| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT17 | keratin 17, type I | 0.134627 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.131784 |
| AHNAK | AHNAK nucleoprotein | 0.109482 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.106057 |
| ENO1 | enolase 1, (alpha) | 0.0820221 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0819018 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0717976 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0695737 |
| IFI44L | interferon-induced protein 44-like | 0.0672037 |
| POTEF | POTE ankyrin domain family, member F | 0.0657272 |
| MYOF | myoferlin | 0.0656894 |
| SULF1 | sulfatase 1 | 0.06478 |
| AOPEP | aminopeptidase O (putative) | 0.0600097 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0596016 |
| KRT14 | keratin 14, type I | 0.058016 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0561031 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0558045 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0556616 |
| ANXA1 | annexin A1 | 0.0548112 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0536927 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0501414 |
| NEK7 | NIMA-related kinase 7 | 0.0501177 |
| CALR | calreticulin | 0.0500192 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0484018 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0479922 |
| EGFR | epidermal growth factor receptor | 0.0467229 |
| B2M | beta-2-microglobulin | 0.0466058 |
| MX1 | MX dynamin-like GTPase 1 | 0.0465229 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0459307 |
| ITGB8 | integrin, beta 8 | 0.045055 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0425764 |
| ADAR | adenosine deaminase, RNA-specific | 0.0400932 |
| CLU | clusterin | 0.0398377 |
| TXNIP | thioredoxin interacting protein | 0.039511 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0390357 |
| MXRA5 | matrix-remodelling associated 5 | 0.0386175 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0383166 |
| IFI44 | interferon-induced protein 44 | 0.0382997 |
| PALLD | palladin, cytoskeletal associated protein | 0.0378759 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.037735 |
| YBX1 | Y box binding protein 1 | 0.0376304 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0375915 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0371852 |
| SAMHD1 | SAM domain and HD domain 1 | 0.0370484 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0367464 |
| UBC | ubiquitin C | 0.0364559 |
| DSG2 | desmoglein 2 | 0.0361772 |
| EHF | ets homologous factor | 0.0340528 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0338461 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0335805 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.033323 |
| MECOM | MDS1 and EVI1 complex locus | 0.0331988 |
| PLPP1 | phospholipid phosphatase 1 | 0.0330752 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0330598 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0330565 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0325338 |
| TXNRD1 | thioredoxin reductase 1 | 0.0323875 |
| LDHA | lactate dehydrogenase A | 0.0321629 |
| THBS1 | thrombospondin 1 | 0.0317782 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0311092 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0310035 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0307305 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0305208 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0303325 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0303289 |
| CLDN1 | claudin 1 | 0.0294562 |
| TSC22D1 | TSC22 domain family, member 1 | 0.029421 |
| LMO4 | LIM domain only 4 | 0.0292743 |
| KRT6A | keratin 6A, type II | 0.0290541 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0289005 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0286007 |
| RIGI | RNA sensor RIG-I | 0.0285384 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.028314 |
| EXOC6B | exocyst complex component 6B | 0.0281437 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.028117 |
| RNF213 | ring finger protein 213 | 0.0281105 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0277809 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | 0.0277151 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0275306 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0273706 |
| PTMA | prothymosin, alpha | 0.0272155 |
| SLC45A4 | solute carrier family 45, member 4 | 0.0269138 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.026769 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0267187 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0264602 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0262807 |
| MX2 | MX dynamin-like GTPase 2 | 0.0262241 |
| KRT5 | keratin 5, type II | 0.0261894 |
| PLCE1 | phospholipase C, epsilon 1 | 0.0258895 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0258746 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0258245 |
| TGM2 | transglutaminase 2 | 0.0257729 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.025742 |
| DOK5 | docking protein 5 | 0.0255205 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0254145 |
| TMSB4X | thymosin beta 4, X-linked | 0.0254018 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0251036 |
| AUTS2 | autism susceptibility candidate 2 | 0.0250427 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.0247839 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0246752 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.241938 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.210338 |
| STC1 | stanniocalcin 1 | -0.157919 |
| MTSS1 | metastasis suppressor 1 | -0.122881 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.120598 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.104336 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0911833 |
| ITGA6 | integrin, alpha 6 | -0.0827462 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0807461 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0760318 |
| FLNB | filamin B, beta | -0.0759674 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.075484 |
| CUL4B | cullin 4B | -0.0732344 |
| NAV2 | neuron navigator 2 | -0.0655991 |
| RAI14 | retinoic acid induced 14 | -0.0638167 |
| MT2A | metallothionein 2A | -0.0628536 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0604402 |
| RPS6 | ribosomal protein S6 | -0.0603321 |
| RPS21 | ribosomal protein S21 | -0.0568553 |
| MYO10 | myosin X | -0.056644 |
| RIN2 | Ras and Rab interactor 2 | -0.0552553 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0536345 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0529575 |
| ASPH | aspartate beta-hydroxylase | -0.0518789 |
| HMGA2 | high mobility group AT-hook 2 | -0.0510882 |
| RBM39 | RNA binding motif protein 39 | -0.0498393 |
| LAMC2 | laminin, gamma 2 | -0.0491562 |
| PODXL | podocalyxin-like | -0.0471537 |
| EMP1 | epithelial membrane protein 1 | -0.0471166 |
| DUSP6 | dual specificity phosphatase 6 | -0.0457988 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0443661 |
| RPL11 | ribosomal protein L11 | -0.0433085 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0432298 |
| MEF2A | myocyte enhancer factor 2A | -0.0431048 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0426377 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0418624 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0411356 |
| PTK2 | protein tyrosine kinase 2 | -0.0401371 |
| CDK6 | cyclin-dependent kinase 6 | -0.0398809 |
| RPS13 | ribosomal protein S13 | -0.0390806 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0389811 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0389632 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0377178 |
| FOSL1 | FOS-like antigen 1 | -0.0366899 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.03629 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.036054 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0358714 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0355146 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0354924 |
| CAPRIN2 | caprin family member 2 | -0.0353455 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0351273 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0344015 |
| RPL8 | ribosomal protein L8 | -0.0341882 |
| CD44 | CD44 molecule (Indian blood group) | -0.0341372 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.033809 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0336697 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0336331 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0331548 |
| GNAS | GNAS complex locus | -0.0331175 |
| EFHD2 | EF-hand domain family, member D2 | -0.0328832 |
| TOP1 | topoisomerase (DNA) I | -0.032636 |
| RTN4 | reticulon 4 | -0.0325592 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0324297 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0321865 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0320758 |
| GOLGA4 | golgin A4 | -0.0320533 |
| ACER3 | alkaline ceramidase 3 | -0.0319781 |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase | -0.0318746 |
| DUSP4 | dual specificity phosphatase 4 | -0.0309616 |
| SPAG9 | sperm associated antigen 9 | -0.0308655 |
| RLF | rearranged L-myc fusion | -0.030544 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0298116 |
| RPS8 | ribosomal protein S8 | -0.0292856 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0289644 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0287597 |
| OSBPL6 | oxysterol binding protein-like 6 | -0.0286457 |
| ANLN | anillin, actin binding protein | -0.0285157 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0285146 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0282564 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0281766 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.028031 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.028015 |
| RPS24 | ribosomal protein S24 | -0.0278438 |
| RPL35A | ribosomal protein L35a | -0.0276383 |
| RASA3 | RAS p21 protein activator 3 | -0.0274862 |
| RPL26 | ribosomal protein L26 | -0.0274457 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0273053 |
| RPL28 | ribosomal protein L28 | -0.0270939 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0269824 |
| RPS25 | ribosomal protein S25 | -0.0268929 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0265 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0263578 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0262609 |
| RPLP2 | ribosomal protein, large, P2 | -0.0260047 |
| CDCP1 | CUB domain containing protein 1 | -0.0257951 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0257345 |
| KIAA1217 | KIAA1217 | -0.0254143 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0252165 |
| OSMR | oncostatin M receptor | -0.0251253 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0250808 |
