Bisoprolol (hemifumarate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) 0.112266
SMAD3 SMAD family member 3 0.0892781
CSF1 colony stimulating factor 1 (macrophage) 0.0814359
NAV2 neuron navigator 2 0.0813767
EXT1 exostosin glycosyltransferase 1 0.0781155
ZFP36L1 ZFP36 ring finger protein-like 1 0.0765303
FTH1 ferritin, heavy polypeptide 1 0.0758691
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0637139
MYH9 myosin, heavy chain 9, non-muscle 0.0631139
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.054913
NRP2 neuropilin 2 0.0541507
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0529061
HLA-B major histocompatibility complex, class I, B 0.0508416
MT2A metallothionein 2A 0.0483425
VCL vinculin 0.0430033
NRIP1 nuclear receptor interacting protein 1 0.0427642
SEPTIN9 septin 9 0.0425713
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0425338
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0412646
PAX8 paired box 8 0.04112
CA12 carbonic anhydrase XII 0.0405986
APOL1 apolipoprotein L, 1 0.039922
TGM2 transglutaminase 2 0.0398889
LOXL2 lysyl oxidase-like 2 0.0385698
IFI6 interferon, alpha-inducible protein 6 0.0361676
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0357921
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.035111
IFI16 interferon, gamma-inducible protein 16 0.0348409
IFI27 interferon, alpha-inducible protein 27 0.0346336
IFI44L interferon-induced protein 44-like 0.0338536
ACTN4 actinin, alpha 4 0.033374
HLA-A major histocompatibility complex, class I, A 0.0323256
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0321933
MYO1E myosin IE 0.0320459
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0318785
MSN moesin 0.0316833
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0316275
CDCP1 CUB domain containing protein 1 0.0315663
LOC112694756 uncharaterized LOC112694756 0.0310908
HDAC9 histone deacetylase 9 0.0305759
TPT1 tumor protein, translationally-controlled 1 0.0301654
MYADM myeloid-associated differentiation marker 0.0301598
ICAM1 intercellular adhesion molecule 1 0.030054
CXCL8 chemokine (C-X-C motif) ligand 8 0.0296014
LENG8 leukocyte receptor cluster (LRC) member 8 0.0289363
RTN4 reticulon 4 0.028262
CCL2 chemokine (C-C motif) ligand 2 0.0276943
TIMP2 TIMP metallopeptidase inhibitor 2 0.0274662
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0274403
CMIP c-Maf inducing protein 0.0268469
OSMR oncostatin M receptor 0.0267613
DOCK5 dedicator of cytokinesis 5 0.0267405
ECE1 endothelin converting enzyme 1 0.0262111
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0260042
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0257777
HLA-C major histocompatibility complex, class I, C 0.025723
B2M beta-2-microglobulin 0.0256546
BHLHE40 basic helix-loop-helix family, member e40 0.0255001
LOC102724023 ES1 protein homolog, mitochondrial 0.0254265
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0248175
FLNA filamin A, alpha 0.0248029
EGR1 early growth response 1 0.0246617
MX1 MX dynamin-like GTPase 1 0.0242227
S100A10 S100 calcium binding protein A10 0.0238598
TUBA1B tubulin, alpha 1b 0.0237561
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0235279
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0230709
LY6E lymphocyte antigen 6 complex, locus E 0.0230332
HM13 histocompatibility (minor) 13 0.023033
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0230244
FOSL2 FOS-like antigen 2 0.0229233
NRP1 neuropilin 1 0.022918
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.0228302
RRM2 ribonucleotide reductase M2 0.02255
CYB5R3 cytochrome b5 reductase 3 0.0225224
SAMD4A sterile alpha motif domain containing 4A 0.0224079
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0223499
P3H2 prolyl 3-hydroxylase 2 0.0222423
VEGFA vascular endothelial growth factor A 0.0221746
TMSB10 thymosin beta 10 0.0220977
CTSD cathepsin D 0.022042
CYBA cytochrome b-245, alpha polypeptide 0.0219623
MKI67 marker of proliferation Ki-67 0.0218431
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0216038
LAMA5 laminin, alpha 5 0.0213109
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0211935
UGCG UDP-glucose ceramide glucosyltransferase 0.0211732
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0211178
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0210319
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0210163
MCL1 myeloid cell leukemia 1 0.0209859
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0209805
TM4SF1 transmembrane 4 L six family member 1 0.0207158
TUBA1C tubulin, alpha 1c 0.0206498
MAML2 mastermind-like 2 (Drosophila) 0.0206154
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0204373
NLGN1 neuroligin 1 0.0204051
WWOX WW domain containing oxidoreductase 0.0203215
AXL AXL receptor tyrosine kinase 0.0202706
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0200014

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.187744
FRMD4A FERM domain containing 4A -0.131088
ZCCHC7 zinc finger, CCHC domain containing 7 -0.116489
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.1136
SOD2 superoxide dismutase 2, mitochondrial -0.106142
TTC3 tetratricopeptide repeat domain 3 -0.0838387
NAMPT nicotinamide phosphoribosyltransferase -0.0790286
PRRC2C proline-rich coiled-coil 2C -0.0737936
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0705494
CANX calnexin -0.0637103
BIRC6 baculoviral IAP repeat containing 6 -0.0617338
ATP13A3 ATPase type 13A3 -0.0594192
PLK2 polo-like kinase 2 -0.0585924
GOLGA4 golgin A4 -0.0580679
IARS1 isoleucyl-tRNA synthetase 1 -0.0580158
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.05689
FTL ferritin, light polypeptide -0.0559746
KMT2C lysine (K)-specific methyltransferase 2C -0.0557514
ZFAND3 zinc finger, AN1-type domain 3 -0.0546434
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0541637
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0539733
GPC6 glypican 6 -0.0537528
SPAG9 sperm associated antigen 9 -0.0509753
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0506
CLTC clathrin, heavy chain (Hc) -0.0496764
GARS1 glycyl-tRNA synthetase 1 -0.049403
SCFD2 sec1 family domain containing 2 -0.0493763
SBF2 SET binding factor 2 -0.0492744
CLINT1 clathrin interactor 1 -0.0486399
MTDH metadherin -0.0480724
COG5 component of oligomeric golgi complex 5 -0.0479693
EHBP1 EH domain binding protein 1 -0.0479484
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0470041
SDCBP syndecan binding protein (syntenin) -0.0469445
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0469128
CDK13 cyclin-dependent kinase 13 -0.0466755
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0455114
PTBP3 polypyrimidine tract binding protein 3 -0.0454999
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0453394
SRPK2 SRSF protein kinase 2 -0.0451828
PTMA prothymosin, alpha -0.0442172
COPB1 coatomer protein complex, subunit beta 1 -0.0434081
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0426554
SPDYA speedy/RINGO cell cycle regulator family member A -0.0422203
HELZ helicase with zinc finger -0.0421833
LMAN1 lectin, mannose-binding, 1 -0.0421295
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0417275
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0412088
QKI QKI, KH domain containing, RNA binding -0.0401041
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0400934
NAP1L1 nucleosome assembly protein 1-like 1 -0.0398667
SEC31A SEC31 homolog A (S. cerevisiae) -0.0398359
MON2 MON2 homolog (S. cerevisiae) -0.0396945
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0392448
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0390229
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0386152
ANKRD10 ankyrin repeat domain 10 -0.0385931
EIF1 eukaryotic translation initiation factor 1 -0.0383875
COPA coatomer protein complex, subunit alpha -0.0383825
RAB1A RAB1A, member RAS oncogene family -0.0380201
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0376486
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0364383
MARCHF6 membrane associated ring-CH-type finger 6 -0.0363547
RAB2A RAB2A, member RAS oncogene family -0.0361411
TRIO trio Rho guanine nucleotide exchange factor -0.0358995
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0354592
GDF15 growth differentiation factor 15 -0.0353687
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0351993
VCAM1 vascular cell adhesion molecule 1 -0.0351304
NAP1L4 nucleosome assembly protein 1-like 4 -0.0349469
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0348555
RHEB Ras homolog enriched in brain -0.0347762
FN1 fibronectin 1 -0.0347411
KDM4C lysine (K)-specific demethylase 4C -0.0343405
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0341691
DST dystonin -0.0341504
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0338732
TARS1 threonyl-tRNA synthetase 1 -0.0337277
PTK2 protein tyrosine kinase 2 -0.0337001
SUCO SUN domain containing ossification factor -0.0336965
DLG1 discs, large homolog 1 (Drosophila) -0.0335235
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0335049
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0332327
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0332185
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0331442
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0329388
LPP LIM domain containing preferred translocation partner in lipoma -0.0329254
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0328024
AKAP9 A kinase (PRKA) anchor protein 9 -0.0327126
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0326502
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.032604
CEP350 centrosomal protein 350kDa -0.0325548
FNBP1L formin binding protein 1-like -0.0325361
LITAF lipopolysaccharide-induced TNF factor -0.0325202
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0322477
HDLBP high density lipoprotein binding protein -0.0322382
TAOK1 TAO kinase 1 -0.03221
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0321023
BRWD1 bromodomain and WD repeat domain containing 1 -0.0319609
KTN1 kinectin 1 (kinesin receptor) -0.0318659