Binimetinib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Binimetinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Binimetinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TP63 tumor protein p63 0.155022
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.108151
HDAC9 histone deacetylase 9 0.0960217
AHNAK AHNAK nucleoprotein 0.0940884
DLG1 discs, large homolog 1 (Drosophila) 0.093337
TNS3 tensin 3 0.0875234
EFNA5 ephrin-A5 0.0826955
EREG epiregulin 0.0775422
MYOF myoferlin 0.0737696
STXBP5 syntaxin binding protein 5 (tomosyn) 0.073667
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0711676
EPHA4 EPH receptor A4 0.0710563
ENO1 enolase 1, (alpha) 0.0707577
TMSB4X thymosin beta 4, X-linked 0.0676836
LDHA lactate dehydrogenase A 0.0670199
DST dystonin 0.0646454
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0623707
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0599687
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0598524
PLK2 polo-like kinase 2 0.0591094
POTEF POTE ankyrin domain family, member F 0.0535918
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.053504
BIRC3 baculoviral IAP repeat containing 3 0.0531432
TRIO trio Rho guanine nucleotide exchange factor 0.0531244
SQSTM1 sequestosome 1 0.0506018
ENO2 enolase 2 (gamma, neuronal) 0.0500945
ADAR adenosine deaminase, RNA-specific 0.048299
EEF2 eukaryotic translation elongation factor 2 0.0438123
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0434014
RNF213 ring finger protein 213 0.0427175
ADAM10 ADAM metallopeptidase domain 10 0.0418043
KMT2C lysine (K)-specific methyltransferase 2C 0.0411171
SDC4 syndecan 4 0.0403403
SOD2 superoxide dismutase 2, mitochondrial 0.0402086
ERRFI1 ERBB receptor feedback inhibitor 1 0.0401389
EGFR epidermal growth factor receptor 0.0385072
AKAP9 A kinase (PRKA) anchor protein 9 0.0377313
B2M beta-2-microglobulin 0.0376996
ZNF217 zinc finger protein 217 0.0361622
ACTG1 actin gamma 1 0.0342952
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0342913
OPTN optineurin 0.0332612
ZFP36L1 ZFP36 ring finger protein-like 1 0.0328209
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0327433
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0323095
MYH9 myosin, heavy chain 9, non-muscle 0.0313767
PCBP2 poly(rC) binding protein 2 0.0311863
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0310807
WNK1 WNK lysine deficient protein kinase 1 0.0305718
CANX calnexin 0.0289066
ZNF292 zinc finger protein 292 0.028871
GOLGB1 golgin B1 0.0278141
TMEM123 transmembrane protein 123 0.0271509
KMT2A lysine (K)-specific methyltransferase 2A 0.0271476
TTC3 tetratricopeptide repeat domain 3 0.0269292
USP9X ubiquitin specific peptidase 9, X-linked 0.0268951
BPTF bromodomain PHD finger transcription factor 0.0267146
CALR calreticulin 0.0266899
SMYD3 SET and MYND domain containing 3 0.0263078
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.0260986
AHNAK2 AHNAK nucleoprotein 2 0.0256664
HIP1 huntingtin interacting protein 1 0.025355
SPAG9 sperm associated antigen 9 0.025186
CEP350 centrosomal protein 350kDa 0.0249195
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0247021
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0240926
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0239736
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0236974
ANKRD36 ankyrin repeat domain 36 0.0236728
MBNL2 muscleblind-like splicing regulator 2 0.0235408
ARRDC3 arrestin domain containing 3 0.0233579
TPM3 tropomyosin 3 0.0230628
HLA-B major histocompatibility complex, class I, B 0.0228947
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0228896
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0228697
HILPDA hypoxia inducible lipid droplet-associated 0.0228456
ATXN2 ataxin 2 0.022831
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.022811
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0227127
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0227118
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0226892
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0224527
IFITM1 interferon induced transmembrane protein 1 0.0223772
TAOK1 TAO kinase 1 0.0222517
XPO1 exportin 1 0.0222261
KDM2A lysine (K)-specific demethylase 2A 0.0221513
LYST lysosomal trafficking regulator 0.0221511
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0221182
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0220916
SFTPA2 surfactant protein A2 0.0219241
RAD51B RAD51 paralog B 0.0216263
GLG1 golgi glycoprotein 1 0.0214217
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0213102
GOLGA4 golgin A4 0.0211999
DARS1 aspartyl-tRNA synthetase 1 0.0210975
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0209556
LPP LIM domain containing preferred translocation partner in lipoma 0.0207753
PKM pyruvate kinase, muscle 0.0207187
ZBTB20 zinc finger and BTB domain containing 20 0.0206758
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0204681

decreased expression

Symbol Name Standardized Value
TM4SF1 transmembrane 4 L six family member 1 -0.195193
MT2A metallothionein 2A -0.18255
PSD3 pleckstrin and Sec7 domain containing 3 -0.139987
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.11348
FMNL2 formin-like 2 -0.105423
TMSB10 thymosin beta 10 -0.104501
CAPRIN2 caprin family member 2 -0.0951813
PDE10A phosphodiesterase 10A -0.0832367
BCAR3 breast cancer anti-estrogen resistance 3 -0.0829999
ARHGAP5 Rho GTPase activating protein 5 -0.0790901
CD44 CD44 molecule (Indian blood group) -0.0755415
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0736231
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0735184
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0679039
RPL35A ribosomal protein L35a -0.0633035
NT5E 5'-nucleotidase, ecto (CD73) -0.0595359
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0595153
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0594048
EHBP1 EH domain binding protein 1 -0.058416
CFAP299 cilia and flagella associated protein 299 -0.0582756
TPT1 tumor protein, translationally-controlled 1 -0.0581251
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0570757
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0568409
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0564363
GCLM glutamate-cysteine ligase, modifier subunit -0.0545537
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0542508
HMGA1 high mobility group AT-hook 1 -0.0511449
KMT2E lysine (K)-specific methyltransferase 2E -0.0503067
RPS8 ribosomal protein S8 -0.0500906
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0496538
MACF1 microtubule-actin crosslinking factor 1 -0.0478788
RGS4 regulator of G-protein signaling 4 -0.0472975
THSD4 thrombospondin, type I, domain containing 4 -0.0463461
MT1X metallothionein 1X -0.0453718
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0442052
EGR1 early growth response 1 -0.0435624
TXNRD1 thioredoxin reductase 1 -0.0422676
RPL26 ribosomal protein L26 -0.0420484
ZEB1 zinc finger E-box binding homeobox 1 -0.0415506
RPS6 ribosomal protein S6 -0.0414979
SDCCAG8 serologically defined colon cancer antigen 8 -0.0412316
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0411719
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0410181
CMIP c-Maf inducing protein -0.040944
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0396734
SPRY4 sprouty homolog 4 (Drosophila) -0.0392603
PYGB phosphorylase, glycogen; brain -0.0392282
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0386762
PTMA prothymosin, alpha -0.0385074
FLNB filamin B, beta -0.038481
FBXO11 F-box protein 11 -0.0374917
WWTR1 WW domain containing transcription regulator 1 -0.0372319
CADM2 cell adhesion molecule 2 -0.0369462
RAP2B RAP2B, member of RAS oncogene family -0.0364255
STK17A serine/threonine kinase 17a -0.0362465
EMP1 epithelial membrane protein 1 -0.0361842
RAB7A RAB7A, member RAS oncogene family -0.0361133
RPL12 ribosomal protein L12 -0.035815
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0358119
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0356958
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0356253
BZW1 basic leucine zipper and W2 domains 1 -0.0352117
ANTXR2 anthrax toxin receptor 2 -0.0351731
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.035039
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0334253
PYGL phosphorylase, glycogen, liver -0.0333966
RTN4 reticulon 4 -0.0333075
CDK6 cyclin-dependent kinase 6 -0.0331581
WSB1 WD repeat and SOCS box containing 1 -0.0315168
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0315071
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0311298
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.030959
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0309211
APP amyloid beta (A4) precursor protein -0.030655
ADGRG6 adhesion G protein-coupled receptor G6 -0.0305224
CDCP1 CUB domain containing protein 1 -0.0304527
ADARB1 adenosine deaminase, RNA-specific, B1 -0.030102
RPL9 ribosomal protein L9 -0.0294767
UPP1 uridine phosphorylase 1 -0.0293693
TMEM41B transmembrane protein 41B -0.0289999
DOCK11 dedicator of cytokinesis 11 -0.0274605
MCTP1 multiple C2 domains, transmembrane 1 -0.0272114
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0268871
RPS24 ribosomal protein S24 -0.0267354
NAV2 neuron navigator 2 -0.0266182
RBM25 RNA binding motif protein 25 -0.0265144
TRIP12 thyroid hormone receptor interactor 12 -0.0261872
SDK1 sidekick cell adhesion molecule 1 -0.025917
CAPN2 calpain 2, (m/II) large subunit -0.0257725
DNER delta/notch-like EGF repeat containing -0.025565
TOP1 topoisomerase (DNA) I -0.025513
YBX3 Y box binding protein 3 -0.0251574
FERMT1 fermitin family member 1 -0.0247806
RPL5 ribosomal protein L5 -0.0245865
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0244941
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0244712
ERCC1 excision repair cross-complementation group 1 -0.024259
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0240423
DPYD dihydropyrimidine dehydrogenase -0.0237879
SLC38A1 solute carrier family 38, member 1 -0.0233479