Bisoprolol (hemifumarate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.111904
INTS6 integrator complex subunit 6 0.0708218
PTMA prothymosin, alpha 0.057284
EGR1 early growth response 1 0.0563129
PDE4D phosphodiesterase 4D, cAMP-specific 0.0515941
YAP1 Yes-associated protein 1 0.0468202
ASPH aspartate beta-hydroxylase 0.0436821
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0435675
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0428374
EHBP1 EH domain binding protein 1 0.042711
TPT1 tumor protein, translationally-controlled 1 0.0424797
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0392275
TUBA1B tubulin, alpha 1b 0.0385051
SLC38A2 solute carrier family 38, member 2 0.0378766
LRRC23 leucine rich repeat containing 23 0.0371686
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0364438
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0352761
DENND5A DENN/MADD domain containing 5A 0.0343918
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.033654
TM4SF1 transmembrane 4 L six family member 1 0.0324732
HSPH1 heat shock 105kDa/110kDa protein 1 0.0300163
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0292301
MSRB3 methionine sulfoxide reductase B3 0.0281976
CUX1 cut-like homeobox 1 0.0275481
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0273478
HDAC9 histone deacetylase 9 0.0261262
NHSL1 NHS-like 1 0.0247152
TGM2 transglutaminase 2 0.0242818
EDARADD EDAR-associated death domain 0.024256
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0242069
MACF1 microtubule-actin crosslinking factor 1 0.0237776
RAB10 RAB10, member RAS oncogene family 0.0234665
ZFAND3 zinc finger, AN1-type domain 3 0.0233692
VCL vinculin 0.0232321
RCOR1 REST corepressor 1 0.0227644
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0227351
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.022492
IFIH1 interferon induced with helicase C domain 1 0.0223469
RPS24 ribosomal protein S24 0.0222865
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0218455
AGO3 argonaute RISC catalytic component 3 0.0217964
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0215174
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0211001
RPS23 ribosomal protein S23 0.0210161
ATP5F1B ATP synthase F1 subunit beta 0.0209751
R3HDM2 R3H domain containing 2 0.0206899
ADIPOR2 adiponectin receptor 2 0.0206698
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0206323
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0202723
TIMP2 TIMP metallopeptidase inhibitor 2 0.0201992
ASXL1 additional sex combs like transcriptional regulator 1 0.0200739
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0198918
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.019853
C1S complement component 1, s subcomponent 0.0198413
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0198403
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0197386
ACTG1 actin gamma 1 0.0197235
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0195142
FGFR1 fibroblast growth factor receptor 1 0.0194832
GSK3B glycogen synthase kinase 3 beta 0.0194259
UBAP2 ubiquitin associated protein 2 0.0187667
RCC1 regulator of chromosome condensation 1 0.0187263
TRAF3 TNF receptor-associated factor 3 0.0185769
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0185137
RPS13 ribosomal protein S13 0.0184942
DNAH14 dynein, axonemal, heavy chain 14 0.0183888
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0183878
BCHE butyrylcholinesterase 0.018214
GCG glucagon 0.0180948
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0178551
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 0.0177281
TAS2R14 taste receptor, type 2, member 14 0.0176022
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.0174649
ZSWIM6 zinc finger, SWIM-type containing 6 0.0173704
NUP98 nucleoporin 98kDa 0.0171114
CFAP70 cilia and flagella associated protein 70 0.0170408
S100A10 S100 calcium binding protein A10 0.0168239
SCLT1 sodium channel and clathrin linker 1 0.0167476
KDM4C lysine (K)-specific demethylase 4C 0.0166751
DUSP16 dual specificity phosphatase 16 0.0166092
TNRC18 trinucleotide repeat containing 18 0.0165397
AHRR aryl-hydrocarbon receptor repressor 0.0164347
ATF7 activating transcription factor 7 0.0162798
CELF2 CUGBP, Elav-like family member 2 0.016234
VMP1 vacuole membrane protein 1 0.0161908
HLA-B major histocompatibility complex, class I, B 0.0161468
RERE arginine-glutamic acid dipeptide (RE) repeats 0.015958
TBCA tubulin folding cofactor A 0.015841
TTC17 tetratricopeptide repeat domain 17 0.0153766
ADGRG6 adhesion G protein-coupled receptor G6 0.0153219
PDIA6 protein disulfide isomerase family A, member 6 0.0151517
RPS27A ribosomal protein S27a 0.0151055
PDCD6 programmed cell death 6 0.0150952
INTS4 integrator complex subunit 4 0.0150431
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0150008
TEX14 testis expressed 14 0.0149149
LPP LIM domain containing preferred translocation partner in lipoma 0.0148662
RPL15 ribosomal protein L15 0.0147969
C5AR1 complement component 5a receptor 1 0.0146752
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0146189

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.264114
TMSB10 thymosin beta 10 -0.254828
AREG amphiregulin -0.140558
YBX3 Y box binding protein 3 -0.121885
FTL ferritin, light polypeptide -0.100501
ANKRD12 ankyrin repeat domain 12 -0.0735592
RPS19 ribosomal protein S19 -0.073232
CNRIP1 cannabinoid receptor interacting protein 1 -0.0731574
MYL12B myosin, light chain 12B, regulatory -0.07057
RPLP1 ribosomal protein, large, P1 -0.0639227
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.059334
RPL23 ribosomal protein L23 -0.0581876
RPL12 ribosomal protein L12 -0.0580923
ANXA1 annexin A1 -0.0566386
EDN1 endothelin 1 -0.0554839
GARS1 glycyl-tRNA synthetase 1 -0.0553762
RPL36 ribosomal protein L36 -0.0534704
RPL26 ribosomal protein L26 -0.0527414
TMEM41B transmembrane protein 41B -0.0526341
RPL19 ribosomal protein L19 -0.0499375
TPI1 triosephosphate isomerase 1 -0.0487445
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0486076
XPO1 exportin 1 -0.0448402
RPS4X ribosomal protein S4, X-linked -0.04459
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0430531
EIF1 eukaryotic translation initiation factor 1 -0.0428629
DST dystonin -0.0425637
RPL32 ribosomal protein L32 -0.0422033
PFN1 profilin 1 -0.0421299
CCDC88A coiled-coil domain containing 88A -0.0418168
RPL18 ribosomal protein L18 -0.0411095
SLC38A1 solute carrier family 38, member 1 -0.0398622
YBX1 Y box binding protein 1 -0.0395276
DPYD dihydropyrimidine dehydrogenase -0.0393007
KIF5B kinesin family member 5B -0.039106
RPL11 ribosomal protein L11 -0.0382482
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0376201
BIRC3 baculoviral IAP repeat containing 3 -0.037342
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0370786
PRRC2C proline-rich coiled-coil 2C -0.0352209
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0350141
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0348007
SON SON DNA binding protein -0.0346291
RPL34 ribosomal protein L34 -0.034549
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0343169
MAP1B microtubule-associated protein 1B -0.0336786
NAP1L1 nucleosome assembly protein 1-like 1 -0.0331576
SEC62 SEC62 homolog (S. cerevisiae) -0.0330135
RPS3 ribosomal protein S3 -0.0329361
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0328872
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0321853
NACA nascent polypeptide-associated complex alpha subunit -0.0321316
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0321176
RPL5 ribosomal protein L5 -0.0320122
EEF1G eukaryotic translation elongation factor 1 gamma -0.0319204
RPS12 ribosomal protein S12 -0.0318478
RACK1 receptor for activated C kinase 1 -0.0316479
GNAS GNAS complex locus -0.0316443
RPS21 ribosomal protein S21 -0.0311103
RPS27 ribosomal protein S27 -0.0307709
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0305547
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0305339
SMC4 structural maintenance of chromosomes 4 -0.0300358
RBM25 RNA binding motif protein 25 -0.0296465
RPS6 ribosomal protein S6 -0.0292712
TXNRD1 thioredoxin reductase 1 -0.0289809
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0289666
PTMS parathymosin -0.0280008
KIF18B kinesin family member 18B -0.0278376
MKI67 marker of proliferation Ki-67 -0.0278158
RPS8 ribosomal protein S8 -0.027714
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0276921
RPL7 ribosomal protein L7 -0.027648
NCOR1 nuclear receptor corepressor 1 -0.0275972
ATP5F1E ATP synthase F1 subunit epsilon -0.0272605
HMGA1 high mobility group AT-hook 1 -0.0271675
RPL37 ribosomal protein L37 -0.0271119
RPLP0 ribosomal protein, large, P0 -0.026902
U2SURP U2 snRNP-associated SURP domain containing -0.0264969
MATR3 matrin 3 -0.0264437
MRPL51 mitochondrial ribosomal protein L51 -0.0263268
CBX3 chromobox homolog 3 -0.0259839
KLF6 Kruppel-like factor 6 -0.025966
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0254863
PCM1 pericentriolar material 1 -0.0253469
ZFR zinc finger RNA binding protein -0.0252233
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0251825
RAB1A RAB1A, member RAS oncogene family -0.0249321
ZNF292 zinc finger protein 292 -0.0247948
RPS26 ribosomal protein S26 -0.0247081
LOC112694756 uncharaterized LOC112694756 -0.0241477
REPS1 RALBP1 associated Eps domain containing 1 -0.0241292
RPL27 ribosomal protein L27 -0.0240526
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0237894
SRSF11 serine/arginine-rich splicing factor 11 -0.0236356
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0236138
OGA O-GlcNAcase -0.0231859
BCAS3 breast carcinoma amplified sequence 3 -0.0231537
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0231521
GPX4 glutathione peroxidase 4 -0.0231321