Binimetinib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Binimetinib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Binimetinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
THBS1 thrombospondin 1 0.174494
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.163857
COL11A1 collagen, type XI, alpha 1 0.128477
PABPC1 poly(A) binding protein, cytoplasmic 1 0.12824
NTM neurotrimin 0.107397
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.103156
PTMA prothymosin, alpha 0.094197
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0759294
ENO1 enolase 1, (alpha) 0.0739897
APP amyloid beta (A4) precursor protein 0.0725518
EEF2 eukaryotic translation elongation factor 2 0.0709739
COL3A1 collagen, type III, alpha 1 0.0693032
POTEF POTE ankyrin domain family, member F 0.0687949
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0664101
FN1 fibronectin 1 0.0647516
ACTG1 actin gamma 1 0.0639153
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0605878
CALR calreticulin 0.060116
UBC ubiquitin C 0.0598236
ANXA2 annexin A2 0.0593026
AHNAK AHNAK nucleoprotein 0.0584214
PDIA6 protein disulfide isomerase family A, member 6 0.0553795
TMSB4X thymosin beta 4, X-linked 0.0553085
PDIA4 protein disulfide isomerase family A, member 4 0.0520115
ITGAV integrin, alpha V 0.0520041
DSCAM Down syndrome cell adhesion molecule 0.0513854
VIM vimentin 0.0511753
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.049877
HDAC9 histone deacetylase 9 0.0492917
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0487658
COL5A2 collagen, type V, alpha 2 0.0479081
PCBP2 poly(rC) binding protein 2 0.0469854
YAP1 Yes-associated protein 1 0.0466369
PCDH18 protocadherin 18 0.0464085
NAP1L1 nucleosome assembly protein 1-like 1 0.0463323
LDHA lactate dehydrogenase A 0.0457263
SET SET nuclear proto-oncogene 0.045205
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0447321
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0443277
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0433219
PEG10 paternally expressed 10 0.0430781
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.040999
TTC3 tetratricopeptide repeat domain 3 0.040634
CSDE1 cold shock domain containing E1, RNA-binding 0.0400116
DST dystonin 0.0399603
MATR3 matrin 3 0.0384329
SFRP4 secreted frizzled-related protein 4 0.0384227
SPAG9 sperm associated antigen 9 0.037866
NCKAP1 NCK-associated protein 1 0.037607
CALU calumenin 0.0375238
COPB1 coatomer protein complex, subunit beta 1 0.0368729
RPS3 ribosomal protein S3 0.036355
MYH9 myosin, heavy chain 9, non-muscle 0.0363506
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0361644
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0361571
TFRC transferrin receptor 0.0360253
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0356069
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0355948
RPS12 ribosomal protein S12 0.0355884
ANXA1 annexin A1 0.0351095
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.034744
PDCD5 programmed cell death 5 0.034569
APLP2 amyloid beta (A4) precursor-like protein 2 0.0344141
RPS27A ribosomal protein S27a 0.0342054
PDIA3 protein disulfide isomerase family A, member 3 0.0336902
SCAF8 SR-related CTD-associated factor 8 0.0330378
SFPQ splicing factor proline/glutamine-rich 0.0325682
STAG2 stromal antigen 2 0.0325668
EIF4A1 eukaryotic translation initiation factor 4A1 0.0321726
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0321485
EIF4B eukaryotic translation initiation factor 4B 0.0319893
ZC3H11A zinc finger CCCH-type containing 11A 0.0319043
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0312664
POF1B premature ovarian failure, 1B 0.03068
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.0304654
JAK1 Janus kinase 1 0.0299685
RPL4 ribosomal protein L4 0.0297452
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0296935
GLS2 glutaminase 2 (liver, mitochondrial) 0.0294991
PHF3 PHD finger protein 3 0.0293703
CD2AP CD2-associated protein 0.029287
SRP72 signal recognition particle 72kDa 0.0291263
RPL12 ribosomal protein L12 0.0290188
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0284576
OSBPL8 oxysterol binding protein-like 8 0.028338
ENAH enabled homolog (Drosophila) 0.0282753
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0282038
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.028052
URI1 URI1, prefoldin-like chaperone 0.027775
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0276915
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0276717
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0265295
FUS FUS RNA binding protein 0.0264968
SSR1 signal sequence receptor, alpha 0.0264184
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0264079
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.026196
IPO7 importin 7 0.0261423
ATP5F1A ATP synthase F1 subunit alpha 0.0260809
ANKRD33B ankyrin repeat domain 33B 0.0259386
NSD3 nuclear receptor binding SET domain protein 3 0.0259225

decreased expression

Symbol Name Standardized Value
TENM3 teneurin transmembrane protein 3 -0.102452
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0916439
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.084317
CADM2 cell adhesion molecule 2 -0.0837825
FNDC3B fibronectin type III domain containing 3B -0.0822019
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0798987
PRTG protogenin -0.0779033
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0712179
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0668262
ADGRL2 adhesion G protein-coupled receptor L2 -0.0622454
PHIP pleckstrin homology domain interacting protein -0.0605498
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0598752
RPS6 ribosomal protein S6 -0.0582125
PFN1 profilin 1 -0.0572481
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0571374
NEBL nebulette -0.0488892
PARD3B par-3 family cell polarity regulator beta -0.0474921
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0433329
GREB1L growth regulation by estrogen in breast cancer-like -0.0428021
PDGFC platelet derived growth factor C -0.0425636
OSBPL10 oxysterol binding protein-like 10 -0.0421505
JMJD1C jumonji domain containing 1C -0.0411002
NFIA nuclear factor I/A -0.0395228
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0390508
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0379225
RBM20 RNA binding motif protein 20 -0.037627
UBE2K ubiquitin-conjugating enzyme E2K -0.0369556
CENPE centromere protein E, 312kDa -0.0365733
CCN2 cellular communication network factor 2 -0.0360336
CKAP2 cytoskeleton associated protein 2 -0.0356872
NRG1 neuregulin 1 -0.035027
CENPF centromere protein F, 350/400kDa -0.0350224
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0348811
ZNF217 zinc finger protein 217 -0.033646
FOXP2 forkhead box P2 -0.0330497
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0330107
ARHGAP15 Rho GTPase activating protein 15 -0.0323564
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0314143
ZFPM2 zinc finger protein, FOG family member 2 -0.031222
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0311923
SOX2 SRY (sex determining region Y)-box 2 -0.031129
PCDH7 protocadherin 7 -0.0306232
HSPB1 heat shock 27kDa protein 1 -0.0304087
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0301131
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0298981
RAB7A RAB7A, member RAS oncogene family -0.0296082
THOC2 THO complex 2 -0.0294496
RPL35A ribosomal protein L35a -0.0292815
TOP2A topoisomerase (DNA) II alpha 170kDa -0.029274
RERE arginine-glutamic acid dipeptide (RE) repeats -0.029172
TOX thymocyte selection-associated high mobility group box -0.0284809
TSC22D2 TSC22 domain family, member 2 -0.0279241
SYT1 synaptotagmin I -0.0274108
ATP5F1B ATP synthase F1 subunit beta -0.0273543
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0271746
RAD51B RAD51 paralog B -0.0270919
NCAM2 neural cell adhesion molecule 2 -0.0270278
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0267655
SLMAP sarcolemma associated protein -0.0266151
MIS18BP1 MIS18 binding protein 1 -0.0262387
NCOR2 nuclear receptor corepressor 2 -0.0260404
AK1 adenylate kinase 1 -0.0260017
CHD1 chromodomain helicase DNA binding protein 1 -0.0258749
TLK2 tousled-like kinase 2 -0.0258154
RPS19 ribosomal protein S19 -0.0257173
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0256629
KPNB1 karyopherin (importin) beta 1 -0.0256551
KLHL5 kelch-like family member 5 -0.0256189
H1-0 H1.0 linker histone -0.0255898
SRPK2 SRSF protein kinase 2 -0.0253651
ZEB2 zinc finger E-box binding homeobox 2 -0.0251888
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.024976
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0248889
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0247739
RPL32 ribosomal protein L32 -0.0246329
AFF1 AF4/FMR2 family, member 1 -0.0246219
ANK2 ankyrin 2, neuronal -0.0245406
FIGN fidgetin -0.0243269
TCERG1 transcription elongation regulator 1 -0.0241166
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0238448
MARCHF7 membrane associated ring-CH-type finger 7 -0.0238066
KDM5B lysine (K)-specific demethylase 5B -0.0237821
ZMYM2 zinc finger, MYM-type 2 -0.0237682
CCDC88A coiled-coil domain containing 88A -0.0236858
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0236586
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0235407
CLIP2 CAP-GLY domain containing linker protein 2 -0.0235237
NIPBL Nipped-B homolog (Drosophila) -0.0234903
HMGA2 high mobility group AT-hook 2 -0.0234882
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0234662
HM13 histocompatibility (minor) 13 -0.0233476
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0232953
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0232541
FAM177A1 family with sequence similarity 177, member A1 -0.0232414
MRPS30 mitochondrial ribosomal protein S30 -0.0232402
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0231901
TUT4 terminal uridylyl transferase 4 -0.02311
GRM1 glutamate receptor, metabotropic 1 -0.0230892
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0230599
TMEM135 transmembrane protein 135 -0.0229976