| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Binimetinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.157558 |
| DSPP | dentin sialophosphoprotein | 0.126104 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.122018 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.121272 |
| POTEF | POTE ankyrin domain family, member F | 0.109945 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.109769 |
| DSCAM | Down syndrome cell adhesion molecule | 0.106381 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.104637 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.104083 |
| COL1A2 | collagen, type I, alpha 2 | 0.0982393 |
| PRELID2 | PRELI domain containing 2 | 0.0971735 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0925095 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0906629 |
| INHBA | inhibin, beta A | 0.0901181 |
| TNS3 | tensin 3 | 0.0872801 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0772576 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0763232 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0754137 |
| FNIP1 | folliculin interacting protein 1 | 0.0741727 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0735011 |
| ENO1 | enolase 1, (alpha) | 0.0707479 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0702528 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0696396 |
| PTEN | phosphatase and tensin homolog | 0.0693132 |
| TXNRD1 | thioredoxin reductase 1 | 0.0688119 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0666787 |
| PCBP2 | poly(rC) binding protein 2 | 0.0662551 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0661968 |
| YBX1 | Y box binding protein 1 | 0.0639674 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0635284 |
| CAVIN1 | caveolae associated protein 1 | 0.062908 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0600011 |
| ZNF292 | zinc finger protein 292 | 0.0596692 |
| WAC | WW domain containing adaptor with coiled-coil | 0.057454 |
| VEGFA | vascular endothelial growth factor A | 0.0565554 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0562871 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.056013 |
| CALR | calreticulin | 0.0549728 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0547724 |
| RNF213 | ring finger protein 213 | 0.054574 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0545181 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0542903 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0536067 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.052095 |
| JMJD1C | jumonji domain containing 1C | 0.0510503 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0510413 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0507843 |
| RPS3 | ribosomal protein S3 | 0.0491342 |
| RPS12 | ribosomal protein S12 | 0.0489632 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0485843 |
| USP34 | ubiquitin specific peptidase 34 | 0.0481338 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0465972 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0450535 |
| PTK2 | protein tyrosine kinase 2 | 0.0450212 |
| RUNX1 | runt-related transcription factor 1 | 0.0448189 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0447172 |
| RBM15 | RNA binding motif protein 15 | 0.0442968 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0437517 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.043488 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0429357 |
| COL5A2 | collagen, type V, alpha 2 | 0.0427345 |
| SBF2 | SET binding factor 2 | 0.0414604 |
| RPS27A | ribosomal protein S27a | 0.0413644 |
| LMNA | lamin A/C | 0.0412343 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0402674 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0397632 |
| EHBP1 | EH domain binding protein 1 | 0.0396657 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0394215 |
| SP100 | SP100 nuclear antigen | 0.0391725 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0389674 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.038928 |
| STAG2 | stromal antigen 2 | 0.0383251 |
| GOLGB1 | golgin B1 | 0.0379412 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0378059 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.037685 |
| EXOC4 | exocyst complex component 4 | 0.0372301 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0370848 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0359647 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0355289 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0352631 |
| CALU | calumenin | 0.0349228 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0346025 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0345838 |
| MYO1E | myosin IE | 0.0343966 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0340087 |
| LMO7 | LIM domain 7 | 0.033689 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0332601 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0329817 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0323231 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0321452 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0316329 |
| SPAG9 | sperm associated antigen 9 | 0.0315608 |
| EZR | ezrin | 0.031047 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0305529 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0303812 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0297372 |
| RPLP0 | ribosomal protein, large, P0 | 0.0296738 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0295077 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.02945 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | 0.0294095 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.210533 |
| NAV2 | neuron navigator 2 | -0.112451 |
| EFNA5 | ephrin-A5 | -0.109404 |
| EXT1 | exostosin glycosyltransferase 1 | -0.109332 |
| DST | dystonin | -0.106236 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.099781 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0966798 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0947955 |
| MT2A | metallothionein 2A | -0.0909594 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0885461 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0851726 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0849393 |
| PDE10A | phosphodiesterase 10A | -0.0844206 |
| CDH13 | cadherin 13 | -0.0834099 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0812102 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0807265 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0779252 |
| VMP1 | vacuole membrane protein 1 | -0.0704918 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0698949 |
| MCL1 | myeloid cell leukemia 1 | -0.0674634 |
| CANX | calnexin | -0.0659289 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0640945 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0612392 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0609566 |
| EGR1 | early growth response 1 | -0.0607081 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0556978 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0556027 |
| OGA | O-GlcNAcase | -0.0545407 |
| RPLP1 | ribosomal protein, large, P1 | -0.0538055 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0531177 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0524226 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0518124 |
| PRKCA | protein kinase C, alpha | -0.0513026 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0512491 |
| VCL | vinculin | -0.0512357 |
| FLNB | filamin B, beta | -0.0508709 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0508578 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0505794 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0504352 |
| DIAPH2 | diaphanous-related formin 2 | -0.0499729 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0490457 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0485179 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0484276 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0483896 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0477943 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0469726 |
| HMGA2 | high mobility group AT-hook 2 | -0.0468608 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0462856 |
| GPC6 | glypican 6 | -0.0459302 |
| B2M | beta-2-microglobulin | -0.0447325 |
| HELZ | helicase with zinc finger | -0.0447216 |
| NHSL1 | NHS-like 1 | -0.044666 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0444098 |
| FN1 | fibronectin 1 | -0.0444008 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0437905 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0432412 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0431999 |
| LAMB3 | laminin, beta 3 | -0.0429454 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.041994 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0414052 |
| DTNA | dystrobrevin, alpha | -0.0403913 |
| CCNI | cyclin I | -0.0402 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0390465 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0382387 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0380273 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0372862 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0372788 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0371338 |
| RBM25 | RNA binding motif protein 25 | -0.0367646 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0363795 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0353986 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0352908 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0351635 |
| RPL19 | ribosomal protein L19 | -0.0349986 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0348953 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0348198 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0342295 |
| PHF21A | PHD finger protein 21A | -0.0339419 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0338726 |
| SMYD3 | SET and MYND domain containing 3 | -0.0330696 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0324202 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0321121 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0317748 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0316496 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0316189 |
| RPL35A | ribosomal protein L35a | -0.0311681 |
| RORA | RAR-related orphan receptor A | -0.0310483 |
| EGFR | epidermal growth factor receptor | -0.0308711 |
| RTN4 | reticulon 4 | -0.0301593 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.030114 |
| FTL | ferritin, light polypeptide | -0.0301049 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.029198 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0290296 |
| ACTG1 | actin gamma 1 | -0.0285511 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0282476 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0278626 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0278585 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0278266 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.027417 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0273943 |
