| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.175168 |
| LDHA | lactate dehydrogenase A | 0.105785 |
| ANXA2 | annexin A2 | 0.0911863 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0781655 |
| PTMA | prothymosin, alpha | 0.076902 |
| ENO1 | enolase 1, (alpha) | 0.0740511 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0709448 |
| ANXA1 | annexin A1 | 0.0693623 |
| CANX | calnexin | 0.0613996 |
| POTEF | POTE ankyrin domain family, member F | 0.060759 |
| TXNRD1 | thioredoxin reductase 1 | 0.0607104 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.058252 |
| MAP1B | microtubule-associated protein 1B | 0.0563342 |
| AHNAK | AHNAK nucleoprotein | 0.0555388 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0555322 |
| ACTG1 | actin gamma 1 | 0.0546029 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0524235 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0511497 |
| DST | dystonin | 0.0506366 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0504902 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0496453 |
| CALR | calreticulin | 0.0491289 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0490837 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0490169 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0489684 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0482369 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0481828 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0473213 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0454028 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0441693 |
| RPL4 | ribosomal protein L4 | 0.0434835 |
| MYOF | myoferlin | 0.0430498 |
| RNF213 | ring finger protein 213 | 0.0412196 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0406467 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0402556 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0401876 |
| UBC | ubiquitin C | 0.0392139 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0389287 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0381581 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0378999 |
| TXNIP | thioredoxin interacting protein | 0.0378666 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0362211 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0360268 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0356968 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0346662 |
| HDLBP | high density lipoprotein binding protein | 0.0341772 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0334059 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0329433 |
| PHF3 | PHD finger protein 3 | 0.0326021 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0319499 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0315682 |
| PKM | pyruvate kinase, muscle | 0.0314398 |
| INTS6 | integrator complex subunit 6 | 0.0313194 |
| FNIP1 | folliculin interacting protein 1 | 0.0305198 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0303656 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.029794 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0292421 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0291892 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0284792 |
| SQSTM1 | sequestosome 1 | 0.0284715 |
| PTEN | phosphatase and tensin homolog | 0.0284598 |
| CEP250 | centrosomal protein 250kDa | 0.0284195 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0279736 |
| INSIG1 | insulin induced gene 1 | 0.0276362 |
| PCBP2 | poly(rC) binding protein 2 | 0.027562 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0268568 |
| SET | SET nuclear proto-oncogene | 0.0266897 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0266823 |
| WWOX | WW domain containing oxidoreductase | 0.0263667 |
| CREBBP | CREB binding protein | 0.0263459 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0263243 |
| SIK3 | SIK family kinase 3 | 0.0260928 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0260724 |
| JMJD1C | jumonji domain containing 1C | 0.0259795 |
| AFDN | afadin, adherens junction formation factor | 0.0257233 |
| NEK1 | NIMA-related kinase 1 | 0.0256564 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0256299 |
| ERGIC3 | ERGIC and golgi 3 | 0.0255238 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0251144 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0250756 |
| AHR | aryl hydrocarbon receptor | 0.0246726 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.02464 |
| DMXL1 | Dmx-like 1 | 0.0243712 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0243652 |
| LATS2 | large tumor suppressor kinase 2 | 0.0242896 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0239673 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0239619 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 0.0237823 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0234922 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0232833 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0231393 |
| UTRN | utrophin | 0.0230801 |
| YBX1 | Y box binding protein 1 | 0.0230253 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0229234 |
| ARCN1 | archain 1 | 0.0224193 |
| CUX1 | cut-like homeobox 1 | 0.0224133 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0222904 |
| CREBRF | CREB3 regulatory factor | 0.0221153 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0220576 |
| SFTPA2 | surfactant protein A2 | 0.0219566 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.11171 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.100714 |
| MT2A | metallothionein 2A | -0.0916576 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0863327 |
| FMNL2 | formin-like 2 | -0.0831543 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0761456 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0726884 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0684868 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0677213 |
| NF1 | neurofibromin 1 | -0.0644547 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0632627 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0625646 |
| SNX14 | sorting nexin 14 | -0.0623617 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0610495 |
| CD44 | CD44 molecule (Indian blood group) | -0.0606749 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0603173 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0597912 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0589817 |
| CDCP1 | CUB domain containing protein 1 | -0.057906 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0562876 |
| PDE8A | phosphodiesterase 8A | -0.0561091 |
| FLNB | filamin B, beta | -0.0557269 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.055539 |
| GOLGA4 | golgin A4 | -0.0554703 |
| TMSB10 | thymosin beta 10 | -0.0554328 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0552818 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0545595 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0542122 |
| DNER | delta/notch-like EGF repeat containing | -0.0531936 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0529015 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0525693 |
| RBM39 | RNA binding motif protein 39 | -0.052402 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0523519 |
| YBX3 | Y box binding protein 3 | -0.0518721 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0517761 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0515883 |
| OSMR | oncostatin M receptor | -0.0513664 |
| SPAG9 | sperm associated antigen 9 | -0.0510055 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0494348 |
| HMGA2 | high mobility group AT-hook 2 | -0.0493241 |
| ATG7 | autophagy related 7 | -0.0491995 |
| ETV1 | ets variant 1 | -0.0490636 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0488167 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0484496 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.048418 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0469947 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0463255 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0461406 |
| RIGI | RNA sensor RIG-I | -0.045776 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0454738 |
| TPX2 | TPX2, microtubule-associated | -0.0445795 |
| RIN2 | Ras and Rab interactor 2 | -0.0439519 |
| VIM | vimentin | -0.0437297 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0437222 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0433195 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0424974 |
| ANGPTL4 | angiopoietin-like 4 | -0.0422753 |
| ASPH | aspartate beta-hydroxylase | -0.0421194 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0409864 |
| CEP170 | centrosomal protein 170kDa | -0.0405978 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0404981 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0403756 |
| NAV2 | neuron navigator 2 | -0.0401455 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0400594 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0393875 |
| ETV5 | ets variant 5 | -0.0387418 |
| DTNA | dystrobrevin, alpha | -0.038483 |
| ACER3 | alkaline ceramidase 3 | -0.0383551 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.038263 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0380927 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0375664 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0368566 |
| HJURP | Holliday junction recognition protein | -0.0368516 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.036838 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0363082 |
| MED17 | mediator complex subunit 17 | -0.0362701 |
| SMYD3 | SET and MYND domain containing 3 | -0.0361867 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0361628 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0357149 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0352427 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0352231 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0349352 |
| SETX | senataxin | -0.0348488 |
| STXBP1 | syntaxin binding protein 1 | -0.0343306 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0339882 |
| NKTR | natural killer cell triggering receptor | -0.0338451 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0337037 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0332323 |
| GNAS | GNAS complex locus | -0.032706 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0326983 |
| EFL1 | elongation factor like GTPase 1 | -0.0326713 |
| IGF2 | insulin-like growth factor 2 | -0.0325205 |
| SETD5 | SET domain containing 5 | -0.0325096 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0323667 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0323305 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0322385 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0321599 |
| PHF20 | PHD finger protein 20 | -0.0320675 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0320185 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0318936 |
