| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.18515 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.168124 |
| HDAC9 | histone deacetylase 9 | 0.159188 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.133467 |
| AHNAK | AHNAK nucleoprotein | 0.130431 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.128426 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.113868 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.10863 |
| B2M | beta-2-microglobulin | 0.105649 |
| RPS27A | ribosomal protein S27a | 0.0928871 |
| ENO1 | enolase 1, (alpha) | 0.0923938 |
| RPS8 | ribosomal protein S8 | 0.0914868 |
| ACTG1 | actin gamma 1 | 0.083754 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0832448 |
| UBC | ubiquitin C | 0.0823325 |
| JUN | jun proto-oncogene | 0.0795535 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0792366 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0766225 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0761076 |
| PCBP2 | poly(rC) binding protein 2 | 0.071049 |
| RPS3 | ribosomal protein S3 | 0.0684425 |
| LDHA | lactate dehydrogenase A | 0.0676681 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0671827 |
| ANXA1 | annexin A1 | 0.065783 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0640041 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0639405 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0596301 |
| PDGFC | platelet derived growth factor C | 0.0594255 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0589699 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0581429 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0556924 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0548097 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0526091 |
| RPL3 | ribosomal protein L3 | 0.0523857 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0518058 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0497676 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0493831 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0474529 |
| RPL23 | ribosomal protein L23 | 0.045938 |
| RPL4 | ribosomal protein L4 | 0.0455777 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0441347 |
| RHOA | ras homolog family member A | 0.0436495 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0420929 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0417227 |
| RPL31 | ribosomal protein L31 | 0.0414349 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0413134 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.04095 |
| RPS12 | ribosomal protein S12 | 0.0397354 |
| CALR | calreticulin | 0.0392235 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.0388185 |
| CDV3 | CDV3 homolog (mouse) | 0.0380447 |
| RPS19 | ribosomal protein S19 | 0.038026 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0379508 |
| RACK1 | receptor for activated C kinase 1 | 0.0378698 |
| APP | amyloid beta (A4) precursor protein | 0.0370519 |
| EFNA5 | ephrin-A5 | 0.0370095 |
| POTEF | POTE ankyrin domain family, member F | 0.0369623 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0365209 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.035472 |
| MYOF | myoferlin | 0.0322863 |
| RPL12 | ribosomal protein L12 | 0.0319174 |
| RPLP1 | ribosomal protein, large, P1 | 0.0315903 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0313594 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0308189 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 0.0308061 |
| SET | SET nuclear proto-oncogene | 0.0307993 |
| ANK2 | ankyrin 2, neuronal | 0.0306453 |
| OGA | O-GlcNAcase | 0.0306163 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0304411 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.030277 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.029946 |
| RPL7A | ribosomal protein L7a | 0.0298966 |
| RPL13A | ribosomal protein L13a | 0.0298911 |
| AMOTL2 | angiomotin like 2 | 0.0298338 |
| HLA-E | major histocompatibility complex, class I, E | 0.0290776 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0289449 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0289188 |
| RPLP0 | ribosomal protein, large, P0 | 0.0281588 |
| NFIA | nuclear factor I/A | 0.0280973 |
| RPL37A | ribosomal protein L37a | 0.0280912 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.028054 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0279923 |
| YBX1 | Y box binding protein 1 | 0.0270592 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0270527 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.02689 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0266804 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0265732 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0263286 |
| MSI2 | musashi RNA-binding protein 2 | 0.0263022 |
| RPS4X | ribosomal protein S4, X-linked | 0.0262073 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0261996 |
| ZNF608 | zinc finger protein 608 | 0.0261211 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0260296 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.025878 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0256496 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0255314 |
| PLCE1 | phospholipase C, epsilon 1 | 0.0254578 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0248927 |
| RPLP2 | ribosomal protein, large, P2 | 0.0246791 |
| MLIP | muscular LMNA-interacting protein | 0.0241668 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.202463 |
| PKM | pyruvate kinase, muscle | -0.171364 |
| VCL | vinculin | -0.146019 |
| FLNB | filamin B, beta | -0.137478 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.129965 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.126781 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0930666 |
| BMP10 | bone morphogenetic protein 10 | -0.0911157 |
| CCND1 | cyclin D1 | -0.0884899 |
| PYGB | phosphorylase, glycogen; brain | -0.0754549 |
| GLI3 | GLI family zinc finger 3 | -0.0743609 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0722346 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0716426 |
| NBEA | neurobeachin | -0.0620032 |
| LOXL3 | lysyl oxidase-like 3 | -0.0605315 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.0601959 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0601859 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0571489 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0564475 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0551915 |
| GLI2 | GLI family zinc finger 2 | -0.0530006 |
| ECT2 | epithelial cell transforming 2 | -0.0527807 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.05175 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0516638 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0491614 |
| HJURP | Holliday junction recognition protein | -0.0488763 |
| TJP1 | tight junction protein 1 | -0.048689 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0474459 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0460501 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0445539 |
| PIWIL1 | piwi-like RNA-mediated gene silencing 1 | -0.0440381 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0416923 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0415359 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0412272 |
| DUSP6 | dual specificity phosphatase 6 | -0.0405541 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0394658 |
| FOXP1 | forkhead box P1 | -0.0384168 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.038295 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0378643 |
| NF1 | neurofibromin 1 | -0.0373261 |
| RTN4 | reticulon 4 | -0.0363303 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0360059 |
| PFN1 | profilin 1 | -0.0351828 |
| DUSP4 | dual specificity phosphatase 4 | -0.0350936 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0348443 |
| BMP2K | BMP2 inducible kinase | -0.0344657 |
| ETV5 | ets variant 5 | -0.0337937 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0335997 |
| USP34 | ubiquitin specific peptidase 34 | -0.0322364 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0322001 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0315408 |
| ITGA10 | integrin, alpha 10 | -0.0304151 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0297707 |
| MYO5C | myosin VC | -0.0295384 |
| NAV2 | neuron navigator 2 | -0.0288336 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0287763 |
| GSE1 | Gse1 coiled-coil protein | -0.0282542 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0281852 |
| TXNRD1 | thioredoxin reductase 1 | -0.0277974 |
| TMEM65 | transmembrane protein 65 | -0.0277629 |
| SEPTIN9 | septin 9 | -0.0270319 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0265175 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0261106 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0260604 |
| NBAS | neuroblastoma amplified sequence | -0.0258367 |
| TOB1 | transducer of ERBB2, 1 | -0.0257524 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0251143 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.0249778 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | -0.024756 |
| NUP58 | nucleoporin 58 | -0.0246385 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0244132 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0240866 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0239784 |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) | -0.0235687 |
| SBF2 | SET binding factor 2 | -0.022642 |
| ANKRD36B | ankyrin repeat domain 36B | -0.0225223 |
| ATP9B | ATPase, class II, type 9B | -0.0225056 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0224864 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0218606 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0217182 |
| TMEM41B | transmembrane protein 41B | -0.0214393 |
| JMJD1C | jumonji domain containing 1C | -0.0213958 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0212419 |
| LIMD1 | LIM domains containing 1 | -0.021051 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0209221 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.020593 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0204486 |
| EXOC6B | exocyst complex component 6B | -0.0203702 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0203075 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0199292 |
| SRPK2 | SRSF protein kinase 2 | -0.0199266 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0198692 |
| S100A11 | S100 calcium binding protein A11 | -0.0198562 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0193501 |
| PLXNA2 | plexin A2 | -0.0193226 |
| ITGA6 | integrin, alpha 6 | -0.0186413 |
| DENND1A | DENN/MADD domain containing 1A | -0.0185664 |
| RRM2 | ribonucleotide reductase M2 | -0.0182592 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0181487 |
| TMEM39A | transmembrane protein 39A | -0.0181105 |
