| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.158881 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.138155 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.11778 |
| GRAMD1B | GRAM domain containing 1B | 0.112575 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.110103 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.109878 |
| PDE10A | phosphodiesterase 10A | 0.108829 |
| ENO1 | enolase 1, (alpha) | 0.0967686 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.095864 |
| YBX3 | Y box binding protein 3 | 0.093523 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0891453 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.083787 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0765396 |
| ADAR | adenosine deaminase, RNA-specific | 0.0729 |
| PCBP2 | poly(rC) binding protein 2 | 0.0711901 |
| RAD51B | RAD51 paralog B | 0.0703593 |
| TPM3 | tropomyosin 3 | 0.0695072 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0623126 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0620373 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0569678 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0569335 |
| CCNL1 | cyclin L1 | 0.0555002 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0554686 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0552839 |
| LATS2 | large tumor suppressor kinase 2 | 0.053133 |
| WWOX | WW domain containing oxidoreductase | 0.0530943 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0507083 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0501977 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0498204 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0486881 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0482387 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0472475 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0458751 |
| RPL3 | ribosomal protein L3 | 0.0446258 |
| PLS3 | plastin 3 | 0.043651 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0426695 |
| YAP1 | Yes-associated protein 1 | 0.0426384 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.042458 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0424377 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.041898 |
| OGA | O-GlcNAcase | 0.0413372 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0410501 |
| DENND5B | DENN/MADD domain containing 5B | 0.040905 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0402562 |
| RNF213 | ring finger protein 213 | 0.0388465 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0387338 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0384141 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0383967 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0382869 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0382705 |
| VMP1 | vacuole membrane protein 1 | 0.0381829 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0375493 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0375432 |
| TLN1 | talin 1 | 0.0375419 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0372772 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0365315 |
| XPO1 | exportin 1 | 0.0360809 |
| PTMA | prothymosin, alpha | 0.0356034 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0350389 |
| RNF145 | ring finger protein 145 | 0.035031 |
| SET | SET nuclear proto-oncogene | 0.0348083 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0345903 |
| DSPP | dentin sialophosphoprotein | 0.0344809 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0341696 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.034076 |
| MACROD2 | MACRO domain containing 2 | 0.0337459 |
| MED13L | mediator complex subunit 13-like | 0.0334998 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.033454 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0329636 |
| COPA | coatomer protein complex, subunit alpha | 0.032616 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0325985 |
| CEP250 | centrosomal protein 250kDa | 0.0324018 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0322685 |
| VCL | vinculin | 0.0321622 |
| ATP11A | ATPase, class VI, type 11A | 0.0319278 |
| PTEN | phosphatase and tensin homolog | 0.0317631 |
| PRELID2 | PRELI domain containing 2 | 0.0312795 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.030839 |
| BMP5 | bone morphogenetic protein 5 | 0.0306702 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 0.0304807 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0297515 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0297426 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0297246 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0294938 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0288142 |
| FOXP1 | forkhead box P1 | 0.0287241 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0286482 |
| GOLGB1 | golgin B1 | 0.0285633 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.02835 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0283286 |
| NRDC | nardilysin convertase | 0.028294 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0282708 |
| POTEF | POTE ankyrin domain family, member F | 0.0280386 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0278825 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0276917 |
| PGK1 | phosphoglycerate kinase 1 | 0.027572 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0273626 |
| RPS3 | ribosomal protein S3 | 0.0273518 |
| TCIM | transcriptional and immune response regulator | 0.0272551 |
| COL5A2 | collagen, type V, alpha 2 | 0.0271701 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.250628 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.172289 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.168876 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.108461 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0977113 |
| HMGA2 | high mobility group AT-hook 2 | -0.0716276 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0680006 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0634838 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0632115 |
| EGR1 | early growth response 1 | -0.0616416 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0529389 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0527333 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0519798 |
| TMSB10 | thymosin beta 10 | -0.0440085 |
| RPL35A | ribosomal protein L35a | -0.0414152 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0406774 |
| VIM | vimentin | -0.0403891 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0394483 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0365767 |
| NABP1 | nucleic acid binding protein 1 | -0.0363534 |
| FMNL2 | formin-like 2 | -0.0363315 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0349708 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0348888 |
| EGFR | epidermal growth factor receptor | -0.0347265 |
| CDK17 | cyclin-dependent kinase 17 | -0.034123 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0327244 |
| RPS24 | ribosomal protein S24 | -0.032304 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0318654 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0305458 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0301774 |
| INTS6 | integrator complex subunit 6 | -0.0301604 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0299752 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0296777 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0289469 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0287863 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.028039 |
| HMGA1 | high mobility group AT-hook 1 | -0.0273558 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0271302 |
| RPLP0 | ribosomal protein, large, P0 | -0.0269511 |
| RPS15 | ribosomal protein S15 | -0.0264873 |
| RYR3 | ryanodine receptor 3 | -0.0264231 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0262069 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0254559 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0254009 |
| SNX14 | sorting nexin 14 | -0.0248652 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0247331 |
| RPL38 | ribosomal protein L38 | -0.0245726 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.024277 |
| IGF2 | insulin-like growth factor 2 | -0.0241498 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0241345 |
| RPS21 | ribosomal protein S21 | -0.0237787 |
| TUBA1C | tubulin, alpha 1c | -0.0235503 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0231813 |
| TAOK1 | TAO kinase 1 | -0.0227598 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0225979 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0223881 |
| CD44 | CD44 molecule (Indian blood group) | -0.0223223 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0223176 |
| RPL32 | ribosomal protein L32 | -0.0222915 |
| ACTN1 | actinin, alpha 1 | -0.0219922 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0219863 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0219764 |
| S100A11 | S100 calcium binding protein A11 | -0.0218606 |
| SRP72 | signal recognition particle 72kDa | -0.021622 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0214839 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0214722 |
| ARF1 | ADP-ribosylation factor 1 | -0.0213258 |
| RPS16 | ribosomal protein S16 | -0.0209446 |
| TOP1 | topoisomerase (DNA) I | -0.0207808 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0207679 |
| SRPK1 | SRSF protein kinase 1 | -0.0206333 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0205849 |
| GLO1 | glyoxalase I | -0.0204354 |
| RPS29 | ribosomal protein S29 | -0.0201597 |
| E2F3 | E2F transcription factor 3 | -0.0198468 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0198065 |
| STK4 | serine/threonine kinase 4 | -0.0197976 |
| FTL | ferritin, light polypeptide | -0.0197767 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0196247 |
| PXDN | peroxidasin | -0.0195288 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0191376 |
| ZNF800 | zinc finger protein 800 | -0.0190586 |
| MYO9B | myosin IXB | -0.0190035 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0189131 |
| RPS25 | ribosomal protein S25 | -0.0187991 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0186634 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0183691 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0182353 |
| KRT18 | keratin 18, type I | -0.018185 |
| ATG7 | autophagy related 7 | -0.0180806 |
| STC1 | stanniocalcin 1 | -0.0179949 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0179795 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0177514 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0176607 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0176224 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0172137 |
| CDCP1 | CUB domain containing protein 1 | -0.0170958 |
| RAN | RAN, member RAS oncogene family | -0.0170005 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0168524 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0168336 |
