| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.223602 |
| C3 | complement component 3 | 0.197487 |
| DSPP | dentin sialophosphoprotein | 0.160277 |
| TF | transferrin | 0.11654 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0927429 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0896361 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0834935 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0829149 |
| ITGAV | integrin, alpha V | 0.082802 |
| ENO1 | enolase 1, (alpha) | 0.0819475 |
| VMP1 | vacuole membrane protein 1 | 0.080763 |
| DST | dystonin | 0.0747637 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.070559 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0698296 |
| IGF2 | insulin-like growth factor 2 | 0.0693535 |
| VCL | vinculin | 0.0684942 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0679324 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.067089 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0650756 |
| CFB | complement factor B | 0.0581704 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0579806 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0560781 |
| RPL3 | ribosomal protein L3 | 0.054209 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0536936 |
| PCBP2 | poly(rC) binding protein 2 | 0.0485993 |
| GK | glycerol kinase | 0.0475323 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0446042 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0444969 |
| ZNF644 | zinc finger protein 644 | 0.0441063 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0438529 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0430169 |
| RPS27A | ribosomal protein S27a | 0.0426738 |
| MSI2 | musashi RNA-binding protein 2 | 0.0417604 |
| ENAH | enabled homolog (Drosophila) | 0.0407167 |
| POTEF | POTE ankyrin domain family, member F | 0.0402484 |
| SMYD3 | SET and MYND domain containing 3 | 0.0399494 |
| SMAD3 | SMAD family member 3 | 0.0397598 |
| VEGFA | vascular endothelial growth factor A | 0.0391957 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0388653 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0386833 |
| CPE | carboxypeptidase E | 0.0378946 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0375706 |
| AHSG | alpha-2-HS-glycoprotein | 0.0371642 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0368871 |
| FN1 | fibronectin 1 | 0.0360203 |
| CADM1 | cell adhesion molecule 1 | 0.035796 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.035746 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0349415 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0347978 |
| TNS3 | tensin 3 | 0.0347147 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0342531 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0340081 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0335327 |
| JUN | jun proto-oncogene | 0.0334891 |
| TCIM | transcriptional and immune response regulator | 0.0328987 |
| CMIP | c-Maf inducing protein | 0.0327626 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0319385 |
| SKI | SKI proto-oncogene | 0.0309467 |
| RPL4 | ribosomal protein L4 | 0.0299144 |
| SIK3 | SIK family kinase 3 | 0.0297006 |
| PTCHD4 | patched domain containing 4 | 0.029581 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0295758 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0289858 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0287543 |
| CCNY | cyclin Y | 0.0282287 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0276905 |
| TPM1 | tropomyosin 1 (alpha) | 0.0276655 |
| BRD4 | bromodomain containing 4 | 0.0275673 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0275512 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0272487 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.027046 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0270233 |
| FLNB | filamin B, beta | 0.0269301 |
| FHIT | fragile histidine triad | 0.0268836 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0265273 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0264358 |
| SYNJ2 | synaptojanin 2 | 0.0261349 |
| OPTN | optineurin | 0.0261304 |
| SLC2A14 | solute carrier family 2 (facilitated glucose transporter), member 14 | 0.025712 |
| KYNU | kynureninase | 0.0254579 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0253323 |
| CCN2 | cellular communication network factor 2 | 0.0251924 |
| RSU1 | Ras suppressor protein 1 | 0.0251666 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.0250696 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0244691 |
| RNF213 | ring finger protein 213 | 0.0244338 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.024319 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0238075 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0237107 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0236389 |
| XPOT | exportin, tRNA | 0.0235501 |
| ACTG1 | actin gamma 1 | 0.0234522 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0234115 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0233819 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.023175 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0230935 |
| SDC4 | syndecan 4 | 0.0229142 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0228485 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0226494 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0222466 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.207471 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.165862 |
| SLC38A2 | solute carrier family 38, member 2 | -0.156079 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.110419 |
| EHBP1 | EH domain binding protein 1 | -0.110268 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.100275 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0985283 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0910967 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0807514 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0801878 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0788519 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0772425 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0749883 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.072462 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.070329 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.066062 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0647414 |
| RPS24 | ribosomal protein S24 | -0.0629015 |
| H1-0 | H1.0 linker histone | -0.0621787 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0612412 |
| FRMD5 | FERM domain containing 5 | -0.0603447 |
| GNAS | GNAS complex locus | -0.0589288 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0582538 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0569247 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0563974 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0561892 |
| HMGA1 | high mobility group AT-hook 1 | -0.0527198 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0526723 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0474142 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0472207 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.047053 |
| OSMR | oncostatin M receptor | -0.046039 |
| MT2A | metallothionein 2A | -0.0459346 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0449808 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0447717 |
| WDR45B | WD repeat domain 45B | -0.0447576 |
| TMEM123 | transmembrane protein 123 | -0.0439877 |
| APOA2 | apolipoprotein A-II | -0.0419456 |
| ITGA1 | integrin, alpha 1 | -0.0419451 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0418646 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0417587 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0414538 |
| TMSB10 | thymosin beta 10 | -0.0399262 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0386381 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0385306 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0382206 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0380001 |
| RUNX1 | runt-related transcription factor 1 | -0.0378621 |
| RPL35A | ribosomal protein L35a | -0.0375699 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0373845 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0367436 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0357561 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0354051 |
| RPL11 | ribosomal protein L11 | -0.0354037 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.035196 |
| ASPH | aspartate beta-hydroxylase | -0.0347321 |
| APOA1 | apolipoprotein A-I | -0.0345672 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0341732 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0333623 |
| CP | ceruloplasmin (ferroxidase) | -0.0330567 |
| RAI14 | retinoic acid induced 14 | -0.0330307 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.032967 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0327435 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0312384 |
| NHSL1 | NHS-like 1 | -0.0310258 |
| APOE | apolipoprotein E | -0.0307984 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0305728 |
| ATP10A | ATPase, class V, type 10A | -0.0302833 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0300951 |
| NPR2 | natriuretic peptide receptor 2 | -0.0298492 |
| GPC6 | glypican 6 | -0.0287039 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0284615 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0278188 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0277794 |
| RPS6 | ribosomal protein S6 | -0.0277636 |
| RNASET2 | ribonuclease T2 | -0.0275994 |
| ITGB5 | integrin, beta 5 | -0.0273322 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | -0.0265267 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0259036 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0258425 |
| GPATCH8 | G patch domain containing 8 | -0.0249373 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0248827 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.024488 |
| RYBP | RING1 and YY1 binding protein | -0.0240727 |
| RPL38 | ribosomal protein L38 | -0.0239913 |
| RLF | rearranged L-myc fusion | -0.0237145 |
| RPL19 | ribosomal protein L19 | -0.0236795 |
| RPL34 | ribosomal protein L34 | -0.0236196 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0234823 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0233838 |
| CRLS1 | cardiolipin synthase 1 | -0.0231088 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | -0.0230388 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0224961 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0224205 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0223746 |
| PEG3 | paternally expressed 3 | -0.0221062 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0219053 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.021741 |
| SQSTM1 | sequestosome 1 | -0.0217333 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0217068 |
