| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.427512 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.150404 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.135948 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.12129 |
| CALR | calreticulin | 0.100639 |
| AHNAK | AHNAK nucleoprotein | 0.100312 |
| ENO1 | enolase 1, (alpha) | 0.090682 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0881701 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.079454 |
| COL5A1 | collagen, type V, alpha 1 | 0.0706399 |
| MYOF | myoferlin | 0.0635797 |
| ANXA2 | annexin A2 | 0.0604958 |
| CALU | calumenin | 0.0599789 |
| POTEF | POTE ankyrin domain family, member F | 0.0599349 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0567548 |
| SDC4 | syndecan 4 | 0.0560683 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.054575 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0536474 |
| LDHA | lactate dehydrogenase A | 0.0527311 |
| FLNA | filamin A, alpha | 0.0525542 |
| CANX | calnexin | 0.0518055 |
| HDLBP | high density lipoprotein binding protein | 0.0482166 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0469707 |
| TXNIP | thioredoxin interacting protein | 0.0463569 |
| ANXA1 | annexin A1 | 0.0453051 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0440565 |
| FNIP1 | folliculin interacting protein 1 | 0.0434291 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0432277 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0430594 |
| B2M | beta-2-microglobulin | 0.0415709 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0411406 |
| CD44 | CD44 molecule (Indian blood group) | 0.040754 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0403041 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0390909 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0379575 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0373759 |
| C1D | C1D nuclear receptor corepressor | 0.0364644 |
| LAMB1 | laminin, beta 1 | 0.0364542 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0363108 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0362088 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0362084 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.0358197 |
| ARRDC3 | arrestin domain containing 3 | 0.0348325 |
| COL1A2 | collagen, type I, alpha 2 | 0.0346972 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0343733 |
| MTREX | Mtr4 exosome RNA helicase | 0.0339166 |
| FAM13A | family with sequence similarity 13, member A | 0.0338247 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0335728 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0332405 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0330944 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0330437 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.032998 |
| KIF16B | kinesin family member 16B | 0.0328724 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0328051 |
| SRP54 | signal recognition particle 54kDa | 0.0327629 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0327 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0326334 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0321405 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0316361 |
| SBF2 | SET binding factor 2 | 0.0315568 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0313458 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0312088 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0310063 |
| LOXL2 | lysyl oxidase-like 2 | 0.0307587 |
| ANXA5 | annexin A5 | 0.030641 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.030375 |
| AHR | aryl hydrocarbon receptor | 0.0300447 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0294448 |
| PLEC | plectin | 0.0291728 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0291602 |
| TPM3 | tropomyosin 3 | 0.0291053 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0287945 |
| CTSB | cathepsin B | 0.0287861 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0285148 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0284568 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0284116 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0281703 |
| PRELID2 | PRELI domain containing 2 | 0.0280095 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0278931 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0277696 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.0276905 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0276211 |
| USPL1 | ubiquitin specific peptidase like 1 | 0.0275772 |
| ZNF395 | zinc finger protein 395 | 0.0274067 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0274064 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0272403 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0272361 |
| MYO9A | myosin IXA | 0.027179 |
| NRXN3 | neurexin 3 | 0.0268694 |
| RND3 | Rho family GTPase 3 | 0.0266355 |
| SEPTIN2 | septin 2 | 0.0265751 |
| SERINC1 | serine incorporator 1 | 0.0265069 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0262416 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0261727 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0259767 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0258843 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0257879 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0256437 |
| PTN | pleiotrophin | 0.0253402 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.024785 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.152371 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.144486 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.127413 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.123458 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.081942 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0745401 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0725102 |
| RAI14 | retinoic acid induced 14 | -0.057477 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0569689 |
| CDH13 | cadherin 13 | -0.0561215 |
| GLIS3 | GLIS family zinc finger 3 | -0.0557075 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0549889 |
| HMGA2 | high mobility group AT-hook 2 | -0.050963 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0497941 |
| ZNF292 | zinc finger protein 292 | -0.046855 |
| TMSB10 | thymosin beta 10 | -0.045833 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0443174 |
| HLA-B | major histocompatibility complex, class I, B | -0.0398224 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0392477 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0389576 |
| SMAD3 | SMAD family member 3 | -0.0378437 |
| ASPH | aspartate beta-hydroxylase | -0.0376587 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0372571 |
| RPS6 | ribosomal protein S6 | -0.0351411 |
| RASAL2 | RAS protein activator like 2 | -0.0343291 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0339859 |
| FUS | FUS RNA binding protein | -0.0339505 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0321247 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0319264 |
| RBM39 | RNA binding motif protein 39 | -0.0317975 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.031614 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0313179 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0312606 |
| RPL31 | ribosomal protein L31 | -0.0307757 |
| NRP1 | neuropilin 1 | -0.0302568 |
| MRTFA | myocardin related transcription factor A | -0.0302469 |
| FMNL2 | formin-like 2 | -0.0296889 |
| RPL35A | ribosomal protein L35a | -0.0294363 |
| TAGLN2 | transgelin 2 | -0.0289787 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0289674 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0283827 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0283572 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0278879 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0272978 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0267877 |
| QKI | QKI, KH domain containing, RNA binding | -0.0260699 |
| MT1X | metallothionein 1X | -0.0258187 |
| RUNX1 | runt-related transcription factor 1 | -0.0258013 |
| TPM4 | tropomyosin 4 | -0.0253046 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0252269 |
| GPC6 | glypican 6 | -0.0251476 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0250911 |
| STC1 | stanniocalcin 1 | -0.024972 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0248539 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0248296 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0247304 |
| PHKB | phosphorylase kinase, beta | -0.0246975 |
| RPS19 | ribosomal protein S19 | -0.0246114 |
| MED13L | mediator complex subunit 13-like | -0.024082 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0240129 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0235329 |
| PRKCA | protein kinase C, alpha | -0.0235234 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0234357 |
| RPL34 | ribosomal protein L34 | -0.0234127 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0231774 |
| MYLK | myosin light chain kinase | -0.0231693 |
| EFNA5 | ephrin-A5 | -0.0231568 |
| DTNA | dystrobrevin, alpha | -0.0230318 |
| CUL3 | cullin 3 | -0.0226986 |
| RPL36A | ribosomal protein L36a | -0.0224117 |
| INHBA | inhibin, beta A | -0.0223392 |
| SEPTIN7 | septin 7 | -0.0222251 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0221969 |
| FOSL1 | FOS-like antigen 1 | -0.0220206 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0219675 |
| PFN1 | profilin 1 | -0.0219646 |
| RPL37 | ribosomal protein L37 | -0.0218754 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0218089 |
| RPS29 | ribosomal protein S29 | -0.0215807 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0215691 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0214481 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0212014 |
| RPL11 | ribosomal protein L11 | -0.0211564 |
| SRPK2 | SRSF protein kinase 2 | -0.0209949 |
| TRIM9 | tripartite motif containing 9 | -0.0208992 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0208685 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0207259 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.020717 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0200385 |
| RPL8 | ribosomal protein L8 | -0.0200325 |
| OSMR | oncostatin M receptor | -0.0200319 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0200311 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0199958 |
| RPL27A | ribosomal protein L27a | -0.0199534 |
| BBX | bobby sox homolog (Drosophila) | -0.0198878 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0198564 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0198154 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0197608 |
| FBXO11 | F-box protein 11 | -0.0197189 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | -0.0197156 |
