagen, type III, alpha 1 0.0479847
RPL3 ribosomal protein L3 0.0467121
EIF4A1 eukaryotic translation initiation factor 4A1 0.0463813
PKM pyruvate kinase, muscle 0.0453993
POTEF POTE ankyrin domain family, member F 0.0450794
ENO2 enolase 2 (gamma, neuronal) 0.0448552
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0447954
VMP1 vacuole membrane protein 1 0.0440414
AXL AXL receptor tyrosine kinase 0.0437193
PLEC plectin 0.0435406
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0431925
PTMA prothymosin, alpha 0.0413797
IFI6 interferon, alpha-inducible protein 6 0.0411234
RPS3 ribosomal protein S3 0.0398551
CALU calumenin 0.0397654
CSDE1 cold shock domain containing E1, RNA-binding 0.0396979
LOXL2 lysyl oxidase-like 2 0.0389526
EIF1 eukaryotic translation initiation factor 1 0.0366539
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.036493
RIGI RNA sensor RIG-I 0.0362448
HDAC9 histone deacetylase 9 0.0360387
GOLGB1 golgin B1 0.0356219
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0351056
COL1A2 collagen, type I, alpha 2 0.0342464
ANXA1 annexin A1 0.0339334
TPM3 tropomyosin 3 0.0333388
IGFBP7 insulin-like growth factor binding protein 7 0.0328044
MBNL1 muscleblind-like splicing regulator 1 0.0324193
COL5A1 collagen, type V, alpha 1 0.0319806
COL7A1 collagen, type VII, alpha 1 0.0316396
YBX1 Y box binding protein 1 0.0312347
BRD2 bromodomain containing 2 0.0307841
DPYSL3 dihydropyrimidinase-like 3 0.0303099
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0293641
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0293397
SP100 SP100 nuclear antigen 0.0292394
SFTPA2 surfactant protein A2 0.028935
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0288627
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0281182
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0277141
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.027388
PDIA6 protein disulfide isomerase family A, member 6 0.0272532
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0271984
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0271467
FLNA filamin A, alpha 0.0270068
TPM4 tropomyosin 4 0.026697
GOLGA2 golgin A2 0.0264073
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0263674
ADAR adenosine deaminase, RNA-specific 0.0262942
LNPEP leucyl/cystinyl aminopeptidase 0.0262322
FLNB filamin B, beta 0.0255781
FAM20C family with sequence similarity 20, member C 0.025473
THRAP3 thyroid hormone receptor associated protein 3 0.0252948
COPA coatomer protein complex, subunit alpha 0.0251794
FBN1 fibrillin 1 0.0247227
BIRC6 baculoviral IAP repeat containing 6 0.0246657
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0246318
MCL1 myeloid cell leukemia 1 0.0244438
MACF1 microtubule-actin crosslinking factor 1 0.0241489
ATF4 activating transcription factor 4 0.0235514
ARHGAP35 Rho GTPase activating protein 35 0.0233843
DSTN destrin (actin depolymerizing factor) 0.0233146
CDK13 cyclin-dependent kinase 13 0.0232809
IQGAP1 IQ motif containing GTPase activating protein 1 0.0232491
NOTCH2 notch 2 0.0231562
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.0231053
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0230729
CSNK1A1 casein kinase 1, alpha 1 0.0229628
AKAP9 A kinase (PRKA) anchor protein 9 0.0225596
CHD9 chromodomain helicase DNA binding protein 9 0.0224597
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0224008

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.167178
IER3 immediate early response 3 -0.162901
CD44 CD44 molecule (Indian blood group) -0.134312
STC1 stanniocalcin 1 -0.132448
CXCL8 chemokine (C-X-C motif) ligand 8 -0.117662
ELL2 elongation factor, RNA polymerase II, 2 -0.107144
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0971086
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.07952
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0778082
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0769781
TM4SF1 transmembrane 4 L six family member 1 -0.0715771
PDE10A phosphodiesterase 10A -0.068631
NDRG1 N-myc downstream regulated 1 -0.0648962
RUNX1 runt-related transcription factor 1 -0.0622378
EXT1 exostosin glycosyltransferase 1 -0.0621442
INHBA inhibin, beta A -0.0606224
CDH13 cadherin 13 -0.0572702
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0561383
ATP13A3 ATPase type 13A3 -0.0560843
BHLHE40 basic helix-loop-helix family, member e40 -0.0536011
NAMPT nicotinamide phosphoribosyltransferase -0.0533094
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0528524
IL6ST interleukin 6 signal transducer -0.0517942
FNDC3B fibronectin type III domain containing 3B -0.0517069
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0481906
CADM1 cell adhesion molecule 1 -0.0475991
HMGA2 high mobility group AT-hook 2 -0.0471489
DPYD dihydropyrimidine dehydrogenase -0.0469478
F3 coagulation factor III (thromboplastin, tissue factor) -0.0468179
JARID2 jumonji, AT rich interactive domain 2 -0.0458536
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0454776
MTSS1 metastasis suppressor 1 -0.0454264
ANTXR2 anthrax toxin receptor 2 -0.0453156
ZFAND3 zinc finger, AN1-type domain 3 -0.0446059
GLIS3 GLIS family zinc finger 3 -0.0441273
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0434305
LTBP1 latent transforming growth factor beta binding protein 1 -0.0411681
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0406996
CLMP CXADR-like membrane protein -0.0404554
RLF rearranged L-myc fusion -0.0395154
COL1A1 collagen, type I, alpha 1 -0.0395144
OSMR oncostatin M receptor -0.0394666
H1-0 H1.0 linker histone -0.0389549
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0388259
RPL35A ribosomal protein L35a -0.0386242
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0375638
RTN4 reticulon 4 -0.0366672
QKI QKI, KH domain containing, RNA binding -0.0362622
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0361664
TPT1 tumor protein, translationally-controlled 1 -0.0359958
ZNF292 zinc finger protein 292 -0.0336411
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0333302
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.0324869
THY1 Thy-1 cell surface antigen -0.0320634
PTK2 protein tyrosine kinase 2 -0.0319206
RASA2 RAS p21 protein activator 2 -0.0317438
UBC ubiquitin C -0.0309937
KDM7A lysine (K)-specific demethylase 7A -0.0307411
SNX9 sorting nexin 9 -0.0307366
MYO10 myosin X -0.0304963
HAS2 hyaluronan synthase 2 -0.0303662
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0301635
S100A10 S100 calcium binding protein A10 -0.0301551
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0299218
COL6A1 collagen, type VI, alpha 1 -0.0294579
RPL12 ribosomal protein L12 -0.0294352
CLIC4 chloride intracellular channel 4 -0.0292989
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0292069
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0292034
ABI3BP ABI family, member 3 (NESH) binding protein -0.0289714
ALCAM activated leukocyte cell adhesion molecule -0.0287243
SEC24A SEC24 family member A -0.0284871
BNC2 basonuclin 2 -0.0282901
NALF1 NALCN channel auxiliary factor 1 -0.0277289
GOLT1B golgi transport 1B -0.0277268
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0270239
FRMD4A FERM domain containing 4A -0.0268561
DLG1 discs, large homolog 1 (Drosophila) -0.0268048
TRAM1 translocation associated membrane protein 1 -0.0265742
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0265485
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0260789
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0259905
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0256845
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0254287
MAPK8 mitogen-activated protein kinase 8 -0.0252297
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0251716
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0250898
TMEM263 transmembrane protein 263 -0.0250477
PXDN peroxidasin -0.0249648
RPS6 ribosomal protein S6 -0.0247823
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0247333
USP3 ubiquitin specific peptidase 3 -0.0243682
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0241763
TSC22D2 TSC22 domain family, member 2 -0.0240514
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0239052
RPL34 ribosomal protein L34 -0.0238089
ADM adrenomedullin -0.0236083
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0232829
NAV2 neuron navigator 2 -0.0232455
HMGA1 high mobility group AT-hook 1 -0.023019