| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Binimetinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.172871 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.119698 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.107662 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.104998 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.10475 |
| MYOF | myoferlin | 0.10422 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0959338 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0898969 |
| CPE | carboxypeptidase E | 0.0884136 |
| RNF213 | ring finger protein 213 | 0.087062 |
| DSPP | dentin sialophosphoprotein | 0.0857651 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0846166 |
| ENO1 | enolase 1, (alpha) | 0.0821776 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0808013 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.063993 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0623547 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0609163 |
| HYOU1 | hypoxia up-regulated 1 | 0.0558201 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0546427 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0535623 |
| LDHA | lactate dehydrogenase A | 0.0523416 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0510264 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0482572 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.047733 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0476176 |
| CALR | calreticulin | 0.0468795 |
| LMO7 | LIM domain 7 | 0.0461359 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0460266 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0455839 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0453995 |
| NTN4 | netrin 4 | 0.0444257 |
| IRS2 | insulin receptor substrate 2 | 0.0428037 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0419106 |
| TES | testin LIM domain protein | 0.041835 |
| GOLGB1 | golgin B1 | 0.0418347 |
| PCBP2 | poly(rC) binding protein 2 | 0.0408259 |
| AHR | aryl hydrocarbon receptor | 0.0394639 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0385629 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0370042 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0366946 |
| TUFT1 | tuftelin 1 | 0.0365142 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0349892 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0348049 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0347229 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0346426 |
| PKM | pyruvate kinase, muscle | 0.0333678 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0333328 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.033228 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0331834 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.033143 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0329125 |
| B2M | beta-2-microglobulin | 0.03245 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0323889 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0323519 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0317279 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0315756 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0315511 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0314887 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.031137 |
| YBX3 | Y box binding protein 3 | 0.0309912 |
| CAV2 | caveolin 2 | 0.0306238 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0305695 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0299957 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0297327 |
| KRT7 | keratin 7, type II | 0.0295045 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0294412 |
| TJP1 | tight junction protein 1 | 0.0294163 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0290347 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.028852 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0286455 |
| NFIB | nuclear factor I/B | 0.0283126 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0282119 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0281336 |
| RPL3 | ribosomal protein L3 | 0.0280851 |
| TMF1 | TATA element modulatory factor 1 | 0.0279239 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0277713 |
| NEBL | nebulette | 0.0277248 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0276923 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0276483 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0273747 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0273419 |
| VMP1 | vacuole membrane protein 1 | 0.0271992 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0270149 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0269468 |
| AHNAK | AHNAK nucleoprotein | 0.0266597 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0264221 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0262796 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0262007 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0261798 |
| DST | dystonin | 0.0260199 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0257983 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0250831 |
| CST3 | cystatin C | 0.0250232 |
| PER2 | period circadian clock 2 | 0.0247877 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0244205 |
| GRAMD1B | GRAM domain containing 1B | 0.0243834 |
| CANX | calnexin | 0.0243664 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0239098 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0237902 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0235654 |
| Symbol | Name | Standardized Value |
|---|---|---|
| THSD4 | thrombospondin, type I, domain containing 4 | -0.141158 |
| LAMC2 | laminin, gamma 2 | -0.132722 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.125037 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.108493 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.103509 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.10219 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0951014 |
| H1-0 | H1.0 linker histone | -0.0944475 |
| MT2A | metallothionein 2A | -0.0915342 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.084029 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0805261 |
| STC1 | stanniocalcin 1 | -0.0771822 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0766749 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0755191 |
| TMSB10 | thymosin beta 10 | -0.0732096 |
| CDCP1 | CUB domain containing protein 1 | -0.0714005 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0658266 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0657097 |
| SMAD3 | SMAD family member 3 | -0.0656213 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0644318 |
| NDRG1 | N-myc downstream regulated 1 | -0.0639984 |
| SLTM | SAFB-like, transcription modulator | -0.0636014 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0581985 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0552655 |
| TOP1 | topoisomerase (DNA) I | -0.0545756 |
| EGFR | epidermal growth factor receptor | -0.0533786 |
| RASA2 | RAS p21 protein activator 2 | -0.0521448 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0508691 |
| IER3 | immediate early response 3 | -0.0486523 |
| MCL1 | myeloid cell leukemia 1 | -0.0479343 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0478363 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0472833 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0472737 |
| LAMA4 | laminin, alpha 4 | -0.0457151 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0447811 |
| RUNX1 | runt-related transcription factor 1 | -0.044761 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.043563 |
| NABP1 | nucleic acid binding protein 1 | -0.0428298 |
| ATP13A3 | ATPase type 13A3 | -0.0428067 |
| RPS24 | ribosomal protein S24 | -0.0426727 |
| ANKRD10 | ankyrin repeat domain 10 | -0.041365 |
| UVRAG | UV radiation resistance associated | -0.0400495 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0387884 |
| S100A10 | S100 calcium binding protein A10 | -0.038646 |
| ATG7 | autophagy related 7 | -0.0382657 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0381765 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0377845 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0376151 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0375925 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0370469 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0365422 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0364195 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0361379 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0361299 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0358395 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0357669 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0352709 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0351997 |
| UBC | ubiquitin C | -0.0349043 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.033481 |
| TMEM165 | transmembrane protein 165 | -0.0333744 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.033319 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0324767 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0323657 |
| SEPTIN10 | septin 10 | -0.0322951 |
| LAMB3 | laminin, beta 3 | -0.03208 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0315398 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0306959 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0304583 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0300765 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0300304 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0298437 |
| NGLY1 | N-glycanase 1 | -0.0297945 |
| NF1 | neurofibromin 1 | -0.0297794 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.02975 |
| ENSA | endosulfine alpha | -0.0291787 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0283563 |
| RPL35A | ribosomal protein L35a | -0.0282795 |
| MYO1D | myosin ID | -0.0282166 |
| PYGL | phosphorylase, glycogen, liver | -0.0280259 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0276148 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0275607 |
| RLF | rearranged L-myc fusion | -0.0274571 |
| OSMR | oncostatin M receptor | -0.0270678 |
| USP3 | ubiquitin specific peptidase 3 | -0.0270027 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0269618 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0264029 |
| PTK2 | protein tyrosine kinase 2 | -0.0261082 |
| MT1X | metallothionein 1X | -0.0260637 |
| GM2A | GM2 ganglioside activator | -0.0260516 |
| WASF2 | WAS protein family, member 2 | -0.0259173 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0258357 |
| HMGA1 | high mobility group AT-hook 1 | -0.0257214 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0250227 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0249105 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0247918 |
| CD163L1 | CD163 molecule-like 1 | -0.0247809 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.024521 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0244088 |
| CSTB | cystatin B (stefin B) | -0.0240777 |
