Binimetinib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Binimetinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Binimetinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.120188
ENO1 enolase 1, (alpha) 0.0876895
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0811159
RAD51B RAD51 paralog B 0.0771824
ANKRD28 ankyrin repeat domain 28 0.0759022
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0748644
GPC6 glypican 6 0.0609096
DST dystonin 0.0580037
LOX lysyl oxidase 0.0540191
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.052585
B2M beta-2-microglobulin 0.0521356
IGFBP3 insulin-like growth factor binding protein 3 0.0511443
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.050203
FNDC3B fibronectin type III domain containing 3B 0.0495967
KYNU kynureninase 0.0488411
THBS1 thrombospondin 1 0.0485556
ZEB2 zinc finger E-box binding homeobox 2 0.047638
AOPEP aminopeptidase O (putative) 0.0467696
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0457368
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.045147
FAM20C family with sequence similarity 20, member C 0.0446247
IFI6 interferon, alpha-inducible protein 6 0.0444731
PLIN2 perilipin 2 0.0441293
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0438525
CA12 carbonic anhydrase XII 0.0434378
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0423487
DPYD dihydropyrimidine dehydrogenase 0.0409482
SOD2 superoxide dismutase 2, mitochondrial 0.0401859
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0396976
EXT1 exostosin glycosyltransferase 1 0.0392032
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0391649
RNF213 ring finger protein 213 0.0389233
MAML2 mastermind-like 2 (Drosophila) 0.0388722
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0380092
MBNL1 muscleblind-like splicing regulator 1 0.0375664
C1R complement component 1, r subcomponent 0.0374929
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0371359
MX2 MX dynamin-like GTPase 2 0.0368169
PTPRK protein tyrosine phosphatase, receptor type, K 0.0362238
SQSTM1 sequestosome 1 0.0358935
AKAP12 A kinase (PRKA) anchor protein 12 0.0356617
LRMDA leucine rich melanocyte differentiation associated 0.0355559
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0347081
FTH1 ferritin, heavy polypeptide 1 0.0343097
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0341109
ETV6 ets variant 6 0.0339155
HDAC9 histone deacetylase 9 0.033661
FOS FBJ murine osteosarcoma viral oncogene homolog 0.033381
ZMYND8 zinc finger, MYND-type containing 8 0.033033
TRIO trio Rho guanine nucleotide exchange factor 0.0330178
MX1 MX dynamin-like GTPase 1 0.0329095
IFITM1 interferon induced transmembrane protein 1 0.0326693
ZFP36L1 ZFP36 ring finger protein-like 1 0.0324575
CLIC4 chloride intracellular channel 4 0.032172
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0320154
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0317296
OPTN optineurin 0.0314317
EHBP1 EH domain binding protein 1 0.0303059
HMCN1 hemicentin 1 0.029585
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.029474
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0292566
NTN4 netrin 4 0.0292336
AKAP9 A kinase (PRKA) anchor protein 9 0.0291737
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0290982
RHOBTB3 Rho-related BTB domain containing 3 0.028918
IFI44L interferon-induced protein 44-like 0.0287449
RND3 Rho family GTPase 3 0.0284525
EGR1 early growth response 1 0.0283653
KSR1 kinase suppressor of ras 1 0.0283596
PTPRR protein tyrosine phosphatase, receptor type, R 0.0283207
SAMD9 sterile alpha motif domain containing 9 0.0281729
HEG1 heart development protein with EGF-like domains 1 0.0281578
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0280501
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0280235
RUNX2 runt-related transcription factor 2 0.0273579
PRKCSH protein kinase C substrate 80K-H 0.0272886
RNF24 ring finger protein 24 0.027151
DPYSL3 dihydropyrimidinase-like 3 0.0270666
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0268146
SYAP1 synapse associated protein 1 0.0268035
PGK1 phosphoglycerate kinase 1 0.0263851
JUN jun proto-oncogene 0.0259346
LOC102724023 ES1 protein homolog, mitochondrial 0.0253576
SUMF1 sulfatase modifying factor 1 0.0251127
TNNC1 troponin C type 1 (slow) 0.0250359
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.02494
ADD3 adducin 3 (gamma) 0.0247462
ZNF609 zinc finger protein 609 0.0247381
FAM13A family with sequence similarity 13, member A 0.0246848
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0246328
PALLD palladin, cytoskeletal associated protein 0.0241396
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0239969
RAI14 retinoic acid induced 14 0.0239556
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0235831
MYO1E myosin IE 0.0234756
SKAP2 src kinase associated phosphoprotein 2 0.0234559
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0234434
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.023353
HLA-B major histocompatibility complex, class I, B 0.0233308
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0233205

decreased expression

Symbol Name Standardized Value
SDK1 sidekick cell adhesion molecule 1 -0.181288
CXCL8 chemokine (C-X-C motif) ligand 8 -0.178688
CDH13 cadherin 13 -0.156296
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.12239
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.121705
STC1 stanniocalcin 1 -0.114537
HMGA2 high mobility group AT-hook 2 -0.114346
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.107001
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.10034
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0961967
EFNA5 ephrin-A5 -0.0950557
MTSS1 metastasis suppressor 1 -0.0923732
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0832326
GRB10 growth factor receptor-bound protein 10 -0.0801097
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0797497
ANTXR2 anthrax toxin receptor 2 -0.0782373
TFPI2 tissue factor pathway inhibitor 2 -0.0722855
VIM vimentin -0.0702827
MSRB3 methionine sulfoxide reductase B3 -0.0697574
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0657832
CD44 CD44 molecule (Indian blood group) -0.0653143
MT2A metallothionein 2A -0.0609603
PDE4D phosphodiesterase 4D, cAMP-specific -0.060183
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0591894
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0586913
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0515369
CDCP1 CUB domain containing protein 1 -0.0512906
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0502519
NRP1 neuropilin 1 -0.0494972
NAV2 neuron navigator 2 -0.0480247
AKAP13 A kinase (PRKA) anchor protein 13 -0.0477019
NUMB numb homolog (Drosophila) -0.0458101
FBXL13 F-box and leucine-rich repeat protein 13 -0.0430657
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0425976
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0416894
NHSL1 NHS-like 1 -0.0409883
DNER delta/notch-like EGF repeat containing -0.0395156
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0391475
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0390374
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0366939
NPAS2 neuronal PAS domain protein 2 -0.0357481
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0353888
HPCAL1 hippocalcin-like 1 -0.0345877
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.033699
ATXN1 ataxin 1 -0.0335641
PDIA4 protein disulfide isomerase family A, member 4 -0.0335077
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0332129
DTNA dystrobrevin, alpha -0.0324417
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0319579
NAV3 neuron navigator 3 -0.0319175
PID1 phosphotyrosine interaction domain containing 1 -0.0315041
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0314432
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0313551
RBM39 RNA binding motif protein 39 -0.0310386
BMAL2 basic helix-loop-helix ARNT like 2 -0.0307222
NRG1 neuregulin 1 -0.0306605
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0303761
ANKRD11 ankyrin repeat domain 11 -0.029568
RUNX1 runt-related transcription factor 1 -0.0294131
TOP1 topoisomerase (DNA) I -0.029341
ELL2 elongation factor, RNA polymerase II, 2 -0.029267
CDK14 cyclin-dependent kinase 14 -0.0289214
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0288811
OGA O-GlcNAcase -0.028877
RAP1B RAP1B, member of RAS oncogene family -0.0288019
UBA6 ubiquitin-like modifier activating enzyme 6 -0.028691
BIRC6 baculoviral IAP repeat containing 6 -0.0279073
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0275206
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0274142
SH3RF3 SH3 domain containing ring finger 3 -0.0272702
KDM7A lysine (K)-specific demethylase 7A -0.0272291
ARHGAP5 Rho GTPase activating protein 5 -0.0270962
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0268023
ZFAND3 zinc finger, AN1-type domain 3 -0.0267147
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0262935
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0262275
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0260013
CLMP CXADR-like membrane protein -0.0257374
PCNX1 pecanex 1 -0.0256925
HELZ helicase with zinc finger -0.025483
SNX14 sorting nexin 14 -0.0254624
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0254387
VEGFC vascular endothelial growth factor C -0.0254255
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0254019
NBAS neuroblastoma amplified sequence -0.0253652
RAB1A RAB1A, member RAS oncogene family -0.0253579
EREG epiregulin -0.0251484
ZEB1 zinc finger E-box binding homeobox 1 -0.0246288
SNX9 sorting nexin 9 -0.0246137
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0245375
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0244202
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0243565
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0240922
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0239868
PTK2 protein tyrosine kinase 2 -0.0239861
EEF2 eukaryotic translation elongation factor 2 -0.0239563
TSPAN5 tetraspanin 5 -0.0237582
COG5 component of oligomeric golgi complex 5 -0.0236797
PLAUR plasminogen activator, urokinase receptor -0.0233812
USP3 ubiquitin specific peptidase 3 -0.0231275