| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.323717 |
| PTMA | prothymosin, alpha | 0.22292 |
| DSPP | dentin sialophosphoprotein | 0.156145 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.118913 |
| ITGA6 | integrin, alpha 6 | 0.113137 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.101682 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0951528 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0940191 |
| MUC13 | mucin 13, cell surface associated | 0.0936881 |
| ENO1 | enolase 1, (alpha) | 0.0933209 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0912014 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0790274 |
| GPHN | gephyrin | 0.078252 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.075508 |
| PTEN | phosphatase and tensin homolog | 0.072368 |
| AHNAK | AHNAK nucleoprotein | 0.0691193 |
| CALR | calreticulin | 0.0689529 |
| TRIM2 | tripartite motif containing 2 | 0.0684426 |
| FOXP1 | forkhead box P1 | 0.0655545 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.061292 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.060523 |
| SHROOM3 | shroom family member 3 | 0.0598283 |
| EREG | epiregulin | 0.0595447 |
| PIGR | polymeric immunoglobulin receptor | 0.0592505 |
| LDHA | lactate dehydrogenase A | 0.0562712 |
| EZR | ezrin | 0.0558883 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0552106 |
| PCBP2 | poly(rC) binding protein 2 | 0.0548347 |
| NEBL | nebulette | 0.0543503 |
| EPCAM | epithelial cell adhesion molecule | 0.0536838 |
| RPL3 | ribosomal protein L3 | 0.0529131 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0521967 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 0.0516662 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0514011 |
| ADD3 | adducin 3 (gamma) | 0.050911 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0500884 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0485896 |
| MLEC | malectin | 0.0484913 |
| PDZD8 | PDZ domain containing 8 | 0.0462824 |
| VEGFA | vascular endothelial growth factor A | 0.0448024 |
| GOLGA4 | golgin A4 | 0.0443457 |
| TPD52 | tumor protein D52 | 0.0442899 |
| EPHB2 | EPH receptor B2 | 0.0432042 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0431947 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0427184 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0426578 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0424428 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0409544 |
| FAM13A | family with sequence similarity 13, member A | 0.0407088 |
| ABLIM1 | actin binding LIM protein 1 | 0.0401084 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0398527 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0397784 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0392729 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0389292 |
| MECOM | MDS1 and EVI1 complex locus | 0.0382411 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0378273 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0372807 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0372328 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.036927 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0364937 |
| CANX | calnexin | 0.0363198 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0361572 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0361347 |
| FNBP1L | formin binding protein 1-like | 0.036023 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0356464 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.0356033 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0355167 |
| APP | amyloid beta (A4) precursor protein | 0.0355144 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0354672 |
| ZNRF3 | zinc and ring finger 3 | 0.0349036 |
| GOLGB1 | golgin B1 | 0.0347967 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0347913 |
| DNM2 | dynamin 2 | 0.0344688 |
| MYO10 | myosin X | 0.0341831 |
| PCM1 | pericentriolar material 1 | 0.033987 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.033901 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0335371 |
| TXNIP | thioredoxin interacting protein | 0.0334657 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0331734 |
| TPM3 | tropomyosin 3 | 0.0331459 |
| NRXN3 | neurexin 3 | 0.033028 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.032546 |
| JUN | jun proto-oncogene | 0.0324523 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0322763 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0322367 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.0317226 |
| PRELID2 | PRELI domain containing 2 | 0.0310879 |
| DENND4C | DENN/MADD domain containing 4C | 0.0310866 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0310392 |
| CASZ1 | castor zinc finger 1 | 0.030965 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0309327 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0305565 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0303895 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0299836 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0299834 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0297993 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0297818 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0297474 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0296458 |
| MYO1E | myosin IE | 0.029624 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.130012 |
| ONECUT3 | one cut homeobox 3 | -0.108974 |
| ANTXR2 | anthrax toxin receptor 2 | -0.107622 |
| TMSB10 | thymosin beta 10 | -0.0928463 |
| TNS4 | tensin 4 | -0.0917556 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0867516 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0832406 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0742411 |
| H1-0 | H1.0 linker histone | -0.0704545 |
| ANXA2 | annexin A2 | -0.0703103 |
| NDRG1 | N-myc downstream regulated 1 | -0.0651816 |
| ASPH | aspartate beta-hydroxylase | -0.063545 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0596804 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0588148 |
| FLNB | filamin B, beta | -0.056377 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0549762 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0531569 |
| S100A10 | S100 calcium binding protein A10 | -0.0521914 |
| RPS6 | ribosomal protein S6 | -0.0521722 |
| IER3 | immediate early response 3 | -0.0512034 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0504611 |
| TPM4 | tropomyosin 4 | -0.0500231 |
| RPL35A | ribosomal protein L35a | -0.048042 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0469702 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0456685 |
| KRT18 | keratin 18, type I | -0.045652 |
| CADPS | Ca++-dependent secretion activator | -0.0428715 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.042446 |
| FERMT1 | fermitin family member 1 | -0.0422797 |
| RPLP1 | ribosomal protein, large, P1 | -0.0414685 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0405849 |
| RPL38 | ribosomal protein L38 | -0.0402382 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0392142 |
| FTL | ferritin, light polypeptide | -0.0388075 |
| HMGB1 | high mobility group box 1 | -0.0385678 |
| RPS19 | ribosomal protein S19 | -0.0380315 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0378718 |
| RPL34 | ribosomal protein L34 | -0.037831 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0359511 |
| NPSR1 | neuropeptide S receptor 1 | -0.0352389 |
| RPS8 | ribosomal protein S8 | -0.0343436 |
| S100P | S100 calcium binding protein P | -0.0340385 |
| RPL36 | ribosomal protein L36 | -0.03366 |
| EGFR | epidermal growth factor receptor | -0.0335362 |
| RPLP2 | ribosomal protein, large, P2 | -0.0334196 |
| LAMA4 | laminin, alpha 4 | -0.0317638 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0314617 |
| VCL | vinculin | -0.0305092 |
| RPS29 | ribosomal protein S29 | -0.0299068 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0291239 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0289611 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0281948 |
| USP53 | ubiquitin specific peptidase 53 | -0.0276913 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0272125 |
| CCND1 | cyclin D1 | -0.0270264 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0269663 |
| MT2A | metallothionein 2A | -0.0261629 |
| RPS24 | ribosomal protein S24 | -0.0254397 |
| SLC38A2 | solute carrier family 38, member 2 | -0.025328 |
| RPL12 | ribosomal protein L12 | -0.0250463 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0250083 |
| HMGA1 | high mobility group AT-hook 1 | -0.0246367 |
| AGR2 | anterior gradient 2 | -0.0245386 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.024016 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0234947 |
| RPL28 | ribosomal protein L28 | -0.0230792 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0225687 |
| RPS23 | ribosomal protein S23 | -0.0225379 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0223859 |
| RPL9 | ribosomal protein L9 | -0.0223374 |
| CDCP1 | CUB domain containing protein 1 | -0.0221725 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.022036 |
| RPS25 | ribosomal protein S25 | -0.0218424 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0215292 |
| ITGB4 | integrin, beta 4 | -0.0214942 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0213111 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0212876 |
| FOSL1 | FOS-like antigen 1 | -0.0211901 |
| RPL32 | ribosomal protein L32 | -0.0208173 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0206347 |
| FOXO1 | forkhead box O1 | -0.0205836 |
| TOP1 | topoisomerase (DNA) I | -0.0202247 |
| RPL31 | ribosomal protein L31 | -0.0201518 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0199104 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0198652 |
| EFNB2 | ephrin-B2 | -0.0198065 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0197892 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0196033 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0194342 |
| KRT19 | keratin 19, type I | -0.0192825 |
| RPS16 | ribosomal protein S16 | -0.0192454 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0190275 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0186856 |
| LAMC2 | laminin, gamma 2 | -0.0186346 |
| RPL37A | ribosomal protein L37a | -0.0186235 |
| RPS27 | ribosomal protein S27 | -0.0185953 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0184802 |
| RPS11 | ribosomal protein S11 | -0.0184395 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0183786 |
| VIM | vimentin | -0.0180876 |
