Bisoprolol (hemifumarate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.110481
ERBB2 erb-b2 receptor tyrosine kinase 2 0.110277
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0849486
IGFBP5 insulin-like growth factor binding protein 5 0.0698205
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.0666024
NTN4 netrin 4 0.0632091
ACSL3 acyl-CoA synthetase long-chain family member 3 0.057628
ELOVL5 ELOVL fatty acid elongase 5 0.0575655
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0539676
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0535747
CCND1 cyclin D1 0.0524106
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0500561
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0464703
THSD4 thrombospondin, type I, domain containing 4 0.0430084
ACACA acetyl-CoA carboxylase alpha 0.042904
OSMR oncostatin M receptor 0.0417387
SRCIN1 SRC kinase signaling inhibitor 1 0.0416187
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0411788
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0377902
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 0.0371952
TRPS1 trichorhinophalangeal syndrome I 0.0362452
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0357154
DUSP16 dual specificity phosphatase 16 0.0351367
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0350627
PAWR PRKC, apoptosis, WT1, regulator 0.0349862
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0347664
TOM1L1 target of myb1 (chicken)-like 1 0.034427
AHR aryl hydrocarbon receptor 0.0340892
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0338537
KAZN kazrin, periplakin interacting protein 0.033643
MYO1B myosin IB 0.0333949
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0328448
TMC5 transmembrane channel-like 5 0.0327018
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0325034
DOCK5 dedicator of cytokinesis 5 0.0323683
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0314641
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0310361
TP53INP2 tumor protein p53 inducible nuclear protein 2 0.0309769
CEMIP2 cell migration inducing hyaluronidase 2 0.0307693
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0307452
DUSP4 dual specificity phosphatase 4 0.030331
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0302866
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0300848
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0297462
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.029494
APP amyloid beta (A4) precursor protein 0.0293548
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0291385
GSE1 Gse1 coiled-coil protein 0.0291383
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 0.0278996
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.0275527
VAV3 vav 3 guanine nucleotide exchange factor 0.0274908
LDLR low density lipoprotein receptor 0.0269174
USP53 ubiquitin specific peptidase 53 0.0268961
KLF6 Kruppel-like factor 6 0.0268709
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0268528
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0267984
NCOA7 nuclear receptor coactivator 7 0.0267182
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 0.0265674
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0262555
NCAM2 neural cell adhesion molecule 2 0.026193
WWOX WW domain containing oxidoreductase 0.0257185
ICAM1 intercellular adhesion molecule 1 0.0253054
TC2N tandem C2 domains, nuclear 0.0252125
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0251541
ALCAM activated leukocyte cell adhesion molecule 0.0250351
NF1 neurofibromin 1 0.0246108
GSK3B glycogen synthase kinase 3 beta 0.0242235
GLCCI1 glucocorticoid induced 1 0.024064
ELL2 elongation factor, RNA polymerase II, 2 0.0239593
HSPA8 heat shock 70kDa protein 8 0.023898
ITGB6 integrin, beta 6 0.0238668
FOXP1 forkhead box P1 0.0237874
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0234731
NFIB nuclear factor I/B 0.0232912
EGR1 early growth response 1 0.0231993
TSC22D2 TSC22 domain family, member 2 0.0230083
FADS2 fatty acid desaturase 2 0.0227817
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0226944
S100A9 S100 calcium binding protein A9 0.0225296
ANKRD36C ankyrin repeat domain 36C 0.0224283
BCAS1 breast carcinoma amplified sequence 1 0.0223997
CATSPERB catsper channel auxiliary subunit beta 0.0223501
INSR insulin receptor 0.022019
UBE2H ubiquitin-conjugating enzyme E2H 0.0217866
STS steroid sulfatase (microsomal), isozyme S 0.021648
ENAH enabled homolog (Drosophila) 0.0215787
ANKRD30A ankyrin repeat domain 30A 0.0213659
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.021344
POTEF POTE ankyrin domain family, member F 0.0212907
MED13L mediator complex subunit 13-like 0.0210749
NRIP1 nuclear receptor interacting protein 1 0.0208308
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0207896
ABHD17C abhydrolase domain containing 17C 0.020689
SDC4 syndecan 4 0.0206816
ADAM9 ADAM metallopeptidase domain 9 0.0206158
ZNF652 zinc finger protein 652 0.0203433
CD164 CD164 molecule, sialomucin 0.0202638
NAMPT nicotinamide phosphoribosyltransferase 0.0199161
CCNI cyclin I 0.019856
TMEM45B transmembrane protein 45B 0.0196514

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.228815
FTH1 ferritin, heavy polypeptide 1 -0.145803
NDRG1 N-myc downstream regulated 1 -0.11948
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.108345
RPL19 ribosomal protein L19 -0.108071
INTS6 integrator complex subunit 6 -0.0978149
CEP250 centrosomal protein 250kDa -0.0772544
FBXL20 F-box and leucine-rich repeat protein 20 -0.0763294
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0757185
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0650406
MT2A metallothionein 2A -0.0649438
DTNA dystrobrevin, alpha -0.0616805
RPL37A ribosomal protein L37a -0.0573431
GRB10 growth factor receptor-bound protein 10 -0.0535267
ACTG1 actin gamma 1 -0.0526959
MMP24OS MMP24 opposite strand -0.0523722
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.051776
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0516309
ZMYND8 zinc finger, MYND-type containing 8 -0.0511781
NCOA3 nuclear receptor coactivator 3 -0.0509293
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0500991
PRELID2 PRELI domain containing 2 -0.0482036
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0470265
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0439199
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0434455
STXBP4 syntaxin binding protein 4 -0.0427168
AEBP2 AE binding protein 2 -0.0419742
PLSCR2 phospholipid scramblase 2 -0.0418067
SBF2 SET binding factor 2 -0.0412493
RAB7A RAB7A, member RAS oncogene family -0.0410121
USO1 USO1 vesicle transport factor -0.0408455
TMSB10 thymosin beta 10 -0.0406175
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0395388
ANKRD12 ankyrin repeat domain 12 -0.0392924
GMDS GDP-mannose 4,6-dehydratase -0.0389399
LOC112694756 uncharaterized LOC112694756 -0.0387249
MIPOL1 mirror-image polydactyly 1 -0.038269
KRT86 keratin 86, type II -0.038096
RAD51B RAD51 paralog B -0.036866
KDM5B lysine (K)-specific demethylase 5B -0.0356092
HELZ helicase with zinc finger -0.0349872
RCOR1 REST corepressor 1 -0.033525
FAM219A family with sequence similarity 219, member A -0.0334091
ZNF292 zinc finger protein 292 -0.0330747
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.032356
NABP1 nucleic acid binding protein 1 -0.0323379
DENND1A DENN/MADD domain containing 1A -0.0322249
ZBTB20 zinc finger and BTB domain containing 20 -0.0321322
UBAP2 ubiquitin associated protein 2 -0.0306933
TPD52 tumor protein D52 -0.0305188
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0295911
LIMCH1 LIM and calponin homology domains 1 -0.0293937
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.029332
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0288286
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.0288276
FXR1 fragile X mental retardation, autosomal homolog 1 -0.02875
FAM168A family with sequence similarity 168, member A -0.0287424
ADIPOR2 adiponectin receptor 2 -0.0280292
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0276552
VEGFA vascular endothelial growth factor A -0.0272931
RPL37 ribosomal protein L37 -0.0270898
RPS3 ribosomal protein S3 -0.0270415
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -0.026555
EGFR epidermal growth factor receptor -0.026522
DSCAM Down syndrome cell adhesion molecule -0.0263144
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0262312
RPS19 ribosomal protein S19 -0.0262257
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0261019
RTN3 reticulon 3 -0.0257217
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0256991
GPATCH2L G patch domain containing 2-like -0.025656
ZNF207 zinc finger protein 207 -0.0255308
LARP4B La ribonucleoprotein domain family, member 4B -0.0254175
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0252665
LMNA lamin A/C -0.0250674
SRRM2 serine/arginine repetitive matrix 2 -0.02503
BACE2 beta-site APP-cleaving enzyme 2 -0.0249973
CCNY cyclin Y -0.0249686
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0241864
PGK1 phosphoglycerate kinase 1 -0.0241638
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0241092
FOXN3 forkhead box N3 -0.0240216
BBX bobby sox homolog (Drosophila) -0.0239506
KMT2E lysine (K)-specific methyltransferase 2E -0.0235544
RPS8 ribosomal protein S8 -0.0234398
RYK receptor-like tyrosine kinase -0.0232872
GOLGB1 golgin B1 -0.0232841
MCU mitochondrial calcium uniporter -0.0229516
RBM25 RNA binding motif protein 25 -0.0229021
RC3H1 ring finger and CCCH-type domains 1 -0.0227822
IGF1R insulin-like growth factor 1 receptor -0.0225577
SETD5 SET domain containing 5 -0.0225377
CDK13 cyclin-dependent kinase 13 -0.0223952
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0223527
RPL9 ribosomal protein L9 -0.0221627
SMC4 structural maintenance of chromosomes 4 -0.022154
ENO1 enolase 1, (alpha) -0.0220192
FNIP1 folliculin interacting protein 1 -0.0219296
PARD3 par-3 family cell polarity regulator -0.0217762
SLC22A23 solute carrier family 22, member 23 -0.0217237