Binimetinib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Binimetinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Binimetinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.192848
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.126108
PTMA prothymosin, alpha 0.11189
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0965847
TRIO trio Rho guanine nucleotide exchange factor 0.0827185
CANX calnexin 0.0783846
ENO1 enolase 1, (alpha) 0.0768748
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0749558
EEF2 eukaryotic translation elongation factor 2 0.0749105
GOLGA4 golgin A4 0.0738553
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0682661
NAMPT nicotinamide phosphoribosyltransferase 0.0662189
MBNL2 muscleblind-like splicing regulator 2 0.0651309
HELZ helicase with zinc finger 0.0651201
DST dystonin 0.0643986
MYOF myoferlin 0.0641584
PGK1 phosphoglycerate kinase 1 0.0615498
TENM3 teneurin transmembrane protein 3 0.0581698
LIMCH1 LIM and calponin homology domains 1 0.0563757
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0556623
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0546142
MED13 mediator complex subunit 13 0.0535951
SPAG9 sperm associated antigen 9 0.0529347
RPS3 ribosomal protein S3 0.0522858
RAD51B RAD51 paralog B 0.0520379
RABGAP1L RAB GTPase activating protein 1-like 0.0478462
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0477916
FAT1 FAT atypical cadherin 1 0.0477847
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0475447
CSDE1 cold shock domain containing E1, RNA-binding 0.0472769
SLIT2 slit homolog 2 (Drosophila) 0.0467202
PRRC2C proline-rich coiled-coil 2C 0.0466585
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.046567
PDLIM5 PDZ and LIM domain 5 0.0461441
PTK2 protein tyrosine kinase 2 0.0459278
ANXA1 annexin A1 0.044391
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0439313
XPO1 exportin 1 0.0439196
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0438747
EPS8 epidermal growth factor receptor pathway substrate 8 0.0430706
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0425616
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0407776
KMT2C lysine (K)-specific methyltransferase 2C 0.0403498
AGTPBP1 ATP/GTP binding protein 1 0.0401329
ZNF292 zinc finger protein 292 0.0399182
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0398459
MYO10 myosin X 0.0398268
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0397974
COG5 component of oligomeric golgi complex 5 0.0397681
COL5A2 collagen, type V, alpha 2 0.0397575
TM9SF3 transmembrane 9 superfamily member 3 0.0394522
TXNRD1 thioredoxin reductase 1 0.0390924
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0388405
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0388068
RACK1 receptor for activated C kinase 1 0.0387946
PEAK1 pseudopodium-enriched atypical kinase 1 0.0387783
NKTR natural killer cell triggering receptor 0.0386376
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.038335
CLINT1 clathrin interactor 1 0.038319
JAK1 Janus kinase 1 0.038032
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0373308
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0372185
MAP4 microtubule-associated protein 4 0.0369854
MYH9 myosin, heavy chain 9, non-muscle 0.036771
WDR43 WD repeat domain 43 0.0367463
THOC2 THO complex 2 0.0360643
NBEA neurobeachin 0.0357601
PDIA4 protein disulfide isomerase family A, member 4 0.0356321
NKD1 naked cuticle homolog 1 (Drosophila) 0.0355264
EIF4A1 eukaryotic translation initiation factor 4A1 0.035474
TNS3 tensin 3 0.0354532
CCNL1 cyclin L1 0.0354128
RPL7 ribosomal protein L7 0.0353316
IARS1 isoleucyl-tRNA synthetase 1 0.0351816
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0351242
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0349715
AKR1C1 aldo-keto reductase family 1, member C1 0.0347574
SUCO SUN domain containing ossification factor 0.0345463
EIF4A2 eukaryotic translation initiation factor 4A2 0.0345301
CLTC clathrin, heavy chain (Hc) 0.0342214
RPL26 ribosomal protein L26 0.0342022
PELI1 pellino E3 ubiquitin protein ligase 1 0.03411
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0337121
CALR calreticulin 0.0332232
PTGES2 prostaglandin E synthase 2 0.032379
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0323091
SND1 staphylococcal nuclease and tudor domain containing 1 0.0321857
KDM4C lysine (K)-specific demethylase 4C 0.0319797
RPS4X ribosomal protein S4, X-linked 0.0315672
PIBF1 progesterone immunomodulatory binding factor 1 0.0315467
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0313248
PUM1 pumilio RNA-binding family member 1 0.0311024
GPHN gephyrin 0.0310403
PDIA6 protein disulfide isomerase family A, member 6 0.0305504
PHF21A PHD finger protein 21A 0.0304619
VCL vinculin 0.0303984
ANKRD28 ankyrin repeat domain 28 0.0301882
ADD3 adducin 3 (gamma) 0.0301218
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0291813
ZSWIM6 zinc finger, SWIM-type containing 6 0.0291684

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.163003
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.14064
GRB10 growth factor receptor-bound protein 10 -0.130618
BACE2 beta-site APP-cleaving enzyme 2 -0.13047
CEMIP cell migration inducing protein, hyaluronan binding -0.111392
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.109723
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.104932
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.100202
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0982703
ATOSA atos homolog A -0.0930273
LAMB3 laminin, beta 3 -0.0890849
S100A9 S100 calcium binding protein A9 -0.0837111
MT2A metallothionein 2A -0.0787082
TMSB10 thymosin beta 10 -0.0775864
SVIL supervillin -0.0749367
MYO1E myosin IE -0.0696989
FLNB filamin B, beta -0.0689535
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0683246
MUC16 mucin 16, cell surface associated -0.0681164
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0663382
MACF1 microtubule-actin crosslinking factor 1 -0.0658181
ZMYND8 zinc finger, MYND-type containing 8 -0.0653051
AKAP13 A kinase (PRKA) anchor protein 13 -0.064972
STC1 stanniocalcin 1 -0.0639785
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0638202
NT5C2 5'-nucleotidase, cytosolic II -0.0637981
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0623536
FNDC3B fibronectin type III domain containing 3B -0.061279
PARD3 par-3 family cell polarity regulator -0.0611431
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0593829
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0591127
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0588206
MAML3 mastermind-like 3 (Drosophila) -0.0572299
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0565634
BTG1 B-cell translocation gene 1, anti-proliferative -0.0546264
MCL1 myeloid cell leukemia 1 -0.054031
FBF1 Fas (TNFRSF6) binding factor 1 -0.0538355
CMIP c-Maf inducing protein -0.0532266
ABHD17C abhydrolase domain containing 17C -0.0523663
FN1 fibronectin 1 -0.0516503
AGO2 argonaute RISC catalytic component 2 -0.0485684
KYNU kynureninase -0.0470738
SNX14 sorting nexin 14 -0.046635
SAMD4A sterile alpha motif domain containing 4A -0.0462691
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0462637
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0462511
EGR1 early growth response 1 -0.0460021
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0459377
JMJD1C jumonji domain containing 1C -0.0455668
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0454292
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0448151
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0445082
TM4SF1 transmembrane 4 L six family member 1 -0.0433658
ZNF638 zinc finger protein 638 -0.0432758
LAMC2 laminin, gamma 2 -0.0428889
KDM7A lysine (K)-specific demethylase 7A -0.0425833
RAB10 RAB10, member RAS oncogene family -0.0423272
SLMAP sarcolemma associated protein -0.0421275
DOCK4 dedicator of cytokinesis 4 -0.0417453
BMAL2 basic helix-loop-helix ARNT like 2 -0.0415805
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0415434
F3 coagulation factor III (thromboplastin, tissue factor) -0.0414853
EZR ezrin -0.0413954
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0400696
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0398926
KIF13B kinesin family member 13B -0.0395758
ANTXR2 anthrax toxin receptor 2 -0.0391637
RPL9 ribosomal protein L9 -0.0388632
RBM47 RNA binding motif protein 47 -0.038845
CCND1 cyclin D1 -0.0387282
FBXO11 F-box protein 11 -0.0385478
THSD4 thrombospondin, type I, domain containing 4 -0.0383093
PTPRM protein tyrosine phosphatase, receptor type, M -0.037996
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0373183
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.036561
DLG1 discs, large homolog 1 (Drosophila) -0.0363472
GLIS3 GLIS family zinc finger 3 -0.0361082
ERBIN erbb2 interacting protein -0.035872
RAI14 retinoic acid induced 14 -0.0354454
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0353399
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0353125
S100A11 S100 calcium binding protein A11 -0.0348954
CD2AP CD2-associated protein -0.0340933
RIOK3 RIO kinase 3 -0.0339237
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.033899
AKAP12 A kinase (PRKA) anchor protein 12 -0.0338281
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0337668
RPS16 ribosomal protein S16 -0.0337083
BZW1 basic leucine zipper and W2 domains 1 -0.0336466
ITGB4 integrin, beta 4 -0.0335861
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0331424
DOCK5 dedicator of cytokinesis 5 -0.0329394
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0328894
SNX9 sorting nexin 9 -0.032765
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0326131
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0319415
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0318648
TPM4 tropomyosin 4 -0.0318387
STRN3 striatin, calmodulin binding protein 3 -0.0315127
HMGA2 high mobility group AT-hook 2 -0.0314468