| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/60769 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Binospirone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RETREG1 | reticulophagy regulator 1 | 2.31 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.38 |
| TRMT13 | tRNA methyltransferase 13 homolog (S. cerevisiae) | 1.05 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.92 |
| COMMD3 | COMM domain containing 3 | 0.81 |
| KLHL23 | kelch-like family member 23 | 0.78 |
| SIRT3 | sirtuin 3 | 0.74 |
| PISD | phosphatidylserine decarboxylase | 0.74 |
| NEK4 | NIMA-related kinase 4 | 0.72 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.69 |
| CCDC90B | coiled-coil domain containing 90B | 0.66 |
| TESK1 | testis-specific kinase 1 | 0.66 |
| CLIC3 | chloride intracellular channel 3 | 0.65 |
| MED10 | mediator complex subunit 10 | 0.64 |
| METTL26 | methyltransferase like 26 | 0.62 |
| ANKRD39 | ankyrin repeat domain 39 | 0.6 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.55 |
| PGLS | 6-phosphogluconolactonase | 0.55 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | 0.55 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.55 |
| C5ORF51 | chromosome 5 open reading frame 51 | 0.54 |
| ZNF3 | zinc finger protein 3 | 0.53 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.53 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.52 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.51 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.51 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.51 |
| GSE1 | Gse1 coiled-coil protein | 0.51 |
| VGLL4 | vestigial-like family member 4 | 0.5 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | 0.5 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | 0.5 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.49 |
| UNC5B | unc-5 homolog B (C. elegans) | 0.49 |
| N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative) | 0.49 |
| HPCAL4 | hippocalcin like 4 | 0.49 |
| TMSB10 | thymosin beta 10 | 0.49 |
| HAUS1 | HAUS augmin-like complex, subunit 1 | 0.48 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.48 |
| ZNF445 | zinc finger protein 445 | 0.48 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.48 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.47 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | 0.47 |
| RNF185 | ring finger protein 185 | 0.47 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.47 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | 0.46 |
| MIS12 | MIS12 kinetochore complex component | 0.46 |
| COPS4 | COP9 signalosome subunit 4 | 0.46 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.46 |
| CLPP | caseinolytic mitochondrial matrix peptidase proteolytic subunit | 0.45 |
| NAXE | NAD(P)HX epimerase | 0.44 |
| COPE | coatomer protein complex, subunit epsilon | 0.44 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.44 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.44 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.44 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.44 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 0.43 |
| CNTNAP1 | contactin associated protein 1 | 0.43 |
| CD320 | CD320 molecule | 0.43 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.43 |
| ACY1 | aminoacylase 1 | 0.43 |
| PSMG4 | proteasome (prosome, macropain) assembly chaperone 4 | 0.43 |
| NUTF2 | nuclear transport factor 2 | 0.43 |
| LYPLA2 | lysophospholipase II | 0.43 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.43 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.42 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.42 |
| ADI1 | acireductone dioxygenase 1 | 0.42 |
| OSBPL7 | oxysterol binding protein-like 7 | 0.42 |
| GON7 | GON7 subunit of KEOPS complex | 0.41 |
| COPS8 | COP9 signalosome subunit 8 | 0.41 |
| HECA | headcase homolog (Drosophila) | 0.41 |
| H3C1 | H3 clustered histone 1 | 0.41 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.41 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | 0.4 |
| DAP | death-associated protein | 0.4 |
| PFDN1 | prefoldin subunit 1 | 0.4 |
| PLCB4 | phospholipase C, beta 4 | 0.4 |
| HIST2H2AB | histone cluster 2, H2ab | 0.4 |
| TPST2 | tyrosylprotein sulfotransferase 2 | 0.4 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | 0.39 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.39 |
| ATF7 | activating transcription factor 7 | 0.39 |
| CCNDBP1 | cyclin D-type binding-protein 1 | 0.39 |
| APPL2 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 | 0.39 |
| FAM117A | family with sequence similarity 117, member A | 0.38 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | 0.38 |
| MED31 | mediator complex subunit 31 | 0.38 |
| TRAPPC3 | trafficking protein particle complex 3 | 0.38 |
| ANGPTL4 | angiopoietin-like 4 | 0.38 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | 0.38 |
| COQ9 | coenzyme Q9 | 0.38 |
| PGRMC1 | progesterone receptor membrane component 1 | 0.38 |
| HSBP1 | heat shock factor binding protein 1 | 0.37 |
| RILPL2 | Rab interacting lysosomal protein-like 2 | 0.37 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.37 |
| SMIM12 | small integral membrane protein 12 | 0.37 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.37 |
| TCTEX1D2 | Tctex1 domain containing 2 | 0.37 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 0.36 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | 0.36 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RAB36 | RAB36, member RAS oncogene family | -1.11 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -0.68 |
| CNTRL | centriolin | -0.65 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | -0.57 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.56 |
| TBX3 | T-box 3 | -0.56 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.54 |
| SPTB | spectrin, beta, erythrocytic | -0.53 |
| ALPP | alkaline phosphatase, placental | -0.49 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.47 |
| LYST | lysosomal trafficking regulator | -0.47 |
| AGRN | agrin | -0.47 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | -0.46 |
| COL1A1 | collagen, type I, alpha 1 | -0.46 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.43 |
| MROH6 | maestro heat-like repeat family member 6 | -0.42 |
| LRRK1 | leucine-rich repeat kinase 1 | -0.42 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | -0.41 |
| ENOX2 | ecto-NOX disulfide-thiol exchanger 2 | -0.41 |
| C12ORF66 | chromosome 12 open reading frame 66 | -0.4 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | -0.4 |
| NABP2 | nucleic acid binding protein 2 | -0.39 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.39 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.39 |
| ARSB | arylsulfatase B | -0.38 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.37 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.37 |
| ZNF696 | zinc finger protein 696 | -0.37 |
| PRDM11 | PR domain containing 11 | -0.37 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | -0.37 |
| BBS4 | Bardet-Biedl syndrome 4 | -0.36 |
| NFKBIL1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | -0.35 |
| EPDR1 | ependymin related 1 | -0.35 |
| PACC1 | proton activated chloride channel 1 | -0.35 |
| FGF2 | fibroblast growth factor 2 (basic) | -0.35 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.34 |
| FGGY | FGGY carbohydrate kinase domain containing | -0.34 |
| WRAP73 | WD repeat containing, antisense to TP73 | -0.34 |
| ODF2L | outer dense fiber of sperm tails 2-like | -0.34 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.34 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | -0.34 |
| WDR25 | WD repeat domain 25 | -0.34 |
| MTFMT | mitochondrial methionyl-tRNA formyltransferase | -0.33 |
| ZC4H2 | zinc finger, C4H2 domain containing | -0.33 |
| RAD51B | RAD51 paralog B | -0.33 |
| RPP14 | ribonuclease P/MRP 14kDa subunit | -0.33 |
| PLXNB1 | plexin B1 | -0.32 |
| NBR1 | neighbor of BRCA1 gene 1 | -0.32 |
| FHL2 | four and a half LIM domains 2 | -0.32 |
| ATG4D | autophagy related 4D, cysteine peptidase | -0.31 |
| KDM4D | lysine (K)-specific demethylase 4D | -0.31 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.31 |
| DSTN | destrin (actin depolymerizing factor) | -0.3 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -0.3 |
| GPR161 | G protein-coupled receptor 161 | -0.3 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.3 |
| FAM221A | family with sequence similarity 221, member A | -0.3 |
| RNF13 | ring finger protein 13 | -0.3 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | -0.3 |
| TBCK | TBC1 domain containing kinase | -0.3 |
| DUSP4 | dual specificity phosphatase 4 | -0.3 |
| TSC22D2 | TSC22 domain family, member 2 | -0.29 |
| APOB | apolipoprotein B | -0.29 |
| ZNF791 | zinc finger protein 791 | -0.29 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.29 |
| B4GALT7 | xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 | -0.29 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -0.28 |
| RHOD | ras homolog family member D | -0.28 |
| IRX4 | iroquois homeobox 4 | -0.28 |
| CKM | creatine kinase, muscle | -0.28 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.28 |
| TMCO4 | transmembrane and coiled-coil domains 4 | -0.28 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.28 |
| TPCN1 | two pore segment channel 1 | -0.28 |
| ZNF114 | zinc finger protein 114 | -0.27 |
| ATPSCKMT | ATP synthase c subunit lysine N-methyltransferase | -0.27 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.27 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | -0.27 |
| TRIM23 | tripartite motif containing 23 | -0.27 |
| XDH | xanthine dehydrogenase | -0.27 |
| RHOF | ras homolog family member F (in filopodia) | -0.27 |
| TSLIG1 | tRNA splicing ligase complex subunit 1 | -0.27 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.27 |
| ZXDB | zinc finger, X-linked, duplicated B | -0.27 |
| TMC7 | transmembrane channel-like 7 | -0.26 |
| NACC2 | NACC family member 2, BEN and BTB (POZ) domain containing | -0.26 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | -0.26 |
| IL10RB | interleukin 10 receptor, beta | -0.26 |
| PAH | phenylalanine hydroxylase | -0.26 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.26 |
| STK19 | serine/threonine kinase 19 | -0.26 |
| TYSND1 | trypsin domain containing 1 | -0.26 |
| EPHB2 | EPH receptor B2 | -0.25 |
| LDHD | lactate dehydrogenase D | -0.25 |
| PRDM4 | PR domain containing 4 | -0.25 |
| FEM1A | fem-1 homolog a (C. elegans) | -0.25 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.25 |
| DALRD3 | DALR anticodon binding domain containing 3 | -0.25 |
| PGGT1B | protein geranylgeranyltransferase type I, beta subunit | -0.25 |
