| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Binimetinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.156534 |
| FN1 | fibronectin 1 | 0.152554 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.105172 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0937233 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0858373 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0828662 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0806449 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0784213 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0724134 |
| POTEF | POTE ankyrin domain family, member F | 0.0723144 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0721055 |
| TXNIP | thioredoxin interacting protein | 0.0718001 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.069002 |
| ADAR | adenosine deaminase, RNA-specific | 0.0671844 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0658169 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0645558 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0640429 |
| CCNL1 | cyclin L1 | 0.0617612 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0592874 |
| PCBP2 | poly(rC) binding protein 2 | 0.0579257 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0572946 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0558572 |
| MYOF | myoferlin | 0.0556758 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0554034 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0522971 |
| RPL23 | ribosomal protein L23 | 0.0518132 |
| GOLGA4 | golgin A4 | 0.0515662 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0508593 |
| CD46 | CD46 molecule, complement regulatory protein | 0.049975 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0496168 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0487119 |
| OCLN | occludin | 0.0477792 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.047752 |
| TUFT1 | tuftelin 1 | 0.047283 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0461225 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0459775 |
| RPL4 | ribosomal protein L4 | 0.04595 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0458789 |
| ZNF148 | zinc finger protein 148 | 0.0452023 |
| RUNX1 | runt-related transcription factor 1 | 0.0451655 |
| S100A6 | S100 calcium binding protein A6 | 0.0448489 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0446091 |
| HMGB2 | high mobility group box 2 | 0.0434115 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0429507 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0425113 |
| RPL3 | ribosomal protein L3 | 0.0423092 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0416791 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0414117 |
| ERBIN | erbb2 interacting protein | 0.0413692 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0404737 |
| PTEN | phosphatase and tensin homolog | 0.0397083 |
| PALLD | palladin, cytoskeletal associated protein | 0.0392406 |
| HELZ | helicase with zinc finger | 0.0391298 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0390425 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0381183 |
| VCL | vinculin | 0.0380933 |
| TMEM131L | transmembrane 131 like | 0.0380431 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0380102 |
| LDHA | lactate dehydrogenase A | 0.0377078 |
| SGMS2 | sphingomyelin synthase 2 | 0.0375183 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0374976 |
| VMP1 | vacuole membrane protein 1 | 0.0362178 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0360654 |
| YBX1 | Y box binding protein 1 | 0.0358161 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.035524 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0353242 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0343623 |
| FHIT | fragile histidine triad | 0.0343347 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0343256 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0338904 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0337472 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0336247 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0336143 |
| NEK7 | NIMA-related kinase 7 | 0.0334782 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0334703 |
| DSPP | dentin sialophosphoprotein | 0.0332442 |
| NPTN | neuroplastin | 0.0322392 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0322306 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0316912 |
| RPS12 | ribosomal protein S12 | 0.0315987 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0313735 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0312791 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0307641 |
| STK24 | serine/threonine kinase 24 | 0.0307237 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0305334 |
| NDRG1 | N-myc downstream regulated 1 | 0.0304667 |
| ETV6 | ets variant 6 | 0.0302348 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0302238 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0302141 |
| YAP1 | Yes-associated protein 1 | 0.0298994 |
| GPD2 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.0298987 |
| FLNB | filamin B, beta | 0.0296106 |
| MSMO1 | methylsterol monooxygenase 1 | 0.029377 |
| ITGAV | integrin, alpha V | 0.0293656 |
| SEPTIN11 | septin 11 | 0.0293177 |
| RPLP0 | ribosomal protein, large, P0 | 0.0292704 |
| PCM1 | pericentriolar material 1 | 0.0288523 |
| IL6ST | interleukin 6 signal transducer | 0.028795 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0285436 |
| SMYD3 | SET and MYND domain containing 3 | 0.0284309 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.180689 |
| GRB10 | growth factor receptor-bound protein 10 | -0.141052 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.137783 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.119058 |
| TOP1 | topoisomerase (DNA) I | -0.106668 |
| FTL | ferritin, light polypeptide | -0.105166 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.101388 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100718 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0999866 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0905512 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0870051 |
| TMSB10 | thymosin beta 10 | -0.0836394 |
| LMO7 | LIM domain 7 | -0.0770732 |
| CCND1 | cyclin D1 | -0.0690608 |
| UBC | ubiquitin C | -0.0650411 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0622472 |
| MXD1 | MAX dimerization protein 1 | -0.054063 |
| PGK1 | phosphoglycerate kinase 1 | -0.0499116 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0497903 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.049665 |
| TPM4 | tropomyosin 4 | -0.0473177 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0463734 |
| S100A10 | S100 calcium binding protein A10 | -0.0456039 |
| HMGA1 | high mobility group AT-hook 1 | -0.044786 |
| CDCP1 | CUB domain containing protein 1 | -0.0437824 |
| FAM107B | family with sequence similarity 107, member B | -0.0428479 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0405341 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0404876 |
| G0S2 | G0/G1 switch 2 | -0.0401628 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0399377 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0396335 |
| FAM3C | family with sequence similarity 3, member C | -0.0395193 |
| CSTB | cystatin B (stefin B) | -0.0392554 |
| USP3 | ubiquitin specific peptidase 3 | -0.0382703 |
| RPS29 | ribosomal protein S29 | -0.0369723 |
| HLA-B | major histocompatibility complex, class I, B | -0.0369346 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0369299 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0354224 |
| LAMC2 | laminin, gamma 2 | -0.0344318 |
| DUSP6 | dual specificity phosphatase 6 | -0.0342439 |
| MSI2 | musashi RNA-binding protein 2 | -0.0341985 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0337473 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0331884 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0331857 |
| FOSL1 | FOS-like antigen 1 | -0.0331347 |
| UPP1 | uridine phosphorylase 1 | -0.0322533 |
| HLA-A | major histocompatibility complex, class I, A | -0.0318297 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0315751 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0315582 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0313067 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.0305999 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0298857 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.029848 |
| ARF1 | ADP-ribosylation factor 1 | -0.0297879 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0296277 |
| H1-0 | H1.0 linker histone | -0.0294953 |
| PLAU | plasminogen activator, urokinase | -0.0291661 |
| TP53BP2 | tumor protein p53 binding protein 2 | -0.0288912 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.028813 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0282275 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.0281664 |
| VIM | vimentin | -0.0280971 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.02748 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0273748 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0271473 |
| TMEM165 | transmembrane protein 165 | -0.0268355 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0267599 |
| AREG | amphiregulin | -0.026747 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0259368 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0255142 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.0252903 |
| RAI14 | retinoic acid induced 14 | -0.0252852 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0249447 |
| F11R | F11 receptor | -0.0238989 |
| WASF2 | WAS protein family, member 2 | -0.023472 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0234489 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0233846 |
| NUP58 | nucleoporin 58 | -0.0232901 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0232596 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0230818 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0230455 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0229336 |
| LAMB3 | laminin, beta 3 | -0.0227593 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0224016 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0223966 |
| ETV5 | ets variant 5 | -0.0223811 |
| RPS27A | ribosomal protein S27a | -0.0222373 |
| LMNA | lamin A/C | -0.0219973 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0219964 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0217904 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0217345 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0217317 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0216944 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0216843 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.021633 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0213708 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0213484 |
| RIOK3 | RIO kinase 3 | -0.0213416 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0212665 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0210423 |
