| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.278322 |
| COL5A2 | collagen, type V, alpha 2 | 0.190284 |
| FN1 | fibronectin 1 | 0.190283 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.140358 |
| KYNU | kynureninase | 0.137305 |
| MYOF | myoferlin | 0.131293 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.120857 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.119516 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.112662 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0741618 |
| DST | dystonin | 0.0719192 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0708538 |
| PTEN | phosphatase and tensin homolog | 0.0707707 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0697612 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0653936 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0649675 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0643756 |
| CD109 | CD109 molecule | 0.0591663 |
| CANX | calnexin | 0.0572362 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0562794 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0556351 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0539766 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0524055 |
| PDE10A | phosphodiesterase 10A | 0.0504892 |
| EZR | ezrin | 0.0501726 |
| PCBP2 | poly(rC) binding protein 2 | 0.0499938 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0496124 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0486219 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0464985 |
| XYLT1 | xylosyltransferase I | 0.0455061 |
| ENO1 | enolase 1, (alpha) | 0.0453974 |
| TBXT | T-box transcription factor T | 0.0446222 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0446194 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0443934 |
| MAP7 | microtubule-associated protein 7 | 0.0419977 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0404739 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0397218 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0396114 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0394018 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.039368 |
| TXNRD1 | thioredoxin reductase 1 | 0.0388285 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0384132 |
| NEK7 | NIMA-related kinase 7 | 0.0381285 |
| IL6 | interleukin 6 | 0.0379418 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0373145 |
| LAMA1 | laminin, alpha 1 | 0.0356658 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0356036 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0351954 |
| ANXA1 | annexin A1 | 0.0350545 |
| ATAD1 | ATPase family, AAA domain containing 1 | 0.0346855 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0341016 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0333776 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.03335 |
| OLFML2A | olfactomedin-like 2A | 0.0333157 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0332406 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0317227 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0316124 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0312587 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.031151 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0309545 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0295537 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0294471 |
| RPL3 | ribosomal protein L3 | 0.0293532 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | 0.0292598 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0290932 |
| CALR | calreticulin | 0.0286366 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0285092 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0280043 |
| COPA | coatomer protein complex, subunit alpha | 0.02767 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0276353 |
| EPHA5 | EPH receptor A5 | 0.0269954 |
| NTN4 | netrin 4 | 0.0269624 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0269616 |
| CHL1 | cell adhesion molecule L1-like | 0.0269164 |
| PCDH15 | protocadherin-related 15 | 0.0267185 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0265078 |
| TXNIP | thioredoxin interacting protein | 0.0262859 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0262235 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0260282 |
| SMYD3 | SET and MYND domain containing 3 | 0.0258575 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0256886 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.0256513 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0255451 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0253997 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0253903 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0253131 |
| PALLD | palladin, cytoskeletal associated protein | 0.0251128 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0245069 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0240345 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0238956 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0237995 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0237004 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0236159 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0229707 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 0.0229307 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.022885 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0225468 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.022539 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0222723 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0222655 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.222269 |
| NRCAM | neuronal cell adhesion molecule | -0.167753 |
| EFNA5 | ephrin-A5 | -0.163815 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.131722 |
| DOCK4 | dedicator of cytokinesis 4 | -0.113421 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.111282 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.111147 |
| CDH13 | cadherin 13 | -0.109386 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0998401 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0924553 |
| PCBP3 | poly(rC) binding protein 3 | -0.0773051 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0759409 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0731436 |
| TMSB10 | thymosin beta 10 | -0.0729829 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0713397 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0711742 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.067599 |
| GRAMD1B | GRAM domain containing 1B | -0.0648894 |
| NPAS2 | neuronal PAS domain protein 2 | -0.06314 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.058941 |
| RTN1 | reticulon 1 | -0.0565001 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0549897 |
| GLIS3 | GLIS family zinc finger 3 | -0.054624 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0536416 |
| RPS24 | ribosomal protein S24 | -0.050442 |
| CREB5 | cAMP responsive element binding protein 5 | -0.047143 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0467507 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0455113 |
| RPLP1 | ribosomal protein, large, P1 | -0.0448553 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0446471 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0425362 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0421879 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0416062 |
| RPS6 | ribosomal protein S6 | -0.0403387 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0400241 |
| STC1 | stanniocalcin 1 | -0.0394804 |
| RPL26 | ribosomal protein L26 | -0.0390729 |
| NCKAP5 | NCK-associated protein 5 | -0.0389584 |
| RPL35A | ribosomal protein L35a | -0.0381491 |
| VIM | vimentin | -0.0359525 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0343127 |
| RPL12 | ribosomal protein L12 | -0.0342225 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0336537 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0329408 |
| NHSL1 | NHS-like 1 | -0.0326831 |
| RPL34 | ribosomal protein L34 | -0.0323473 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0321614 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0313852 |
| FRMD4B | FERM domain containing 4B | -0.0301031 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.0297662 |
| RPS21 | ribosomal protein S21 | -0.0296493 |
| RGS2 | regulator of G-protein signaling 2 | -0.02913 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0288574 |
| EPHA4 | EPH receptor A4 | -0.0284528 |
| RPL9 | ribosomal protein L9 | -0.026855 |
| GDA | guanine deaminase | -0.0266719 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0262987 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0257591 |
| RPS8 | ribosomal protein S8 | -0.0253952 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0253185 |
| RPS19 | ribosomal protein S19 | -0.0251847 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0250342 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0249439 |
| LSAMP | limbic system-associated membrane protein | -0.0245528 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0243995 |
| CDK17 | cyclin-dependent kinase 17 | -0.0239269 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0237542 |
| RPL19 | ribosomal protein L19 | -0.0235188 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0219921 |
| RPLP0 | ribosomal protein, large, P0 | -0.0219132 |
| RPS4X | ribosomal protein S4, X-linked | -0.0218925 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.02171 |
| RPL38 | ribosomal protein L38 | -0.0213055 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0210937 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0209676 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0208939 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0206617 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0205199 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0201055 |
| S100A10 | S100 calcium binding protein A10 | -0.0198769 |
| LAMB1 | laminin, beta 1 | -0.0198111 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0194997 |
| RPL11 | ribosomal protein L11 | -0.0194042 |
| RPL32 | ribosomal protein L32 | -0.0193812 |
| SRGN | serglycin | -0.0192525 |
| GPRIN3 | GPRIN family member 3 | -0.0192128 |
| HMGB1 | high mobility group box 1 | -0.0190725 |
| MTAP | methylthioadenosine phosphorylase | -0.019055 |
| CD44 | CD44 molecule (Indian blood group) | -0.0190341 |
| ITGB5 | integrin, beta 5 | -0.0189244 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0188417 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0188108 |
| UNC5D | unc-5 homolog D (C. elegans) | -0.0185938 |
| RPS28 | ribosomal protein S28 | -0.01847 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0183978 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0182216 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0181261 |
| PLAUR | plasminogen activator, urokinase receptor | -0.017903 |
| RPLP2 | ribosomal protein, large, P2 | -0.0178686 |
| RPL35 | ribosomal protein L35 | -0.0178651 |
