| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bisoprolol (hemifumarate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bisoprolol (hemifumarate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.277305 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.178016 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.135917 |
| EFNA5 | ephrin-A5 | 0.0868783 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0840218 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0823931 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0798996 |
| CA12 | carbonic anhydrase XII | 0.0764734 |
| VIM | vimentin | 0.0739337 |
| EGFR | epidermal growth factor receptor | 0.0726589 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0679587 |
| NDRG1 | N-myc downstream regulated 1 | 0.0659568 |
| MCL1 | myeloid cell leukemia 1 | 0.0630424 |
| PDE10A | phosphodiesterase 10A | 0.0618853 |
| FLNB | filamin B, beta | 0.0570721 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0560433 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.0557909 |
| AUTS2 | autism susceptibility candidate 2 | 0.0543665 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0520709 |
| MYO1E | myosin IE | 0.0492075 |
| EHBP1 | EH domain binding protein 1 | 0.0479942 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.046632 |
| PKM | pyruvate kinase, muscle | 0.0458022 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0456675 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0447449 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0447117 |
| RNF213 | ring finger protein 213 | 0.0441063 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0439267 |
| PRKCA | protein kinase C, alpha | 0.0436179 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0435148 |
| ASPH | aspartate beta-hydroxylase | 0.0421162 |
| STC1 | stanniocalcin 1 | 0.0417893 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0378851 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.037461 |
| ANXA4 | annexin A4 | 0.037384 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0361591 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0361204 |
| RIN2 | Ras and Rab interactor 2 | 0.0358458 |
| PARD3 | par-3 family cell polarity regulator | 0.0349212 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0348252 |
| AXL | AXL receptor tyrosine kinase | 0.0347756 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0342581 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.0341479 |
| NRG1 | neuregulin 1 | 0.0340947 |
| AHNAK | AHNAK nucleoprotein | 0.0340284 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0337755 |
| ZFHX3 | zinc finger homeobox 3 | 0.0331072 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0323496 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0322059 |
| KRT81 | keratin 81, type II | 0.0318673 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0316906 |
| TPM1 | tropomyosin 1 (alpha) | 0.0305874 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0295123 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0293616 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0292028 |
| MAP1B | microtubule-associated protein 1B | 0.0291731 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0290367 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0286071 |
| POTEF | POTE ankyrin domain family, member F | 0.0284892 |
| TGM2 | transglutaminase 2 | 0.0284629 |
| TMSB10 | thymosin beta 10 | 0.0282682 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0282315 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0280195 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0277435 |
| MYADM | myeloid-associated differentiation marker | 0.0276073 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0273223 |
| RAD51B | RAD51 paralog B | 0.0272224 |
| TPM4 | tropomyosin 4 | 0.0268214 |
| TNS1 | tensin 1 | 0.0266071 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0265118 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0264175 |
| CUX1 | cut-like homeobox 1 | 0.0257849 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0257843 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0257834 |
| LOXL2 | lysyl oxidase-like 2 | 0.0257807 |
| PYGL | phosphorylase, glycogen, liver | 0.0253626 |
| LAMA5 | laminin, alpha 5 | 0.0251759 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0250235 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0250091 |
| HIP1 | huntingtin interacting protein 1 | 0.0249558 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0246379 |
| LDHA | lactate dehydrogenase A | 0.0243291 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0242947 |
| TNS3 | tensin 3 | 0.0242477 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0240573 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0239825 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0234823 |
| VCL | vinculin | 0.0234345 |
| CCDC88A | coiled-coil domain containing 88A | 0.0234075 |
| DAPK1 | death-associated protein kinase 1 | 0.0233044 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0231993 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.02314 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | 0.023096 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0230697 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0227247 |
| MYO10 | myosin X | 0.0226529 |
| RAI14 | retinoic acid induced 14 | 0.0221269 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0220202 |
| MSN | moesin | 0.0218437 |
| S100A6 | S100 calcium binding protein A6 | 0.0215258 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.0719291 |
| FTL | ferritin, light polypeptide | -0.0617395 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0286881 |
| RPL26 | ribosomal protein L26 | -0.026349 |
| RPS19 | ribosomal protein S19 | -0.0254329 |
| RPLP1 | ribosomal protein, large, P1 | -0.0248906 |
| GOLGA4 | golgin A4 | -0.0238322 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.022643 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0220842 |
| RPL13A | ribosomal protein L13a | -0.021919 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0212619 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0197152 |
| RPL12 | ribosomal protein L12 | -0.0192756 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0181645 |
| RPL23 | ribosomal protein L23 | -0.0179615 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0177742 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.017261 |
| WDR43 | WD repeat domain 43 | -0.0170148 |
| SPAG9 | sperm associated antigen 9 | -0.0167937 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0160525 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0160369 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0159926 |
| RPS3 | ribosomal protein S3 | -0.0159436 |
| RPL37A | ribosomal protein L37a | -0.0158484 |
| COG5 | component of oligomeric golgi complex 5 | -0.0157826 |
| RPS8 | ribosomal protein S8 | -0.0155691 |
| OGA | O-GlcNAcase | -0.0152981 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0152545 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0149393 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.014835 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0147794 |
| MORF4L2 | mortality factor 4 like 2 | -0.0139166 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0137849 |
| TCERG1 | transcription elongation regulator 1 | -0.0137212 |
| YBX3 | Y box binding protein 3 | -0.0137126 |
| CEP95 | centrosomal protein 95kDa | -0.0136958 |
| PTMA | prothymosin, alpha | -0.0135923 |
| LDHB | lactate dehydrogenase B | -0.0135283 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0134771 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0131225 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0128025 |
| CA8 | carbonic anhydrase VIII | -0.0127378 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.012658 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0126063 |
| RPL9 | ribosomal protein L9 | -0.0125825 |
| RPS4X | ribosomal protein S4, X-linked | -0.0125694 |
| NOP58 | NOP58 ribonucleoprotein | -0.0125356 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0124952 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0122645 |
| WDR45B | WD repeat domain 45B | -0.011953 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0119029 |
| RACK1 | receptor for activated C kinase 1 | -0.0118081 |
| OLA1 | Obg-like ATPase 1 | -0.0117963 |
| RBM39 | RNA binding motif protein 39 | -0.0117407 |
| RPL19 | ribosomal protein L19 | -0.0115658 |
| WRN | Werner syndrome, RecQ helicase-like | -0.0115391 |
| DNAJC25 | DnaJ (Hsp40) homolog, subfamily C , member 25 | -0.0115202 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0115005 |
| USP15 | ubiquitin specific peptidase 15 | -0.0114965 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | -0.011409 |
| NUP58 | nucleoporin 58 | -0.0113959 |
| CLINT1 | clathrin interactor 1 | -0.0113945 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.0113568 |
| RPS6 | ribosomal protein S6 | -0.0113211 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0112845 |
| MIS18BP1 | MIS18 binding protein 1 | -0.011191 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0111192 |
| MATR3 | matrin 3 | -0.0111 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0110314 |
| ANLN | anillin, actin binding protein | -0.0108662 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0107158 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0106181 |
| RPL7 | ribosomal protein L7 | -0.0105769 |
| HELZ | helicase with zinc finger | -0.0105222 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.0105133 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.01051 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0105092 |
| CABIN1 | calcineurin binding protein 1 | -0.0104145 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0103606 |
| RPL30 | ribosomal protein L30 | -0.0102456 |
| USP3 | ubiquitin specific peptidase 3 | -0.0102138 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0101348 |
| TPR | translocated promoter region, nuclear basket protein | -0.0100857 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0100485 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0099623 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.00990848 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.00989278 |
| YBX1 | Y box binding protein 1 | -0.00984469 |
| RBM25 | RNA binding motif protein 25 | -0.00980252 |
| SEC23IP | SEC23 interacting protein | -0.0096319 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.00962706 |
| SUCO | SUN domain containing ossification factor | -0.00954861 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.00953701 |
| RPL11 | ribosomal protein L11 | -0.00949128 |
| IFRD1 | interferon-related developmental regulator 1 | -0.00946104 |
| PUM2 | pumilio RNA-binding family member 2 | -0.00935953 |
| RPL18 | ribosomal protein L18 | -0.00932249 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | -0.00928406 |
| RARS1 | arginyl-tRNA synthetase 1 | -0.0092719 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.00919222 |
