| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Binimetinib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Binimetinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | 0.214082 |
| FN1 | fibronectin 1 | 0.0877379 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0869518 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0866054 |
| THBS1 | thrombospondin 1 | 0.0825414 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0790447 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0777578 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0776642 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0771973 |
| AHR | aryl hydrocarbon receptor | 0.0771793 |
| TXNIP | thioredoxin interacting protein | 0.0770491 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0733687 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0732975 |
| TPR | translocated promoter region, nuclear basket protein | 0.0723808 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0715664 |
| VCL | vinculin | 0.0714751 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0710179 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0694081 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0693955 |
| SFTPA2 | surfactant protein A2 | 0.067186 |
| ENO1 | enolase 1, (alpha) | 0.0621384 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0609965 |
| ENAH | enabled homolog (Drosophila) | 0.0603777 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0598991 |
| AOPEP | aminopeptidase O (putative) | 0.0596594 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0578969 |
| DST | dystonin | 0.0578218 |
| TNS3 | tensin 3 | 0.0563101 |
| B2M | beta-2-microglobulin | 0.0540767 |
| CD109 | CD109 molecule | 0.0535547 |
| KSR1 | kinase suppressor of ras 1 | 0.0521356 |
| PALLD | palladin, cytoskeletal associated protein | 0.0519399 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0506107 |
| CALR | calreticulin | 0.0502203 |
| POTEF | POTE ankyrin domain family, member F | 0.0495472 |
| MYOF | myoferlin | 0.0490385 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0485956 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0476604 |
| PLIN2 | perilipin 2 | 0.0473133 |
| SIRT1 | sirtuin 1 | 0.046499 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0462953 |
| CFB | complement factor B | 0.0459181 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0451033 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0450222 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0449327 |
| RUNX2 | runt-related transcription factor 2 | 0.0446448 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.043979 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0437854 |
| TXNRD1 | thioredoxin reductase 1 | 0.0435879 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0434166 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0427676 |
| DSCAM | Down syndrome cell adhesion molecule | 0.042343 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0419684 |
| RASAL2 | RAS protein activator like 2 | 0.0418495 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0417885 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0411036 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0406214 |
| TCIM | transcriptional and immune response regulator | 0.0405104 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0404873 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0400408 |
| LMNA | lamin A/C | 0.0397362 |
| AEBP2 | AE binding protein 2 | 0.039338 |
| CANX | calnexin | 0.0390986 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0386817 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0376913 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0366335 |
| UBC | ubiquitin C | 0.0361506 |
| RNF213 | ring finger protein 213 | 0.0349103 |
| TGFB2 | transforming growth factor, beta 2 | 0.0348652 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0344842 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0339655 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0337737 |
| GPC6 | glypican 6 | 0.0336254 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0335529 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0329015 |
| USP34 | ubiquitin specific peptidase 34 | 0.0325765 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0325508 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0319411 |
| RBM47 | RNA binding motif protein 47 | 0.0318569 |
| AHNAK | AHNAK nucleoprotein | 0.0318185 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0316992 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0313501 |
| MCL1 | myeloid cell leukemia 1 | 0.0312827 |
| ADAR | adenosine deaminase, RNA-specific | 0.0307975 |
| CCNL1 | cyclin L1 | 0.0302895 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0299078 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0294708 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0294577 |
| PCBP2 | poly(rC) binding protein 2 | 0.0292778 |
| OSMR | oncostatin M receptor | 0.0290324 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0288945 |
| RAB10 | RAB10, member RAS oncogene family | 0.0286997 |
| NBEA | neurobeachin | 0.0283337 |
| HMGB3 | high mobility group box 3 | 0.0282963 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0278223 |
| STC2 | stanniocalcin 2 | 0.0278183 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.027495 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0272831 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0272307 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0268895 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.204988 |
| ITGA1 | integrin, alpha 1 | -0.187316 |
| HMGA2 | high mobility group AT-hook 2 | -0.178067 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.147146 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.144483 |
| NRG1 | neuregulin 1 | -0.123242 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0987374 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0901505 |
| ASPH | aspartate beta-hydroxylase | -0.0836187 |
| MT2A | metallothionein 2A | -0.0748578 |
| NDRG1 | N-myc downstream regulated 1 | -0.0707026 |
| SQSTM1 | sequestosome 1 | -0.0694256 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0672975 |
| PELO | pelota homolog (Drosophila) | -0.0643915 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.063038 |
| RPL35A | ribosomal protein L35a | -0.0579881 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0576623 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0518878 |
| EREG | epiregulin | -0.0498053 |
| HPCAL1 | hippocalcin-like 1 | -0.0498026 |
| PTK2 | protein tyrosine kinase 2 | -0.0490173 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0476693 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0472592 |
| TMSB10 | thymosin beta 10 | -0.046644 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0454938 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0453817 |
| CDCP1 | CUB domain containing protein 1 | -0.0452984 |
| RPS6 | ribosomal protein S6 | -0.0445237 |
| HMGA1 | high mobility group AT-hook 1 | -0.0439668 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.042685 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0424124 |
| TMEM156 | transmembrane protein 156 | -0.0410523 |
| TOP1 | topoisomerase (DNA) I | -0.0409889 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0400693 |
| SMAD3 | SMAD family member 3 | -0.039828 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0396971 |
| FNBP1 | formin binding protein 1 | -0.0393304 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0381749 |
| IER3 | immediate early response 3 | -0.0369072 |
| RPL38 | ribosomal protein L38 | -0.0361776 |
| RPS20 | ribosomal protein S20 | -0.0360299 |
| FTL | ferritin, light polypeptide | -0.035556 |
| DUSP6 | dual specificity phosphatase 6 | -0.0352171 |
| TGFA | transforming growth factor, alpha | -0.0331808 |
| RPS8 | ribosomal protein S8 | -0.0329756 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0326129 |
| ETV1 | ets variant 1 | -0.0322386 |
| RPL31 | ribosomal protein L31 | -0.0316697 |
| RPL9 | ribosomal protein L9 | -0.0316423 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0310432 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0310296 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0307976 |
| ITGB5 | integrin, beta 5 | -0.03018 |
| RRBP1 | ribosome binding protein 1 | -0.0298299 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0295084 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0291038 |
| CD44 | CD44 molecule (Indian blood group) | -0.0288718 |
| USP3 | ubiquitin specific peptidase 3 | -0.0286911 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0284859 |
| RTN4 | reticulon 4 | -0.0281263 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0281204 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0281174 |
| PDE8A | phosphodiesterase 8A | -0.0280785 |
| VIM | vimentin | -0.0280075 |
| NRP1 | neuropilin 1 | -0.0279193 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0275749 |
| RPL34 | ribosomal protein L34 | -0.0275226 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0273718 |
| RPL28 | ribosomal protein L28 | -0.0270452 |
| RPS12 | ribosomal protein S12 | -0.0270441 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0270307 |
| RPS24 | ribosomal protein S24 | -0.0268335 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0266901 |
| RPS16 | ribosomal protein S16 | -0.0263516 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0257413 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0256473 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0256379 |
| RPL12 | ribosomal protein L12 | -0.025519 |
| TJP1 | tight junction protein 1 | -0.0254269 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0248198 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0247913 |
| HMGB1 | high mobility group box 1 | -0.0242245 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0239556 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0238695 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0238212 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0236172 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0236093 |
| FUS | FUS RNA binding protein | -0.0235044 |
| RPS29 | ribosomal protein S29 | -0.0235029 |
| RPL23 | ribosomal protein L23 | -0.0232951 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0226956 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0226761 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0226712 |
| FOSL1 | FOS-like antigen 1 | -0.0226282 |
| RPL13A | ribosomal protein L13a | -0.0225749 |
| RPS25 | ribosomal protein S25 | -0.0225581 |
| RPS27 | ribosomal protein S27 | -0.0225189 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.02235 |
| SEPTIN7 | septin 7 | -0.0222983 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0222754 |
