| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Binimetinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.247254 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.115283 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.107342 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102437 |
| FGB | fibrinogen beta chain | 0.0997823 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0899389 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0877589 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0868682 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0839952 |
| CALR | calreticulin | 0.0776398 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0738273 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0724186 |
| TXNRD1 | thioredoxin reductase 1 | 0.0721642 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.071968 |
| AHNAK | AHNAK nucleoprotein | 0.0709514 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0703322 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0692174 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0680099 |
| APP | amyloid beta (A4) precursor protein | 0.0655545 |
| FGA | fibrinogen alpha chain | 0.0634179 |
| RPS27A | ribosomal protein S27a | 0.063148 |
| UBC | ubiquitin C | 0.0601715 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0598254 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0579899 |
| GLG1 | golgi glycoprotein 1 | 0.0555409 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0545755 |
| SIK3 | SIK family kinase 3 | 0.0542156 |
| MYOF | myoferlin | 0.0537454 |
| NTN4 | netrin 4 | 0.0532624 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0525791 |
| FGG | fibrinogen gamma chain | 0.0508339 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0508028 |
| ENO1 | enolase 1, (alpha) | 0.0505827 |
| RBM39 | RNA binding motif protein 39 | 0.0499386 |
| ASPH | aspartate beta-hydroxylase | 0.0499187 |
| PCBP2 | poly(rC) binding protein 2 | 0.0496675 |
| HLA-B | major histocompatibility complex, class I, B | 0.048112 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0470459 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0466609 |
| TNPO1 | transportin 1 | 0.0466575 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.046319 |
| VIM | vimentin | 0.0451823 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0451795 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0448315 |
| ANXA1 | annexin A1 | 0.044754 |
| B2M | beta-2-microglobulin | 0.0443753 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0433617 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0423967 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0423477 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0418409 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0416748 |
| LMNA | lamin A/C | 0.0410995 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0404274 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0401139 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0399472 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0396321 |
| WWOX | WW domain containing oxidoreductase | 0.0386465 |
| MT1X | metallothionein 1X | 0.03858 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0381745 |
| RPL23 | ribosomal protein L23 | 0.0368855 |
| TPM3 | tropomyosin 3 | 0.0357324 |
| LAMB1 | laminin, beta 1 | 0.035646 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0354613 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0353997 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0353232 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0348995 |
| RPS3 | ribosomal protein S3 | 0.034598 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0345049 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0337858 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0332828 |
| YAP1 | Yes-associated protein 1 | 0.0330478 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0327394 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0324599 |
| SQSTM1 | sequestosome 1 | 0.0323974 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0323948 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0322946 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.032159 |
| SVIL | supervillin | 0.0320716 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0316141 |
| RPL3 | ribosomal protein L3 | 0.0314796 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0314478 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0312437 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.030783 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0307822 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.030694 |
| ACTG1 | actin gamma 1 | 0.030454 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0302747 |
| KIAA0319 | KIAA0319 | 0.0301178 |
| MATR3 | matrin 3 | 0.0299793 |
| RPL4 | ribosomal protein L4 | 0.0298947 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.029846 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0296261 |
| NNMT | nicotinamide N-methyltransferase | 0.0285096 |
| EFNA5 | ephrin-A5 | 0.0284388 |
| UTRN | utrophin | 0.0283074 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0282518 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0279188 |
| NFIA | nuclear factor I/A | 0.0279087 |
| JUN | jun proto-oncogene | 0.0278705 |
| COPA | coatomer protein complex, subunit alpha | 0.0278112 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.208139 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.125656 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.116239 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.103225 |
| IGF2 | insulin-like growth factor 2 | -0.0937366 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0906692 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0893328 |
| GRAMD1B | GRAM domain containing 1B | -0.0847812 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0836163 |
| MT2A | metallothionein 2A | -0.0819183 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0776142 |
| IER3 | immediate early response 3 | -0.0712481 |
| EGR1 | early growth response 1 | -0.0696967 |
| CMIP | c-Maf inducing protein | -0.0611818 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0604983 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0572057 |
| FMNL2 | formin-like 2 | -0.0544493 |
| PYGL | phosphorylase, glycogen, liver | -0.0491439 |
| STC1 | stanniocalcin 1 | -0.0489781 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0483035 |
| HMGA1 | high mobility group AT-hook 1 | -0.0474538 |
| PFN1 | profilin 1 | -0.0464465 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0453626 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0431501 |
| NAV3 | neuron navigator 3 | -0.0424395 |
| MCL1 | myeloid cell leukemia 1 | -0.0414124 |
| TMSB10 | thymosin beta 10 | -0.0410096 |
| FLNB | filamin B, beta | -0.0408877 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0406447 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0403241 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0370417 |
| RPLP1 | ribosomal protein, large, P1 | -0.0358366 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0353153 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0348803 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0338511 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0333219 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0327142 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.032569 |
| NRG1 | neuregulin 1 | -0.0318278 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0318145 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0313542 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0303814 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0297401 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0288145 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0286829 |
| UPP1 | uridine phosphorylase 1 | -0.0283416 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.028183 |
| CDCP1 | CUB domain containing protein 1 | -0.0279929 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0278854 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0269391 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0265864 |
| S100A11 | S100 calcium binding protein A11 | -0.0256174 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0255978 |
| RPS6 | ribosomal protein S6 | -0.0254387 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0254263 |
| RTN4 | reticulon 4 | -0.0253267 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0251591 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0239756 |
| AK1 | adenylate kinase 1 | -0.0236207 |
| PFDN2 | prefoldin subunit 2 | -0.0235066 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0232497 |
| RPL8 | ribosomal protein L8 | -0.0230544 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0227438 |
| RPL35A | ribosomal protein L35a | -0.0226 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0221629 |
| PKM | pyruvate kinase, muscle | -0.0215767 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0214055 |
| HMOX1 | heme oxygenase 1 | -0.021378 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0213273 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0212511 |
| HMGB1 | high mobility group box 1 | -0.0210946 |
| CCN2 | cellular communication network factor 2 | -0.0210311 |
| FRMD6 | FERM domain containing 6 | -0.0210285 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0209997 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0209386 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0209287 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0207966 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0205131 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.0204604 |
| BMP6 | bone morphogenetic protein 6 | -0.0204477 |
| E2F3 | E2F transcription factor 3 | -0.0202972 |
| PRDX1 | peroxiredoxin 1 | -0.0202584 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0202306 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0199745 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0196125 |
| CHN1 | chimerin 1 | -0.0190836 |
| CD44 | CD44 molecule (Indian blood group) | -0.0188695 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0186883 |
| RPS19 | ribosomal protein S19 | -0.0181428 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0178626 |
| S100A10 | S100 calcium binding protein A10 | -0.0173829 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0173505 |
| INHBA | inhibin, beta A | -0.0172935 |
| RPS20 | ribosomal protein S20 | -0.0172217 |
| FOXN2 | forkhead box N2 | -0.017061 |
| AFTPH | aftiphilin | -0.0169916 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.016901 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0169008 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0166235 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0165299 |
