| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.18362 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.173886 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.149145 |
| LDHA | lactate dehydrogenase A | 0.116988 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.106621 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.103163 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.102872 |
| DST | dystonin | 0.102751 |
| PLIN2 | perilipin 2 | 0.101019 |
| ENO1 | enolase 1, (alpha) | 0.097773 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.09771 |
| MYOF | myoferlin | 0.0912453 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0852706 |
| PCBP2 | poly(rC) binding protein 2 | 0.0827625 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0762073 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0719949 |
| AHNAK | AHNAK nucleoprotein | 0.070228 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.070095 |
| CADM1 | cell adhesion molecule 1 | 0.0682026 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0657184 |
| ADM | adrenomedullin | 0.0653745 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0636111 |
| CALR | calreticulin | 0.0634331 |
| ARRDC3 | arrestin domain containing 3 | 0.0632659 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0625709 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0620133 |
| B2M | beta-2-microglobulin | 0.0616436 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0584192 |
| VEGFA | vascular endothelial growth factor A | 0.0582957 |
| CANX | calnexin | 0.0580559 |
| GOLGB1 | golgin B1 | 0.0577084 |
| TXNIP | thioredoxin interacting protein | 0.0542434 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0527764 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0507903 |
| ZNF292 | zinc finger protein 292 | 0.0502831 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0487285 |
| RND3 | Rho family GTPase 3 | 0.048611 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0485884 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0470752 |
| UBC | ubiquitin C | 0.0467865 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0457256 |
| APP | amyloid beta (A4) precursor protein | 0.0456467 |
| HDAC9 | histone deacetylase 9 | 0.0454146 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0451078 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0439692 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0438224 |
| MX1 | MX dynamin-like GTPase 1 | 0.0429837 |
| VCAN | versican | 0.0418728 |
| FNIP1 | folliculin interacting protein 1 | 0.0409941 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0395948 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0394773 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0390541 |
| ANXA1 | annexin A1 | 0.03885 |
| RPL3 | ribosomal protein L3 | 0.0384407 |
| PRELID2 | PRELI domain containing 2 | 0.0379139 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0378233 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0376148 |
| MMP12 | matrix metallopeptidase 12 | 0.0375138 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0373707 |
| FN1 | fibronectin 1 | 0.0373004 |
| ARFGEF3 | ARFGEF family member 3 | 0.0372784 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0367327 |
| TMSB4X | thymosin beta 4, X-linked | 0.0363486 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0354309 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0342969 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.034041 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0337886 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0336754 |
| PHF3 | PHD finger protein 3 | 0.0336168 |
| EGFR | epidermal growth factor receptor | 0.0335399 |
| CDK19 | cyclin-dependent kinase 19 | 0.0334414 |
| LRRC7 | leucine rich repeat containing 7 | 0.0325069 |
| GOLGA4 | golgin A4 | 0.0318372 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0318166 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0315537 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0314682 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0314638 |
| NDRG1 | N-myc downstream regulated 1 | 0.0312384 |
| RNF213 | ring finger protein 213 | 0.031024 |
| FLNB | filamin B, beta | 0.0310223 |
| OPTN | optineurin | 0.0309973 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0305664 |
| SNX3 | sorting nexin 3 | 0.0301601 |
| HLA-E | major histocompatibility complex, class I, E | 0.029859 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0297823 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0297622 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.0296552 |
| TNS3 | tensin 3 | 0.0295076 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0293178 |
| SFTPA2 | surfactant protein A2 | 0.0289462 |
| VIM | vimentin | 0.0287144 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0285443 |
| PTEN | phosphatase and tensin homolog | 0.0284342 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0282394 |
| TPM3 | tropomyosin 3 | 0.0282317 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0281922 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.028034 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0278312 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0277392 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0275691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.151878 |
| IER3 | immediate early response 3 | -0.149889 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.10701 |
| GLIS3 | GLIS family zinc finger 3 | -0.0932186 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0869612 |
| RPS24 | ribosomal protein S24 | -0.0815712 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0813189 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0601352 |
| RPS6 | ribosomal protein S6 | -0.0587425 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0551804 |
| FTL | ferritin, light polypeptide | -0.0530997 |
| HMGA2 | high mobility group AT-hook 2 | -0.0515639 |
| CD44 | CD44 molecule (Indian blood group) | -0.0503592 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0487986 |
| RPLP1 | ribosomal protein, large, P1 | -0.0483994 |
| BICC1 | BicC family RNA binding protein 1 | -0.0465106 |
| RPL35A | ribosomal protein L35a | -0.04552 |
| VCL | vinculin | -0.045479 |
| MT2A | metallothionein 2A | -0.04381 |
| RPL38 | ribosomal protein L38 | -0.0429495 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0419981 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0415861 |
| TPM4 | tropomyosin 4 | -0.0412594 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.039475 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0392017 |
| RPLP2 | ribosomal protein, large, P2 | -0.0388628 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0385957 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0383234 |
| PTMA | prothymosin, alpha | -0.0379604 |
| RPS21 | ribosomal protein S21 | -0.0376721 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0366321 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0360798 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0358528 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0356913 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0349471 |
| RTN4 | reticulon 4 | -0.0330875 |
| RPL28 | ribosomal protein L28 | -0.032994 |
| RPS8 | ribosomal protein S8 | -0.032807 |
| RPL36A | ribosomal protein L36a | -0.0327869 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0324873 |
| SNX9 | sorting nexin 9 | -0.0306887 |
| TOP1 | topoisomerase (DNA) I | -0.0305416 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0303834 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0302245 |
| RPL37A | ribosomal protein L37a | -0.0301703 |
| CTSD | cathepsin D | -0.0296343 |
| HMGA1 | high mobility group AT-hook 1 | -0.0296327 |
| RPS19 | ribosomal protein S19 | -0.0293875 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0291728 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0277654 |
| RPL26 | ribosomal protein L26 | -0.0274278 |
| RPS15 | ribosomal protein S15 | -0.027093 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0268945 |
| CAVIN1 | caveolae associated protein 1 | -0.0267495 |
| HLA-B | major histocompatibility complex, class I, B | -0.0267337 |
| ATP13A3 | ATPase type 13A3 | -0.0266466 |
| SMAD3 | SMAD family member 3 | -0.0263689 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.026295 |
| COL1A1 | collagen, type I, alpha 1 | -0.0260656 |
| RPL34 | ribosomal protein L34 | -0.0260644 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0254951 |
| RPL8 | ribosomal protein L8 | -0.0253868 |
| RPL19 | ribosomal protein L19 | -0.0253439 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0252629 |
| RPS25 | ribosomal protein S25 | -0.0250039 |
| ERBIN | erbb2 interacting protein | -0.0249009 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0248568 |
| USP3 | ubiquitin specific peptidase 3 | -0.024812 |
| RPL11 | ribosomal protein L11 | -0.024525 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | -0.0245024 |
| KYNU | kynureninase | -0.0244503 |
| RPLP0 | ribosomal protein, large, P0 | -0.0244229 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0242781 |
| RPS29 | ribosomal protein S29 | -0.0241946 |
| RBM39 | RNA binding motif protein 39 | -0.0241338 |
| RPL39 | ribosomal protein L39 | -0.024031 |
| RPS23 | ribosomal protein S23 | -0.0240178 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0238736 |
| HMGB1 | high mobility group box 1 | -0.0236684 |
| RHEB | Ras homolog enriched in brain | -0.0236678 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0236592 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.023608 |
| CLMP | CXADR-like membrane protein | -0.0232875 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0232317 |
| QKI | QKI, KH domain containing, RNA binding | -0.0230104 |
| ACTG1 | actin gamma 1 | -0.0229162 |
| RPS14 | ribosomal protein S14 | -0.0228156 |
| SRGN | serglycin | -0.0223691 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0221992 |
| WTAP | Wilms tumor 1 associated protein | -0.0220035 |
| RPL36 | ribosomal protein L36 | -0.0218787 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0218135 |
| RPS16 | ribosomal protein S16 | -0.0217885 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0212934 |
| RRBP1 | ribosome binding protein 1 | -0.0212738 |
| RPS13 | ribosomal protein S13 | -0.0211465 |
| RPL32 | ribosomal protein L32 | -0.0210631 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0209773 |
| NABP1 | nucleic acid binding protein 1 | -0.0208765 |
| FMNL2 | formin-like 2 | -0.0207553 |
